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2'-Hydroxy-5'-methoxyacetophenone

2'-Hydroxy-5'-methoxyacetophenone Structure
2'-Hydroxy-5'-methoxyacetophenone structure
CAS No.
705-15-7
Chemical Name:
2'-Hydroxy-5'-methoxyacetophenone
Synonyms
1-(2-HYDROXY-5-METHOXYPHENYL)ETHAN-1-ONE;1-(2-HYDROXY-5-METHOXYPHENYL)ETHANONE;Ethanone, 1-(2-hydroxy-5-methoxyphenyl)-;2-HYDROXY-5-METHOXYACETOPHENONE;2'-Hydro;NSC 338218;ASISCHEM D38760;sulfosulfamic acid;5-Methoxy-2-hydroxyacetophenone;2'-Hydroxy-5'-methoxyacetophene
CBNumber:
CB6234562
Molecular Formula:
C9H10O3
Molecular Weight:
166.17
MDL Number:
MFCD00008731
MOL File:
705-15-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:40:05
Product description Number Pack Size Price
2′-Hydroxy-5′-methoxyacetophenone 99% 114995 5g $71.6
2′-Hydroxy-5′-methoxyacetophenone 99% 114995 25g $172
2'-Hydroxy-5'-methoxyacetophenone >98.0%(GC) H0868 5g $18
2'-Hydroxy-5'-methoxyacetophenone >98.0%(GC) H0868 25g $81
2-Hydroxy-5-methoxyacetophenone 99+% ≥99% 230412 5g $170
More product size
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2'-Hydroxy-5'-methoxyacetophenone Properties

Melting point 52 °C(lit.)
Boiling point 254.38°C (rough estimate)
Density 1.1708 (rough estimate)
refractive index 1.5500 (estimate)
Flash point >230 °F
storage temp. Inert atmosphere,Room Temperature
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka 10.65±0.18(Predicted)
form Crystalline Powder
color Yellow
Odor Aromatic, somewhat medicinal, warm, woody -the herbaceous odour of good tenacity.
λmax 355 nm
BRN 1239364
InChI 1S/C9H10O3/c1-6(10)8-5-7(12-2)3-4-9(8)11/h3-5,11H,1-2H3
InChIKey MLIBGOFSXXWRIY-UHFFFAOYSA-N
SMILES COc1ccc(O)c(c1)C(C)=O
CAS DataBase Reference 705-15-7(CAS DataBase Reference)
NIST Chemistry Reference Ethanone, 1-(2-hydroxy-5-methoxyphenyl)-(705-15-7)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H315-H318-H335
Precautionary statements  P261-P280-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  37/38-41-36/37/38
Safety Statements  26-37/39-36/37/39-22
WGK Germany  3
Hazard Note  Irritant
HS Code  29145090
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Dam. 1
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2'-Hydroxy-5'-methoxyacetophenone price More Price(78)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 114995 2′-Hydroxy-5′-methoxyacetophenone 99% 705-15-7 5g $71.6 2026-04-30 Buy
Sigma-Aldrich 114995 2′-Hydroxy-5′-methoxyacetophenone 99% 705-15-7 25g $172 2026-04-30 Buy
TCI Chemical H0868 2'-Hydroxy-5'-methoxyacetophenone >98.0%(GC) 705-15-7 5g $18 2026-04-30 Buy
TCI Chemical H0868 2'-Hydroxy-5'-methoxyacetophenone >98.0%(GC) 705-15-7 25g $81 2026-04-30 Buy
Usbiological 230412 2-Hydroxy-5-methoxyacetophenone 99+% ≥99% 705-15-7 5g $170 2026-06-03 Buy
Product number Packaging Price Buy
114995 5g $71.6 Buy
114995 25g $172 Buy
H0868 5g $18 Buy
H0868 25g $81 Buy
230412 5g $170 Buy

2'-Hydroxy-5'-methoxyacetophenone Chemical Properties,Uses,Production

Chemical Properties

yellow crystalline powder

Uses

2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols. 2-Hydroxy-5-methoxyacetophenone is also used to prepare substituted chromanone and chromone derivatives as sirtuin 2-selective inhibitors.

Application

2'-Hydroxy-5'-methoxyacetophenone could find some use in perfume compositions, e. g., in artificial Oakmoss, in New Mown Hay fragrances, and in certain heavy florals. It blends well with Labdanum and with Lavender type oils, and it lends a certain amount of power and undertones to the fragrance.

Preparation

reparation by reaction of dimethyl sulfate on 2,5-dihydroxyacetophenone, with potassium carbonate in acetone at r.t. (74%) ; with aqueous sodium hydroxide solution at reflux (35%).

Synthesis Reference(s)

Synthesis, p. 901, 1985 DOI: 10.1055/s-1985-31380

General Description

2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols.

