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4-Amino-6-chloro-2-(methylthio)pyrimidine

4-Amino-6-chloro-2-(methylthio)pyrimidine Structure
4-Amino-6-chloro-2-(methylthio)pyrimidine structure
CAS No.
1005-38-5
Chemical Name:
4-Amino-6-chloro-2-(methylthio)pyrimidine
Synonyms
6-CHLORO-2-(METHYLTHIO)PYRIMIDIN-4-AMINE;U 8342;TIMTEC-BB SBB003786;1-[butoxy(phenyl)methyl]piperidine;6-Chloro-2-methylthio-4-pyrimidinamine;6-chloro-2-methylthiopyrimidin-4-ylamine;4-AMINO-6-CHLORO-2-(METHYLTHIO)PYRIMIDINE;2-(Methylthio)-6-chloropyrimidine-4-amine;4-Pyrimidinamine, 6-chloro-2-(methylthio)-;6-AMINO-4-CHLORO-2-METHYLMERCAPTOPYRIMIDINE
CBNumber:
CB6171009
Molecular Formula:
C5H6ClN3S
Molecular Weight:
175.64
MDL Number:
MFCD00006088
MOL File:
1005-38-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:22:33
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4-Amino-6-chloro-2-(methylthio)pyrimidine Properties

Melting point 130-132 °C (lit.)
Boiling point 338.7±22.0 °C(Predicted)
Density 1.395 (estimate)
refractive index 1.6100 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Methanol
form Crystalline Powder
pka 1.11±0.10(Predicted)
color Off-white to beige or yellow
InChI 1S/C5H6ClN3S/c1-10-5-8-3(6)2-4(7)9-5/h2H,1H3,(H2,7,8,9)
InChIKey ISUXMAHVLFRZQU-UHFFFAOYSA-N
SMILES CSc1nc(N)cc(Cl)n1
CAS DataBase Reference 1005-38-5(CAS DataBase Reference)
FDA UNII P8SND49KYK
NIST Chemistry Reference Pyrimidine, 4-amino-6-chloro-2-(methylthio)-(1005-38-5)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
target organs Respiratory system
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  37/39-26
WGK Germany  3
HS Code  29335990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

4-Amino-6-chloro-2-(methylthio)pyrimidine price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A46005 4-Amino-6-chloro-2-(methylthio)pyrimidine 97% 1005-38-5 5g $93.4 2023-01-07 Buy
Sigma-Aldrich A46005 4-Amino-6-chloro-2-(methylthio)pyrimidine 97% 1005-38-5 25g $444 2023-01-07 Buy
TCI Chemical A2848 4-Amino-6-chloro-2-(methylthio)pyrimidine >98.0%(GC)(T) 1005-38-5 5g $50 2026-04-30 Buy
TCI Chemical A2848 4-Amino-6-chloro-2-(methylthio)pyrimidine >98.0%(GC)(T) 1005-38-5 25g $356 2021-12-16 Buy
Biosynth FA31528 4-Amino-6-chloro-2-(methylthio) pyrimidine 1005-38-5 25g $150 2026-06-04 Buy
Product number Packaging Price Buy
A46005 5g $93.4 Buy
A46005 25g $444 Buy
A2848 5g $50 Buy
A2848 25g $356 Buy
FA31528 25g $150 Buy

4-Amino-6-chloro-2-(methylthio)pyrimidine Chemical Properties, Uses, Production

Uses

4-Amino-6-chloro-2-(methylthio)pyrimidine is a halogenated heterocycle, a useful synthesis intermediate.

Chemical Properties

off-white to beige or yellow crystalline powder

Uses

4-Amino-6-chloro-2-(methylthio)pyrimidine is a halogenated heterocycle, a useful synthesis intermediate.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 1098, 1955 DOI: 10.1021/ja01610a006

Synthesis

4,6-Dichloro-2-(methylthio)pyrimidine

6299-25-8

4-Amino-6-chloro-2-(methylthio)pyrimidine

1005-38-5

General procedure for the synthesis of 4-amino-6-chloro-2-(methylthio)pyrimidine from 4,6-dichloro-2-(methylthio)pyrimidine: 1. 4,6-Dichloro-2-(methylthio)pyrimidine was added slowly in a 2L autoclave with THF and ammonia. 2. The reaction mixture was heated to 50-60°C and kept at that temperature for 3-4 hours (pressure in the reactor was maintained at 7-8 Kg/cm2). 3. The progress of the reaction was monitored by TLC. 4. After completion of the reaction, the reaction mixture was cooled to 25-35°C. 5. 5. Concentrate the reaction mixture under vacuum. 6. 6. Hexane was added and stirred at 25-35 °C for 30-45 min. 7. Collect the solid product by filtration and wash with hexane. 8. Wash the solid product with water (2 x 400 mL). 9. Dry the solid product at 25-35 °C until the moisture content (MC) is less than 2%. Yield: 352.0 g. Yield: 97.77%. HPLC purity: 99.07%. Note: For different analogs, other suitable conditions may be used, such as the use of methanol or dioxane solutions of ammonia. Example 1-2: Preparation of 4-amino-6-chloro-2-methylthiopyrimidine, step 6.1.

