5-Chloro-2-methoxybenzaldehyde
- CAS No.
- 7035-09-8
- Chemical Name:
- 5-Chloro-2-methoxybenzaldehyde
- Synonyms
- AKOS B014153;ASISCHEM R42152;ART-CHEM-BB B014153;CHEMBRDG-BB 3014153;5-Chloro-2-Anisaldehyde;5-Chloro-2-methoxybenzaldehyde;Benzaldehyde, 5-chloro-2-methoxy-;2-Bromo-5-(trifluoromethyl)acetophenone;JR-13439, 5-Chloro-2-methoxybenzaldehyde, 97%;5-chloro-2-methoxybenzaldehyde(SALTDATA: FREE)
- CBNumber:
- CB6214511
- Molecular Formula:
- C8H7ClO2
- Molecular Weight:
- 170.59
- MDL Number:
- MFCD00033854
- MOL File:
- 7035-09-8.mol
- MSDS File:
- SDS
| Melting point | 75-79℃ |
|---|---|
| Boiling point | 152 °C(Press: 15 Torr) |
| Density | 1.244±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| Appearance | White to light yellow Solid |
| Sensitive | Air Sensitive |
| InChI | InChI=1S/C8H7ClO2/c1-11-8-3-2-7(9)4-6(8)5-10/h2-5H,1H3 |
| InChIKey | HXTWDGGMXZXOIV-UHFFFAOYSA-N |
| SMILES | C(=O)C1=CC(Cl)=CC=C1OC |
| CAS DataBase Reference | 7035-09-8(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280g-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-36-51 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2913000090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Chronic 2 Eye Irrit. 2 |
|||||||||
| NFPA 704 |
|
5-Chloro-2-methoxybenzaldehyde price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS005116 | 5-Chloro-2-methoxybenzaldehyde AldrichCPR | 7035-09-8 | 100mg | $77.9 | 2026-04-30 | Buy |
| Biosynth | FC70984 | 5-Chloro-2-methoxybenzaldehyde | 7035-09-8 | 10g | $150 | 2026-06-04 | Buy |
| Biosynth | FC70984 | 5-Chloro-2-methoxybenzaldehyde | 7035-09-8 | 25g | $204.5 | 2026-06-04 | Buy |
| Biosynth | FC70984 | 5-Chloro-2-methoxybenzaldehyde | 7035-09-8 | 50g | $363 | 2026-06-04 | Buy |
| Biosynth | FC70984 | 5-Chloro-2-methoxybenzaldehyde | 7035-09-8 | 100g | $637 | 2026-06-04 | Buy |
5-Chloro-2-methoxybenzaldehyde Chemical Properties, Uses, Production
Synthesis Reference(s)
Synthetic Communications, 19, p. 799, 1989 DOI: 10.1080/00397918908050996
Synthesis
635-93-8
74-88-4
7035-09-8
Step 1: Preparation of 5-chloro-2-methoxybenzaldehyde 5-Chloro-2-hydroxybenzaldehyde (20 g, 128 mmol) was dissolved in N,N-dimethylformamide (DMF, 70 mL) and the solution was cooled to 5-10 °C. Sodium hydride (7.69 g, 192 mmol) was added to the solution in small portions over 20 min. Subsequently, iodomethane (23.8 mL, 384 mmol) was added dropwise while keeping the temperature of the reaction mixture below 15 °C. After addition, the reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the mixture was poured into pre-cooled saturated ammonium chloride solution (250 mL) and a white precipitate precipitated. The precipitate was collected by filtration and dried under vacuum. The resulting solid was ground with a solvent mixture of pentane and ether (4:1, 100 mL) to afford 18 g (82.58% yield) of the target product, 5-chloro-2-methoxybenzaldehyde, as a white solid.LC-MS analysis showed m/z = 170.1 ([M+H]+).
References
[1] Chemical Communications, 2011, vol. 47, # 9, p. 2679 - 2681
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 12, p. 5019 - 5032
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 12, p. 2768 - 2776
[4] Patent: WO2014/151472, 2014, A1. Location in patent: Paragraph 00392-00393
[5] Patent: WO2016/40315, 2016, A1. Location in patent: Paragraph 00435; 00436
5-Chloro-2-methoxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Wuhan Arike Technology Co., Ltd. | 027- 51832457 94518350 | China | 746 | 62 | |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
View Latest Price from 5-Chloro-2-methoxybenzaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 5-CHLORO-2-METHOXYBENZALDEHYDE
7035-09-8
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-05-12 | 5-Chloro-2-methoxybenzaldehyde
7035-09-8
|
1kg | 98% | 2 MTs | PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD |
-
- 5-CHLORO-2-METHOXYBENZALDEHYDE
7035-09-8
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 5-Chloro-2-methoxybenzaldehyde
7035-09-8
- $0.00
- 98%
- PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
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