4-Chloro-5-fluoroindole
- CAS No.
- 169674-02-6
- Chemical Name:
- 4-Chloro-5-fluoroindole
- Synonyms
- 4-Chloro-5-fluoroindole;4-chloro-5-fluoro-1H-indole;1H-Indole, 4-chloro-5-fluoro-
- CBNumber:
- CB61874684
- Molecular Formula:
- C8H5ClFN
- Molecular Weight:
- 169.58
- MDL Number:
- MFCD12924664
- MOL File:
- 169674-02-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P280-P302+P352-P362+P364 |
| HS Code | 2933998090 |
4-Chloro-5-fluoroindole price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC201168 | 4-Chloro-5-fluoro-1H-indole 97% | 169674-02-6 | 100mg | $73 | 2026-06-04 | Buy |
| Apolloscientific | PC201168 | 4-Chloro-5-fluoro-1H-indole 97% | 169674-02-6 | 250mg | $177 | 2026-06-04 | Buy |
| Apolloscientific | PC201168 | 4-Chloro-5-fluoro-1H-indole 97% | 169674-02-6 | 1g | $558 | 2026-06-04 | Buy |
| Matrix Scientific | 296751 | 4-Chloro-5-fluoro-1H-indole | 169674-02-6 | 100.00mg | $65 | 2026-05-19 | Buy |
| Matrix Scientific | 296751 | 4-Chloro-5-fluoro-1H-indole | 169674-02-6 | 250.00mg | $161 | 2026-05-19 | Buy |
4-Chloro-5-fluoroindole Chemical Properties,Uses,Production
Synthesis
![1H-Indole, 4-chloro-5-fluoro-1-[tris(1-methylethyl)silyl]-](/CAS/20210305/GIF/908600-95-3.gif)
908600-95-3
169674-02-6
The general procedure for the synthesis of 4-chloro-5-fluoroindole using the compound (CAS: 908600-95-3) as starting material was as follows: tetrabutylammonium fluoride hydrate (1.9 g, 7.38 mmol) was dissolved in THF (30 mL) along with compound 2 (1.2 g, 3.69 mmol), and the reaction was stirred for 30 min at room temperature. After completion of the reaction, the reaction mixture was diluted with ether (30 mL), followed by washing with brine (30 mL), drying with anhydrous sodium sulfate, filtering to remove the desiccant, and the filtrate was concentrated under reduced pressure to remove the solvent. Finally, purification by column chromatography (eluent: petroleum ether/ethyl acetate = 50:1) afforded compound 3 (0.5 g, 80.1% yield) as a brown oil.
References
[1] European Journal of Organic Chemistry, 2006, # 13, p. 2956 - 2969
[2] Patent: US2016/9706, 2016, A1. Location in patent: Paragraph 0354; 0357
4-Chloro-5-fluoroindole Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloro-5-fluoroindole Suppliers
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