Synthesis

Dimethyl sulfate

77-78-1

2',5'-Dihydroxyacetophenone

490-78-8

2'-Hydroxy-5'-methoxyacetophenone

705-15-7

To a suspension of 2,5-dihydroxyacetophenone (100 mg, 0.66 mmol) and potassium carbonate (95 mg, 0.69 mmol) was added dimethyl sulfate (87 mg, 0.69 mmol) and the reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was filtered and concentrated under reduced pressure. The resulting residue was treated with 2N NaOH aqueous solution and subsequently extracted with EtOAc. The organic layers were combined, washed with saturated saline, dried over anhydrous MgSO4 and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with hexane-EtOAc (10:1, v/v) as eluent to afford 2'-hydroxy-5'-methoxyacetophenone in 40% yield as a colorless oil.1H NMR (400 MHz, CDCl3) δ: 11.9 (s, 1H), 7.18 (d, J = 2.8 Hz, 1H), 7.12 (dd, J = 8.8, 2.8 Hz, 1H), 6.93 (d, J = 8.8 Hz, 1H), 3.81 (s, 3H), 2.63 (s, 3H).

References

[1] Journal of the Chinese Chemical Society, 2004, vol. 51, # 6, p. 1389 - 1394
[2] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 1143 - 1152
[3] Journal fuer Praktische Chemie (Leipzig), 1937, vol. <2> 149, p. 324,325
[4] Journal of the Indian Chemical Society, 1990, vol. 67, # 6, p. 478 - 481
[5] European Journal of Medicinal Chemistry, 2009, vol. 44, # 6, p. 2552 - 2562

2'-Hydroxy-5'-methoxyacetophenone Preparation Products And Raw materials

Raw materials

1-(2-hydroxy-3-methoxy-phenyl)ethanone 3-METHOXYPHENYL ACETATE 3-Methoxyacetophenone Acetic anhydride Acetic acid p-methoxyphenyl ester
Dimethyl sulfate 2',5'-Dihydroxyacetophenone 4-Methoxyphenol

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Preparation Products

2'-Hydroxy-5'-methoxyacetophenone Suppliers

Global( 285)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29812 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19936 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 +86-17392587031 1059@dideu.com China 9996 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
career henan chemical co 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
BOC Sciences 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Hefei Hirisun Pharmatech Co., Ltd 		58

View Lastest Price from 2'-Hydroxy-5'-methoxyacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2'-Hydroxy-5'-methoxyacetophenone pictures 2026-05-11 2'-Hydroxy-5'-methoxyacetophenone
705-15-7
 $29.00 99.50% 10g TargetMol Chemicals Inc.
2'-Hydroxy-5'-methoxyacetophenone pictures 2024-04-23 2'-Hydroxy-5'-methoxyacetophenone
705-15-7
 $950.00 1Kg 98 500 Kg R&D Scientific Inc.
2'-Hydroxy-5'-methoxyacetophenone pictures 2019-07-06 2'-Hydroxy-5'-methoxyacetophenone
705-15-7
 $1.00 1KG 99% Career Henan Chemical Co

2'-Hydroxy-5'-methoxyacetophenone Spectrum

2'-Hydroxy-5'-methoxyacetophenone(705-15-7)1HNMR2'-Hydroxy-5'-methoxyacetophenone(705-15-7)FT-IR2'-Hydroxy-5'-methoxyacetophenone(705-15-7)IR2'-Hydroxy-5'-methoxyacetophenone(705-15-7)Raman

705-15-7(2'-Hydroxy-5'-methoxyacetophenone)Related Search:

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5-Methoxy-2-hydroxyacetophenone Acetophenone, 2'-hydroxy-5'-methoxy- 1-(2-HYDROXY-5-METHOXYPHENYL)ETHANONE 2-HYDROXY-5'-METHOXYACETOPHENONE 2-HYDROXY-5-METHOXYACETOPHENONE 2'-HYDROXY-5'-METHOXYACETYLPHENONE ASISCHEM D38760 2'-Hydroxy-5'-methoxyacetophenone 99% NSC 338218 2'-HYDROXY-5'-METHOXYACETOPHENONE,99% 2'-Hydro 2'-Hydroxy-5'-methoxyacetophene JR-6832, 1-(2-Hydroxy-5-methoxyphenyl)ethanone, 97% sulfosulfamic acid 2'-Hydroxy-5'-methoxyacetophenone> 2'-Hydroxy-5'-methoxyacetophenone 2''-Hydroxy-5''-methoxyacetophenone 2''-Hydroxy-5''-methoxyacetophenone, 10 mM in DMSO 2′-Hydroxy-5′-methoxyacetophenone, CAS 705-15-7 1-(2-HYDROXY-5-METHOXYPHENYL)ETHAN-1-ONE Ethanone, 1-(2-hydroxy-5-methoxyphenyl)- 705-15-7 Building Blocks Carbonyl Compounds C9 Ketones Organic Building Blocks ketone| alcohol Aromatic Acetophenones & Derivatives (substituted) C9 Carbonyl Compounds Ketones