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BIIB129

BIIB129 structure

CAS No.: 2770960-52-4

Chemical Name:: BIIB129

Synonyms: BIIB129;N-Methyl-N-(cis-3-methyl-3-((6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)oxy)cyclobutyl)acrylamide;2-Propenamide, N-methyl-N-[cis-3-methyl-3-[[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy]cyclobutyl]-

CBNumber:: CB614222298

Molecular Formula:: C19H22N6O2

Molecular Weight:: 366.42

MDL Number:

MOL File:: 2770960-52-4.mol

Last updated:2025-04-18 09:51:20

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BIIB129 Properties

Density	1.325±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka	0.774±0.10(predicted)
form	Solid
color	White to off-white

BIIB129 Chemical Properties,Uses,Production

Uses

BIIB129 is a covalent, selective, small molecule inhibitor of Bruton's tyrosine kinase (BTK) capable of penetrating the blood-brain barrier. BIIB129 inhibits the activity of BTK by covalently binding to Cys481 in BTK, thereby affecting the function of B cells and myeloid cells. BIIB129 can be used in multiple sclerosis (MS) research[1].

References

[1] Himmelbauer M K, et al. Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis[J]. Journal of Medicinal Chemistry, 2024. DOI:10.1021/acs.jmedchem.4c00220

BIIB129 Preparation Products And Raw materials

Raw materials

Preparation Products

BIIB129 Suppliers

Global( 11)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	4995	58
Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd.	15720605021	zhang_lei@jsnchem.com	China	1788	58
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	62320	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	5839	58
Beijing Yaoxuan Technology Co.,Ltd.	13141108551	Novochem@163.com	China	50	58
Hubei wei shi reagent group ltd., company	027-59101766 13125137661	2853877621@qq.com	China	8005	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29547	58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd	025-58851090 17714375163	2881759498@qq.com	China	13011	58
Selleck Chemicals	400-668-6834	info@selleck.cn	China	6071	58
Shanghai Weijiahe Biotechnology Co., Ltd	17502176150 17502176150	861873257@qq.com	China	1372	58

Supplier	Advantage
ShangHai ChuanQian Chemcial Technique Centre	58
Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd.	58
Bide Pharmatech Ltd.	58
Nantong QuanYi Biotechnology Co., Ltd	58
Beijing Yaoxuan Technology Co.,Ltd.	58
Hubei wei shi reagent group ltd., company	58
TargetMol Chemicals Inc.	58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd	58
Selleck Chemicals	58
Shanghai Weijiahe Biotechnology Co., Ltd	58

BIIB129 N-Methyl-N-(cis-3-methyl-3-((6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)oxy)cyclobutyl)acrylamide 2-Propenamide, N-methyl-N-[cis-3-methyl-3-[[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy]cyclobutyl]- 2770960-52-4