Indole-6-carboxylic acid
- CAS No.
- 1670-82-2
- Chemical Name:
- Indole-6-carboxylic acid
- Synonyms
- 1H-INDOLE-6-CARBOXYLIC ACID;6-CARBOXYINDOLE;RARECHEM AL BO 0290;RARECHEM AL BE 1265;TIMTEC-BB SBB000134;6-Carboxy-1H-indole;Indole-6-methyl acid;LABOTEST-BB LT00441293;6-INDOLECARBOXYLIC ACID;Indole-6-carboylic acid
- CBNumber:
- CB9368958
- Molecular Formula:
- C9H7NO2
- Molecular Weight:
- 161.16
- MDL Number:
- MFCD02258929
- MOL File:
- 1670-82-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 249-253 °C(lit.) |
|---|---|
| Boiling point | 287.44°C (rough estimate) |
| Density | 1.2480 (rough estimate) |
| refractive index | 1.5050 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 4.44±0.30(Predicted) |
| form | Powder |
| color | Yellow-beige to orange-brown |
| BRN | 123991 |
| InChI | InChI=1S/C9H7NO2/c11-9(12)7-2-1-6-3-4-10-8(6)5-7/h1-5,10H,(H,11,12) |
| InChIKey | GHTDODSYDCPOCW-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC(C(O)=O)=C2)C=C1 |
| CAS DataBase Reference | 1670-82-2(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-21/22-20/21/22-51-36-22 | |||||||||
| Safety Statements | 22-24/25-37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
Indole-6-carboxylic acid price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 576662 | Indole-6-carboxylic acid 97% | 1670-82-2 | 5g | $155 | 2023-01-07 | Buy |
| TCI Chemical | I0663 | Indole-6-carboxylic Acid >98.0%(HPLC)(T) | 1670-82-2 | 1g | $63 | 2026-04-30 | Buy |
| TCI Chemical | I0663 | Indole-6-carboxylic Acid >98.0%(HPLC)(T) | 1670-82-2 | 5g | $190 | 2026-04-30 | Buy |
| Biosynth | I-2350 | Indole-6-carboxylic acid | 1670-82-2 | 100g | $244 | 2026-06-04 | Buy |
| Biosynth | I-2350 | Indole-6-carboxylic acid | 1670-82-2 | 250g | $500 | 2026-06-04 | Buy |
Indole-6-carboxylic acid Chemical Properties, Uses, Production
Chemical Properties
yellow-beige to orange-brown powder
Uses
• ;Reactant for preparation of D-glutamic acid-based inhibitors of E. coli MurD ligase1• ;Reactant for preparation of indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors2• ;Reactant for preparation of amide conjugates with ketoprofen, as inhibitors of Gli1-mediated transcription in Hedgehog pathway3• ;Reactant for preparation of piperazine-bisamide analogs as human growth hormone secretagogue receptor antagonists for treatment of obesity4• ;Reactant for preparation of pyridinyl carboxylates via esterification with chlorohyd
Uses
- Reactant for preparation of D-glutamic acid-based inhibitors of E. coli MurD ligase
- Reactant for preparation of indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors
- Reactant for preparation of amide conjugates with ketoprofen, as inhibitors of Gli1-mediated transcription in Hedgehog pathway
- Reactant for preparation of piperazine-bisamide analogs as human growth hormone secretagogue receptor antagonists for treatment of obesity
- Reactant for preparation of pyridinyl carboxylates via esterification with chlorohydroxypyridine as SARS-CoV 3CL proinhibitors
- Reactant for preparation of (indolecarbonyl)-D-phenylglycinamide amides as factor Xa inhibitors
Uses
Reactant for preparation of D-glutamic acid-based inhibitors of E. coli MurD ligase Reactant for preparation of indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors Reactant for preparation of amide conju
Synthesis Reference(s)
Journal of Medicinal Chemistry, 35, p. 2419, 1992 DOI: 10.1021/jm00091a010
Synthesis
50820-65-0
1670-82-2
(c) Methyl indole-6-carboxylate (11.0 g) was dissolved in a solvent mixture of tetrahydrofuran (150 ml), methanol (150 ml) and water (63 ml) and lithium hydroxide monohydrate (15.8 g) was added. The reaction mixture was stirred at 60 °C for 6 h. After completion of the reaction, the organic solvent was removed by concentration under reduced pressure. The residue was dissolved in water and acidified with 50% (v/v) hydrochloric acid to pH < 3. The precipitate precipitated was collected by filtration and dried to give indole-6-carboxylic acid (9.6 g, 95% yield) as a tan powder with a melting point of 253°C-254°C. The NMR hydrogen spectroscopic (80 MHz, CDCl3) data were as follows: δ 6.51 (m, 1H, H-3) 8.04 (m, 1H, H-7), 11.43 (br s, 1H, NH), 12.42 (br s, 1H, OH).
References
[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 17, p. 6819 - 6843
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 13, p. 2419 - 2439
[3] Patent: US4898863, 1990, A
[4] Patent: EP242167, 1991, B1
[5] Patent: US2007/60567, 2007, A1. Location in patent: Page/Page column 19
Indole-6-carboxylic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SHANGHAI BANGCHENG CHEMICAL Co.,Ltd. | 021-69106960 13701823997 | 13701823733@163.com | China | 4634 | 60 |
| Wuxi Pengruilai Trading Co.,Ltd | 15370273536 18761559979 | sales@zypharmchem.com | China | 90 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Latest Price from Indole-6-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 1H-Indole-6-carboxylic acid
1670-82-2
|
$1.00-122.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-05-28 | Indole-6-Carboxylic Acid
1670-82-2
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2022-02-25 | Indole-6-carboxylic acid
1670-82-2
|
$10.00 | 1KG | 99% | 500tons/month | Shanxi Naipu Import and Export Co.,Ltd |
-
- 1H-Indole-6-carboxylic acid
1670-82-2
- $1.00-122.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Indole-6-Carboxylic Acid
1670-82-2
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- Indole-6-carboxylic acid
1670-82-2
- $10.00
- 99%
- Shanxi Naipu Import and Export Co.,Ltd
