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NMS-0963

NMS-0963 structure

CAS No.: 2765304-82-1

Chemical Name:: NMS-0963

Synonyms: NMS-0963;1H-Pyrazole-5-carboxamide, N-[(1S)-2-(1-azetidinyl)-1-methylethyl]-3-[2-[(3,5-dimethoxyphenyl)amino]-4-pyrimidinyl]-1-methyl-

CBNumber:: CB614283026

Molecular Formula:: C23H29N7O3

Molecular Weight:: 451.52

MDL Number:

MOL File:: 2765304-82-1.mol

Last updated:2025-04-18 09:51:18

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NMS-0963 Properties

Density	1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka	13.99±0.46(predicted)

NMS-0963 Chemical Properties, Uses, Production

Uses

NMS-0963 (compound 1) is an inhibitor of spleen tyrosine kinase (SYK) with an oral activity and IC50 value of 3 nM. NMS-0963 inhibits BaF3-TEL/SYK cell line proliferative at 27 nM[1].

References

[1] Giovanni Cervi, et al. Discovery and optimization of 4-pyrazolyl-2-aminopyrimidine derivatives as potent spleen tyrosine kinase (SYK) inhibitors. Eur J Med Chem. 2024. DOI:10.1016/j.ejmech.2024.116375

NMS-0963 Preparation Products And Raw materials

Raw materials

Preparation Products

NMS-0963 Suppliers

Global Suppliers ( 1)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

2765304-82-1 (NMS-0963) Related Search:

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NMS-0963 1H-Pyrazole-5-carboxamide, N-[(1S)-2-(1-azetidinyl)-1-methylethyl]-3-[2-[(3,5-dimethoxyphenyl)amino]-4-pyrimidinyl]-1-methyl- 2765304-82-1