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BIIB129

BIIB129 structure

CAS No.: 2770960-52-4

Chemical Name:: BIIB129

Synonyms: BIIB129;N-Methyl-N-(cis-3-methyl-3-((6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)oxy)cyclobutyl)acrylamide;2-Propenamide, N-methyl-N-[cis-3-methyl-3-[[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy]cyclobutyl]-

CBNumber:: CB614222298

Molecular Formula:: C19H22N6O2

Molecular Weight:: 366.42

MDL Number:

MOL File:: 2770960-52-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:57:00

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BIIB129 Properties

Density	1.325±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka	0.774±0.10(predicted)
form	Solid
color	White to off-white

BIIB129 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	43712	BIIB129 ≥98%	2770960-52-4	5mg	$91	2026-04-30	Buy
Cayman Chemical	43712	BIIB129 ≥98%	2770960-52-4	10mg	$172	2026-04-30	Buy
Cayman Chemical	43712	BIIB129 ≥98%	2770960-52-4	25mg	$406	2026-04-30	Buy
Cayman Chemical	43712	BIIB129 ≥98%	2770960-52-4	50mg	$632	2026-04-30	Buy
ChemScene	CS-1053700	BIIB129 99.54%	2770960-52-4	5mg	$206	2026-06-04	Buy

Product number	Packaging	Price	Buy
43712	5mg	$91	Buy
43712	10mg	$172	Buy
43712	25mg	$406	Buy
43712	50mg	$632	Buy
CS-1053700	5mg	$206	Buy

BIIB129 Chemical Properties, Uses, Production

Uses

BIIB129 is a covalent, selective, small molecule inhibitor of Bruton's tyrosine kinase (BTK) capable of penetrating the blood-brain barrier. BIIB129 inhibits the activity of BTK by covalently binding to Cys481 in BTK, thereby affecting the function of B cells and myeloid cells. BIIB129 can be used in multiple sclerosis (MS) research[1].

References

[1] Himmelbauer M K, et al. Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis[J]. Journal of Medicinal Chemistry, 2024. DOI:10.1021/acs.jmedchem.4c00220

BIIB129 Preparation Products And Raw materials

Raw materials

Preparation Products

BIIB129 Suppliers

Global Suppliers ( 11)

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	4565	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840	psaitong@jm-bio.com	China	27626	58
Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd.	15720605021	zhang_lei@jsnchem.com	China	1881	58
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	59929	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	5985	58
Hubei wei shi reagent group ltd., company	17771898297 13125137661	2853877621@qq.com	China	7992	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58
Wuhan Xinsengyang Biotechnology Co., Ltd	18402740988 18402740988	3879363529@qq.com	China	1000	58

Supplier	Advantage
Nanjing Chemlin Chemical Co., Ltd	64
ShangHai ChuanQian Chemcial Technique Centre	58
Beijing Jin Ming Biotechnology Co., Ltd.	58
Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd.	58
Bide Pharmatech Ltd.	58
Nantong QuanYi Biotechnology Co., Ltd	58
Hubei wei shi reagent group ltd., company	58
TargetMol Chemicals Inc.	58
Wuhan Xinsengyang Biotechnology Co., Ltd	58

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BIIB129 N-Methyl-N-(cis-3-methyl-3-((6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)oxy)cyclobutyl)acrylamide 2-Propenamide, N-methyl-N-[cis-3-methyl-3-[[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy]cyclobutyl]- 2770960-52-4