- Anastrozole Impurity
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- $0.00 / 10mg
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2025-07-31
- CAS:1576-35-8
- Min. Order: 10mg
- Purity: 98
- Supply Ability: 10000000
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| | 4-Methylbenzenesulfonhydrazide Basic information | | Uses |
| | 4-Methylbenzenesulfonhydrazide Chemical Properties |
| Melting point | 103-108 °C(lit.) | | Boiling point | 340.5±35.0 °C(Predicted) | | density | 1.42g/cm3 | | vapor pressure | 0Pa at 20℃ | | refractive index | 1.5400 (estimate) | | Fp | 60°C | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | 5g/l | | form | Powder | | pka | 9.39±0.10(Predicted) | | color | White or off-white to slightly grayish | | Water Solubility | 5 g/L (15 ºC) | | Sensitive | Moisture Sensitive | | BRN | 610130 | | Stability: | Light Sensitive | | InChIKey | ICGLPKIVTVWCFT-UHFFFAOYSA-N | | LogP | 0.55 at 25℃ | | CAS DataBase Reference | 1576-35-8(CAS DataBase Reference) | | EPA Substance Registry System | Benzenesulfonic acid, 4-methyl-, hydrazide (1576-35-8) |
| Hazard Codes | F,Xn | | Risk Statements | 11-22-44-2017/11/22 | | Safety Statements | 16-26 | | RIDADR | UN 3226 4.1 | | WGK Germany | 3 | | RTECS | MW0210000 | | TSCA | Yes | | HazardClass | 4.1 | | PackingGroup | II | | HS Code | 29280090 |
| | 4-Methylbenzenesulfonhydrazide Usage And Synthesis |
| Uses | p-Toluenesulfonyl Hydrazide is a reactant that has been used in the synthesis of paspaline. | | Chemical Properties | white to off-white powder | | Uses | 4-Methylbenzenesulfonhydrazide was widely used reagent for the preparation of tosylhydrazones. | | Application | p-Toluenesulfonyl hydrazide is used as a reagent for the preparation of tosylhydrazones. It was used to prepare dipyrazolo[1,5-a:4',3'-c]pyridines and 1,2,3-selenadiazole derivatives. | | Reactions | 4-Methylbenzenesulfonhydrazide as hydrogen donor in reduction reactions: A base-mediated semihydrogenation of ynamides using 4-Methylbenzenesulfonhydrazide (p-toluenesulfonyl
hydrazide) as an inexpensive and easy-to-handle hydrogen donor provides the
thermodynamically unfavorable Z-enamides exclusively without
overhydrogenation and reduction of other functional groups. | | Flammability and Explosibility | Not classified | | Synthesis | General procedure for the synthesis of p-toluenesulfonyl hydrazide from p-toluenesulfonyl chloride: general method: preparation of p-toluenesulfonyl hydrazide. A mixed solution of water (300 mL) and hydrazine hydrate (12.5 g; 0.25 mol) was cooled to about 5 °C in an ice-water bath. The reaction temperature was kept below 8 °C while a tetrahydrofuran (50 mL) solution of p-toluenesulfonyl chloride (5.54 g, 0.025 mol) was slowly added under stirring. After the addition was completed, the reaction mixture was continued to be stirred at room temperature for 30 min. Subsequently, the tetrahydrofuran was removed by distillation under reduced pressure. The white solid product was isolated by filtration and washed with cold water (3 x 15 mL). Finally, the product was dried in air overnight to give pure p-toluenesulfonyl hydrazide (4.86 g; 89% yield). | | Purification Methods | Dissolve the 4-Methylbenzenesulfonhydrazide in hot MeOH (~1g/4mL), filter through Celite and precipitate the material by adding 2-2.5 volumes of distilled H2O. Dry it in air or in a vacuum. [Fiedman et al. Org Synth Coll Vol V 1055 1973, Beilstein 11 II 66.] | | References | [1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 17, p. 4629 - 4636
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 13, p. 3397 - 3407
[3] Archiv der Pharmazie, 2014, vol. 347, # 8, p. 576 - 588
[4] Patent: CN107056871, 2017, A. Location in patent: Paragraph 0022; 0030; 0038
[5] Journal of Molecular Structure, 2017, vol. 1133, p. 80 - 89 |
| | 4-Methylbenzenesulfonhydrazide Preparation Products And Raw materials |
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