Bis(tri-tert-butylphosphine)palladium(0)
- CAS No.
- 53199-31-8
- Chemical Name:
- Bis(tri-tert-butylphosphine)palladium(0)
- Synonyms
- Pd(t-Bu3P)2;BIS(TRI-TERT-BUTYLPHOSPHINE)PALLADIUM;BIS(TRI-T-BUTYLPHOSPHINE)PALLADIUM(0);Pd(P(t-Bu)3)2;Bis[tris(tert-butyl)phosphine]palladium;Bis[tris(tert-butyl)phosphine]palladium, 20.9% Pd;bis(tri-tert-butylphosphane) palladium;BIS(TRI-TERT-BUTYLPHOSPHINE)PALLADIUM (0);bis(tri-tert-butylphosphoranyl)palladium;Bis(t
- CBNumber:
- CB6181345
- Molecular Formula:
- C24H56P2Pd
- Molecular Weight:
- 513.08
- MDL Number:
- MFCD03094580
- MOL File:
- 53199-31-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >300 °C |
|---|---|
| storage temp. | -20°C |
| form | Crystals |
| color | Off-white to orange-brown |
| Water Solubility | insoluble |
| Sensitive | Light, Air & Moisture Sensitive |
| InChI | InChI=1S/2C12H27P.Pd/c2*1-10(2,3)13(11(4,5)6)12(7,8)9;/h2*1-9H3;/q;;-2/p+2 |
| InChIKey | XULQKWNZCKOVSU-UHFFFAOYSA-P |
| SMILES | P(C(C)(C)C)(C(C)(C)C)(C(C)(C)C)[Pd]P(C(C)(C)C)(C(C)(C)C)C(C)(C)C |
| CAS DataBase Reference | 53199-31-8(CAS DataBase Reference) |
| UNSPSC Code | 12161600 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | No | |||||||||
| HS Code | 28439000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Bis(tri-tert-butylphosphine)palladium(0) price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 676578 | Bis(tri-tert-butylphosphine)palladium(0) | 53199-31-8 | 250mg | $143 | 2026-04-30 | Buy |
| Sigma-Aldrich | 676578 | Bis(tri-tert-butylphosphine)palladium(0) | 53199-31-8 | 1g | $285 | 2026-04-30 | Buy |
| TCI Chemical | B3161 | Bis(tri-tert-butylphosphine)palladium(0) >98.0%(T) | 53199-31-8 | 1g | $265 | 2026-04-30 | Buy |
| TCI Chemical | B3161 | Bis(tri-tert-butylphosphine)palladium(0) >98.0%(T) | 53199-31-8 | 250mg | $85 | 2026-04-30 | Buy |
| Strem Chemicals | 46-0252 | Bis(tri-t-butylphosphine)palladium(0), 98% 98% | 53199-31-8 | 250mg | $106 | 2026-04-30 | Buy |
Bis(tri-tert-butylphosphine)palladium(0) Chemical Properties, Uses, Production
Synthesis
In a dry reaction flask, [Pd(allyl)Cl]₂ (1.91 g, 5.2 mmol) was dissolved in a dry acetonitrile solution (350 mL). Then, in a nitrogen-filled glove box, tri-tert-butylphosphine (6.54 g) was added to the palladium complex in one go. After stirring the reaction mixture for a period of time, a turbid yellow solution formed. Within a few minutes, the reaction mixture slowly became opaque. Stirring the reaction mixture for another 18 h yielded a milky white mixture. After the reaction was complete, the crude reaction mixture was filtered through a medium-sized filter, and the solid product was collected. The solid was washed with acetonitrile (3 × 50 mL) and dried under vacuum to obtain di(tri-tert-butylphosphine)palladium.
Figure 2. Synthetic Route of Bis(tri-tert-butylphosphine)palladium(0)
Reaction
- Introduced as an easier to handle Pd/P(t-Bu)3-based catalyst for the Negishi cross-coupling of aryl/vinyl chlorides.
- A versatile catalyst for the cross-coupling of aryl and vinyl chlorides.
- Catalyst for the amination of aryl chlorides and bromides using aqueous hydroxide bases.
- Useful catalyst for the cross-coupling of heteroaromatic carboxylic acids.
- Pd-catalyzed Newnan-Kwart rearrangement of O-aryl thiocarbamates.
- Cross-coupling of silanolates and halides.
- Elimination/isomerization of enol triflates derived from β-ketoesters.
Chemical Properties
Off white crystalline solid
Uses
Catalyst for Suzuki coupling on a multisubstituted sp 3 -carbon (eq. 1) Catalyst for Stille coupling reaction of aryl chlorides 2 (eq. 2) Catalyst for Negishi coupling reaction 3 (eq. 3) Catalyst for Heck coupling to form tetrasubstituted olefins 4 (eq. 4) Catalyst for Buchwald-Hartwig amination of aryl halide 5 (eq. 5) Catalyst for carbonylation of aryl halides with carbamoylsilanes 6 (eq. 6) t -Bu 3 P) 2 catalyst.
Uses
Bis(tri-tert-butylphosphine)palladium(0) is used in Coupling reactions, Heck couplings. It acts as a palladium catalyst for reductive carbonylation.
General Description
This product has been enhanced for catalytic efficiency.
reaction suitability
core: palladium
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Cross Couplings
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst
Bis(tri-tert-butylphosphine)palladium(0) Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Rock New Materials Co., Ltd. | 0917-8888777 18691786767 | liuwei@bjrock.com | China | 309 | 62 |
| Anhui Weihe Chemical Technology Co., Ltd. | 13505592528 13505592528 | 49141484@qq.com | China | 2671 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from Bis(tri-tert-butylphosphine)palladium(0) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | Bis(tri-t-butylphosphine)palladium
53199-31-8
|
$2.00-5.00 | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |||
 |
2021-06-11 | Bis(tri-t-butylphosphine)palladium(0) / Pd(t-Bu3P)2
53199-31-8
|
$10.00 | 1g | 0.98 | 50kg | Wuhan LPBchem Technology Co.,Ltd | |
 |
2020-11-16 | Bis(tri-tert-butylphosphine)palladium(0)
53199-31-8
|
$20.00 | 1KG | 99% | 10000KG | Longyan Tianhua Biological Technology Co., Ltd |
-
- Bis(tri-t-butylphosphine)palladium
53199-31-8
- $2.00-5.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- Bis(tri-t-butylphosphine)palladium(0) / Pd(t-Bu3P)2
53199-31-8
- $10.00
- 0.98
- Wuhan LPBchem Technology Co.,Ltd
-
- Bis(tri-tert-butylphosphine)palladium(0)
53199-31-8
- $20.00
- 99%
- Longyan Tianhua Biological Technology Co., Ltd
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