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4-Amino-6-chloro-2-(methylthio)pyrimidine

4-Amino-6-chloro-2-(methylthio)pyrimidine structure

CAS No.: 1005-38-5

Chemical Name:: 4-Amino-6-chloro-2-(methylthio)pyrimidine

Synonyms: U 8342;TIMTEC-BB SBB003786;1-[butoxy(phenyl)methyl]piperidine;6-Chloro-2-methylthio-4-pyrimidinamine;6-chloro-2-methylthiopyrimidin-4-ylamine;6-CHLORO-2-(METHYLTHIO)PYRIMIDIN-4-AMINE;4-AMINO-6-CHLORO-2-(METHYLTHIO)PYRIMIDINE;2-(Methylthio)-6-chloropyrimidine-4-amine;4-Pyrimidinamine, 6-chloro-2-(methylthio)-;6-AMINO-4-CHLORO-2-METHYLMERCAPTOPYRIMIDINE

CBNumber:: CB6171009

Molecular Formula:: C5H6ClN3S

Molecular Weight:: 175.64

MDL Number:: MFCD00006088

MOL File:: 1005-38-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:10

Product description	Number	Pack Size	Price
4-Amino-6-chloro-2-(methylthio)pyrimidine 97%	A46005	5g	$93.4
4-Amino-6-chloro-2-(methylthio)pyrimidine 97%	A46005	25g	$444
4-Amino-6-chloro-2-(methylthio)pyrimidine >98.0%(GC)(T)	A2848	5g	$50
4-Amino-6-chloro-2-(methylthio)pyrimidine >98.0%(GC)(T)	A2848	25g	$356
4-Amino-6-chloro-2-(methylthio)pyrimidine	A617393	100mg	$75
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4-Amino-6-chloro-2-(methylthio)pyrimidine Properties

Melting point	130-132 °C (lit.)
Boiling point	338.7±22.0 °C(Predicted)
Density	1.395 (estimate)
refractive index	1.6100 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
pka	1.11±0.10(Predicted)
form	Crystalline Powder
color	Off-white to beige or yellow
InChI	1S/C5H6ClN3S/c1-10-5-8-3(6)2-4(7)9-5/h2H,1H3,(H2,7,8,9)
InChIKey	ISUXMAHVLFRZQU-UHFFFAOYSA-N
SMILES	CSc1nc(N)cc(Cl)n1
CAS DataBase Reference	1005-38-5(CAS DataBase Reference)
FDA UNII	P8SND49KYK
NIST Chemistry Reference	Pyrimidine, 4-amino-6-chloro-2-(methylthio)-(1005-38-5)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

target organs

Respiratory system

Hazard Codes

Risk Statements

36/37/38

Safety Statements

37/39-26

WGK Germany

HS Code

29335990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

4-Amino-6-chloro-2-(methylthio)pyrimidine price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A46005	4-Amino-6-chloro-2-(methylthio)pyrimidine 97%	1005-38-5	5g	$93.4	2023-01-07	Buy
Sigma-Aldrich	A46005	4-Amino-6-chloro-2-(methylthio)pyrimidine 97%	1005-38-5	25g	$444	2023-01-07	Buy
TCI Chemical	A2848	4-Amino-6-chloro-2-(methylthio)pyrimidine >98.0%(GC)(T)	1005-38-5	5g	$50	2026-04-30	Buy
TCI Chemical	A2848	4-Amino-6-chloro-2-(methylthio)pyrimidine >98.0%(GC)(T)	1005-38-5	25g	$356	2021-12-16	Buy
TRC	A617393	4-Amino-6-chloro-2-(methylthio)pyrimidine	1005-38-5	100mg	$75	2021-12-16	Buy

Product number	Packaging	Price	Buy
A46005	5g	$93.4	Buy
A46005	25g	$444	Buy
A2848	5g	$50	Buy
A2848	25g	$356	Buy
A617393	100mg	$75	Buy

4-Amino-6-chloro-2-(methylthio)pyrimidine Chemical Properties,Uses,Production

Uses

4-Amino-6-chloro-2-(methylthio)pyrimidine is a halogenated heterocycle, a useful synthesis intermediate.

Chemical Properties

off-white to beige or yellow crystalline powder

Uses

4-Amino-6-chloro-2-(methylthio)pyrimidine is a halogenated heterocycle, a useful synthesis intermediate.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 1098, 1955 DOI: 10.1021/ja01610a006

Synthesis

6299-25-8

1005-38-5

General procedure for the synthesis of 4-amino-6-chloro-2-(methylthio)pyrimidine from 4,6-dichloro-2-(methylthio)pyrimidine: 1. 4,6-Dichloro-2-(methylthio)pyrimidine was added slowly in a 2L autoclave with THF and ammonia. 2. The reaction mixture was heated to 50-60°C and kept at that temperature for 3-4 hours (pressure in the reactor was maintained at 7-8 Kg/cm2). 3. The progress of the reaction was monitored by TLC. 4. After completion of the reaction, the reaction mixture was cooled to 25-35°C. 5. 5. Concentrate the reaction mixture under vacuum. 6. 6. Hexane was added and stirred at 25-35 °C for 30-45 min. 7. Collect the solid product by filtration and wash with hexane. 8. Wash the solid product with water (2 x 400 mL). 9. Dry the solid product at 25-35 °C until the moisture content (MC) is less than 2%. Yield: 352.0 g. Yield: 97.77%. HPLC purity: 99.07%. Note: For different analogs, other suitable conditions may be used, such as the use of methanol or dioxane solutions of ammonia. Example 1-2: Preparation of 4-amino-6-chloro-2-methylthiopyrimidine, step 6.1.

