2'-Hydroxy-5'-methoxyacetophenone
- CAS No.
- 705-15-7
- Chemical Name:
- 2'-Hydroxy-5'-methoxyacetophenone
- Synonyms
- 1-(2-HYDROXY-5-METHOXYPHENYL)ETHAN-1-ONE;1-(2-HYDROXY-5-METHOXYPHENYL)ETHANONE;Ethanone, 1-(2-hydroxy-5-methoxyphenyl)-;2-HYDROXY-5-METHOXYACETOPHENONE;2'-Hydro;NSC 338218;ASISCHEM D38760;sulfosulfamic acid;5-Methoxy-2-hydroxyacetophenone;2'-Hydroxy-5'-methoxyacetophene
- CBNumber:
- CB6234562
- Molecular Formula:
- C9H10O3
- Molecular Weight:
- 166.17
- MDL Number:
- MFCD00008731
- MOL File:
- 705-15-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 52 °C(lit.) |
|---|---|
| Boiling point | 254.38°C (rough estimate) |
| Density | 1.1708 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| Flash point | >230 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| pka | 10.65±0.18(Predicted) |
| form | Crystalline Powder |
| color | Yellow |
| Odor | Aromatic, somewhat medicinal, warm, woody -the herbaceous odour of good tenacity. |
| λmax | 355 nm |
| BRN | 1239364 |
| InChI | 1S/C9H10O3/c1-6(10)8-5-7(12-2)3-4-9(8)11/h3-5,11H,1-2H3 |
| InChIKey | MLIBGOFSXXWRIY-UHFFFAOYSA-N |
| SMILES | COc1ccc(O)c(c1)C(C)=O |
| CAS DataBase Reference | 705-15-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethanone, 1-(2-hydroxy-5-methoxyphenyl)-(705-15-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 37/38-41-36/37/38 | |||||||||
| Safety Statements | 26-37/39-36/37/39-22 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29145090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2'-Hydroxy-5'-methoxyacetophenone price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 114995 | 2′-Hydroxy-5′-methoxyacetophenone 99% | 705-15-7 | 5g | $71.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | 114995 | 2′-Hydroxy-5′-methoxyacetophenone 99% | 705-15-7 | 25g | $172 | 2026-04-30 | Buy |
| TCI Chemical | H0868 | 2'-Hydroxy-5'-methoxyacetophenone >98.0%(GC) | 705-15-7 | 5g | $18 | 2026-04-30 | Buy |
| TCI Chemical | H0868 | 2'-Hydroxy-5'-methoxyacetophenone >98.0%(GC) | 705-15-7 | 25g | $81 | 2026-04-30 | Buy |
| Usbiological | 230412 | 2-Hydroxy-5-methoxyacetophenone 99+% ≥99% | 705-15-7 | 5g | $170 | 2026-06-03 | Buy |
2'-Hydroxy-5'-methoxyacetophenone Chemical Properties,Uses,Production
Chemical Properties
yellow crystalline powder
Uses
2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols. 2-Hydroxy-5-methoxyacetophenone is also used to prepare substituted chromanone and chromone derivatives as sirtuin 2-selective inhibitors.
Application
2'-Hydroxy-5'-methoxyacetophenone could find some use in perfume compositions, e. g., in artificial Oakmoss, in New Mown Hay fragrances, and in certain heavy florals. It blends well with Labdanum and with Lavender type oils, and it lends a certain amount of power and undertones to the fragrance.
Preparation
reparation by reaction of dimethyl sulfate on 2,5-dihydroxyacetophenone, with potassium carbonate in acetone at r.t. (74%) ; with aqueous sodium hydroxide solution at reflux (35%).
Synthesis Reference(s)
Synthesis, p. 901, 1985 DOI: 10.1055/s-1985-31380
General Description
2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols.
Synthesis
77-78-1
490-78-8
705-15-7
To a suspension of 2,5-dihydroxyacetophenone (100 mg, 0.66 mmol) and potassium carbonate (95 mg, 0.69 mmol) was added dimethyl sulfate (87 mg, 0.69 mmol) and the reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was filtered and concentrated under reduced pressure. The resulting residue was treated with 2N NaOH aqueous solution and subsequently extracted with EtOAc. The organic layers were combined, washed with saturated saline, dried over anhydrous MgSO4 and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with hexane-EtOAc (10:1, v/v) as eluent to afford 2'-hydroxy-5'-methoxyacetophenone in 40% yield as a colorless oil.1H NMR (400 MHz, CDCl3) δ: 11.9 (s, 1H), 7.18 (d, J = 2.8 Hz, 1H), 7.12 (dd, J = 8.8, 2.8 Hz, 1H), 6.93 (d, J = 8.8 Hz, 1H), 3.81 (s, 3H), 2.63 (s, 3H).
References
[1] Journal of the Chinese Chemical Society, 2004, vol. 51, # 6, p. 1389 - 1394
[2] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 1143 - 1152
[3] Journal fuer Praktische Chemie (Leipzig), 1937, vol. <2> 149, p. 324,325
[4] Journal of the Indian Chemical Society, 1990, vol. 67, # 6, p. 478 - 481
[5] European Journal of Medicinal Chemistry, 2009, vol. 44, # 6, p. 2552 - 2562
2'-Hydroxy-5'-methoxyacetophenone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Taijilin Industrial Co., Ltd. | 02150630626 17717886015 | kate@tajilin.com | China | 1340 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Lastest Price from 2'-Hydroxy-5'-methoxyacetophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | 2'-Hydroxy-5'-methoxyacetophenone
705-15-7
|
$29.00 | 99.50% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-04-23 | 2'-Hydroxy-5'-methoxyacetophenone
705-15-7
|
$950.00 | 1Kg | 98 | 500 Kg | R&D Scientific Inc. | |
 |
2019-07-06 | 2'-Hydroxy-5'-methoxyacetophenone
705-15-7
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 2'-Hydroxy-5'-methoxyacetophenone
705-15-7
- $29.00
- 99.50%
- TargetMol Chemicals Inc.
-
- 2'-Hydroxy-5'-methoxyacetophenone
705-15-7
- $950.00
- 98
- R&D Scientific Inc.
-
- 2'-Hydroxy-5'-methoxyacetophenone
705-15-7
- $1.00
- 99%
- Career Henan Chemical Co
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