References

[1] Patent: WO2011/97594, 2011, A2. Location in patent: Page/Page column 100-101
[2] Chemistry - A European Journal, 1999, vol. 5, # 12, p. 3450 - 3458
[3] Patent: WO2007/141571, 2007, A2. Location in patent: Page/Page column 25
[4] American Chemical Journal, 1904, vol. 32, p. 353
[5] Patent: US2005/288502, 2005, A1. Location in patent: Page/Page column 20

4-Amino-6-chloro-2-(methylthio)pyrimidine Preparation Products And Raw materials

Raw materials

4-Amino-2-(methylthio)-6-pyrimidinol 4,6-Dichloro-2-(methylthio)pyrimidine Ammonia Tetrahydrofuran

Preparation Products

4-Amino-6-chloro-2-(methylthio)pyrimidine Suppliers

Global Suppliers ( 198)
Supplier Tel Email Country ProdList Advantage
Jinan Huicheng Pharm Tech Co., Ltd. 1566-575-0038 13258035297 info@huipharm.com China 44 58
Shanghai Enong Biotechnology Co., LTD 15821616017 2507465308@qq.com China 89 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ChangShu Haitian Fine Chemicals Co.,Ltd 13913622609 974295387@qq.com China 192 61
Shangchem Co., Ltd. +86-21-68182121 China 881 52
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Supplier Advantage
Jinan Huicheng Pharm Tech Co., Ltd. 58
Shanghai Enong Biotechnology Co., LTD 58
J & K SCIENTIFIC LTD. 76
PharmaBlock Sciences (Nanjing),Inc. 55
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ChangShu Haitian Fine Chemicals Co.,Ltd 61
Shangchem Co., Ltd. 52
Pure Chemistry Scientific Inc. 62

View Latest Price from 4-Amino-6-chloro-2-(methylthio)pyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Amino-6-chloro-2-(methylthio)pyrimidine pictures 2026-09-02 4-Amino-6-chloro-2-(methylthio)pyrimidine
1005-38-5
 $1.00-200.00 1KG 99%, 99.5% Sublimated Henan Fengda Chemical Co., Ltd
4-Amino-6-chloro-2-(methylthio)pyrimidine pictures 2026-08-20 4-Amino-6-chloro-2-(methylthio)pyrimidine
1005-38-5
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
4-Amino-6-chloro-2-(methylthio)pyrimidine pictures 2022-04-25 4-Amino-6-chloro-2-(methylthio)pyrimidine
1005-38-5
 98%min 10kgs/month Shanghai Rlavie Technology Co ltd

4-Amino-6-chloro-2-(methylthio)pyrimidine Spectrum

4-Amino-6-chloro-2-(methylthio)pyrimidine(1005-38-5)MS4-Amino-6-chloro-2-(methylthio)pyrimidine(1005-38-5)1HNMR4-Amino-6-chloro-2-(methylthio)pyrimidine(1005-38-5)13CNMR4-Amino-6-chloro-2-(methylthio)pyrimidine(1005-38-5)IR14-Amino-6-chloro-2-(methylthio)pyrimidine(1005-38-5)IR24-Amino-6-chloro-2-(methylthio)pyrimidine(1005-38-5)Raman

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1of4

4-Pyrimidinamine, 6-chloro-2-(methylthio)- 6-Chloro-2-(methylsulfanyl)-4-pyrimidinylamine U 8342 2-METHYLMERCAPTO-4-AMINO-AMINO-6-CHLOROPYRIMIDINE 4-AMINO-6-CHLORO-2-METHYLMERCAPTOPYRIMIDINE 4-AMINO-6-CHLORO-2-(METHYLTHIO)PYRIMIDINE 6-AMINO-4-CHLORO-2-METHYLMERCAPTOPYRIMIDINE TIMTEC-BB SBB003786 6-chloro-2-methylthiopyrimidin-4-ylamine 1-[butoxy(phenyl)methyl]piperidine JR-8886, 4-Amino-6-chloro-2(methylthio)pyrimidine, 97% 4-AMINO-6-CHLORO-2-METHYLMERCAPTOPYRIMIDINE 97% 4-Amino-6-chloro-2-(methylthio)pyrimidine ,98% 4-Amino-6-chloro-2-methylmercaptopyrimidine ,98% 2-(Methylthio)-6-chloropyrimidine-4-amine 6-Chloro-2-methylthio-4-pyrimidinamine 4-Amino-6-chloro-2-methylmercaptopyrimidine,97% 6-chloro-2-methylsulfanylpyrimidin-4-yl amine 4-Amino-6-chloro-2-(methylthio)pyrimidine> 4-Amino-6-chloro-2-(methylthio)pyrimidine ISO 9001：2015 REACH 6-CHLORO-2-(METHYLTHIO)PYRIMIDIN-4-AMINE 1005-38-5 C5H6ClN3S Heterocyclic Building Blocks Halogenated Heterocycles Pyrimidines HETERO CHLORIDE Building Blocks Building Blocks C4 to C5 Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyrimidines PyrimidinesHeterocyclic Building Blocks Heterocycle-Pyrimidine series Sulphur Derivatives