References

[1] Patent: WO2011/97594, 2011, A2. Location in patent: Page/Page column 100-101
[2] Chemistry - A European Journal, 1999, vol. 5, # 12, p. 3450 - 3458
[3] Patent: WO2007/141571, 2007, A2. Location in patent: Page/Page column 25
[4] American Chemical Journal, 1904, vol. 32, p. 353
[5] Patent: US2005/288502, 2005, A1. Location in patent: Page/Page column 20

4-Amino-6-chloro-2-(methylthio)pyrimidine Preparation Products And Raw materials

Raw materials

4-AMINO-2-(METHYLTHIO)-6-PYRIMIDINOL 4,6-Dichloro-2-(methylthio)pyrimidine Ammonia Tetrahydrofuran

Preparation Products

4-Amino-6-chloro-2-(methylthio)pyrimidine Suppliers

Global( 191)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29794	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8828	58
Shanghai Rlavie Technology Co ltd	+86-021-67759270 +8617717059219	sales@rlavie.com	China	1030	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
Shenzhen Nexconn Pharmatechs Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Shanghai Rlavie Technology Co ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from 4-Amino-6-chloro-2-(methylthio)pyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	4-Amino-6-chloro-2-(methylthio)pyrimidine 1005-38-5	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2025-09-25	4-Amino-6-chloro-2-(methylthio)pyrimidine 1005-38-5	US $200.00-1.00 / KG	1KG	99%, 99.5% Sublimated	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2022-04-25	4-Amino-6-chloro-2-(methylthio)pyrimidine 1005-38-5	US $0.00-0.00 / KG	0.001KG	98%min	10kgs/month	Shanghai Rlavie Technology Co ltd

4-Amino-6-chloro-2-(methylthio)pyrimidine
1005-38-5
US $1.10 / g
99.00%
Dideu Industries Group Limited

4-Amino-6-chloro-2-(methylthio)pyrimidine
1005-38-5
US $200.00-1.00 / KG
99%, 99.5% Sublimated
Henan Fengda Chemical Co., Ltd

4-Amino-6-chloro-2-(methylthio)pyrimidine
1005-38-5
US $0.00-0.00 / KG
98%min
Shanghai Rlavie Technology Co ltd

4-Amino-6-chloro-2-(methylthio)pyrimidine Spectrum

4-Amino-6-chloro-2-(methylthio)pyrimidine(1005-38-5)MS 4-Amino-6-chloro-2-(methylthio)pyrimidine(1005-38-5)¹HNMR 4-Amino-6-chloro-2-(methylthio)pyrimidine(1005-38-5)¹³CNMR 4-Amino-6-chloro-2-(methylthio)pyrimidine(1005-38-5)IR1 4-Amino-6-chloro-2-(methylthio)pyrimidine(1005-38-5)IR2 4-Amino-6-chloro-2-(methylthio)pyrimidine(1005-38-5)Raman

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4-Pyrimidinamine, 6-chloro-2-(methylthio)- 6-Chloro-2-(methylsulfanyl)-4-pyrimidinylamine U 8342 2-METHYLMERCAPTO-4-AMINO-AMINO-6-CHLOROPYRIMIDINE 4-AMINO-6-CHLORO-2-METHYLMERCAPTOPYRIMIDINE 4-AMINO-6-CHLORO-2-(METHYLTHIO)PYRIMIDINE 6-AMINO-4-CHLORO-2-METHYLMERCAPTOPYRIMIDINE 6-CHLORO-2-(METHYLTHIO)PYRIMIDIN-4-AMINE TIMTEC-BB SBB003786 6-chloro-2-methylthiopyrimidin-4-ylamine 1-[butoxy(phenyl)methyl]piperidine JR-8886, 4-Amino-6-chloro-2(methylthio)pyrimidine, 97% 4-AMINO-6-CHLORO-2-METHYLMERCAPTOPYRIMIDINE 97% 4-Amino-6-chloro-2-(methylthio)pyrimidine ,98% 4-Amino-6-chloro-2-methylmercaptopyrimidine ,98% 2-(Methylthio)-6-chloropyrimidine-4-amine 6-Chloro-2-methylthio-4-pyrimidinamine 4-Amino-6-chloro-2-methylmercaptopyrimidine,97% 6-chloro-2-methylsulfanylpyrimidin-4-yl amine 4-Amino-6-chloro-2-(methylthio)pyrimidine> 4-Amino-6-chloro-2-(methylthio)pyrimidine ISO 9001：2015 REACH 1005-38-5 C5H6ClN3S Heterocyclic Building Blocks Halogenated Heterocycles Pyrimidines HETERO CHLORIDE Building Blocks Building Blocks C4 to C5 Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyrimidines PyrimidinesHeterocyclic Building Blocks Heterocycle-Pyrimidine series Sulphur Derivatives