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Lycorine hydrochloride

Lycorine hydrochloride Structure
Lycorine hydrochloride structure
CAS No.
2188-68-3
Chemical Name:
Lycorine hydrochloride
Synonyms
LYCORINE;LYCORIN;(-)-LYCORINE;NARCISSIN(P);Lycorine chloride;Hydrochloric Lycorine;Licorin hydrochloride;Lycorine hydrochloride;Licorine hydrochloride;Amarylline hydrochloride
CBNumber:
CB6415905
Molecular Formula:
C16H17NO4.ClH
Molecular Weight:
323.77
MDL Number:
MFCD00243111
MOL File:
2188-68-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
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Lycorine hydrochloride Properties

Melting point 206 °C
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Soluble in water (15 mg/ml)
form powder
color White to off-white
Stability Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
InChI 1S/C16H17NO4.ClH/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19;/h3-5,11,14-16,18-19H,1-2,6-7H2;1H/t11-,14-,15+,16+;/m0./s1
InChIKey VUVNTYCHKZBOMV-NVJKKXITSA-N
SMILES Cl.O[C@H]1C=C2CCN3Cc4cc5OCOc5cc4[C@H]([C@@H]1O)[C@@H]23
FDA UNII 58F70VH0HS
UNSPSC Code 12352202
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310-P405-P501
PPE Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral

Lycorine hydrochloride price More Price(60)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L5139 Lycorine hydrochloride ≥98% (TLC), powder 2188-68-3 20mg $397 2026-04-30 Buy
Usbiological 300599 Lycorine hydrochloride (Lycorine chloride) ≥98% 2188-68-3 20mg $263 2026-06-03 Buy
TRC TRC-L487550-50MG Lycorine Hydrochloride 2188-68-3 50mg $209 2026-06-03 Buy
TRC TRC-L487550-500MG Lycorine Hydrochloride 2188-68-3 500mg $1547 2026-06-03 Buy
TRC TRC-L487550-20MG Lycorine Hydrochloride 2188-68-3 20mg $154 2026-06-03 Buy
Product number Packaging Price Buy
L5139 20mg $397 Buy
300599 20mg $263 Buy
TRC-L487550-50MG 50mg $209 Buy
TRC-L487550-500MG 500mg $1547 Buy
TRC-L487550-20MG 20mg $154 Buy

Lycorine hydrochloride Chemical Properties, Uses, Production

Description

Lycorine (2188-68-3) arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 μM).4A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Lycoris radiata bulbs.

Uses

Lycorine Hydrochloride is the main phenanthridine Amaryllidaceae alkaloid which exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli.

Biochem/physiol Actions

A selective inhibitor of peptidyl transferase center (PTC). In HL-60 (leukemia) cells, lycorine arrests the cell cycle at G2/M and induces apoptosis by a caspase-mediated pathway.

in vivo

Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry[1].

Animal Model:6- to 8-week-old BALB/C nude mice[1]
Dosage:0 μg, 7.5 μg, 15 μg
Administration:Subcutaneous injection; for 14 days
Result:Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.

References

[1] GIEDRIUS MILIAUSKAS. Identification of Radical Scavenging Compounds in Rhaponticum carthamoides by Means of LC-DAD-SPE-NMR[J]. Journal of Natural Products , 2005, 68 2: 168-172. DOI:10.1021/np0496901
[2] JIANGNING LIU. Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication.[J]. Virology Journal, 2011: 483. DOI:10.1186/1743-422x-8-483
[3] YOSHIAKI ONISHI Y Y Yasuhiro Kawano. Lycorine, a candidate for the control of period length in mammalian cells.[J]. Cellular Physiology and Biochemistry, 2012, 29 3-4: 407-416. DOI:10.1159/000338495
[4] ZHIFEI CAO . Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity[J]. Toxicology letters, 2013, 218 2: Pages 174-185. DOI:10.1016/j.toxlet.2013.01.018
[5] LIANGDE ZHENG. The Paf1 complex transcriptionally regulates the mitochondrial-anchored protein Atg32 leading to activation of mitophagy.[J]. Autophagy, 2019. DOI:10.1080/15548627.2019.1668228

Lycorine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,4,5,7,12b,12c-hexahydro-, 1-acetate, (1S,2S,12bS,12cS)-

Lycorine hydrochloride Suppliers

Global Suppliers ( 309)
Supplier Tel Email Country ProdList Advantage
Nanjing Spring & Autumn Biological Engineering Co., Ltd. 17388075642 13815430202 sale02@cqherb.com China 261 59
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
XiaoGan ShenYuan ChemPharm co,ltd 15527621225; 15527621225 1791901229@qq.com China 6742 52
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Sichuan Kulinan Technology Co., Ltd 400-1166-196 18981987031 cdhxsj@163.com China 11674 57
Hunan Hui Bai Shi Biotechnology Co., Ltd. 0731-85526065 13308475853 ivy@hnhbsj.com China 7236 62
Shenzhen Sungening Bio-Tech Co., Ltd +86-0755-89668383 sales@sungening.com China 1319 65
Supplier Advantage
Nanjing Spring & Autumn Biological Engineering Co., Ltd. 59
J & K SCIENTIFIC LTD. 76
Chembest Research Laboratories Limited 61
Nanjing Chemlin Chemical Co., Ltd 64
Chemsky（shanghai）International Co.,Ltd. 50
XiaoGan ShenYuan ChemPharm co,ltd 52
Shandong Xiya Chemical Co., Ltd 57
Sichuan Kulinan Technology Co., Ltd 57
Hunan Hui Bai Shi Biotechnology Co., Ltd. 62
Shenzhen Sungening Bio-Tech Co., Ltd 65

View Latest Price from Lycorine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Lycorine hydrochloride pictures 2026-09-11 Lycorine hydrochloride
2188-68-3
 1KG 98% HPLC 1000KG Changsha Staherb Natural Ingredients Co., Ltd.
Lycorine hydrochloride USP/EP/BP pictures 2026-08-20 Lycorine hydrochloride USP/EP/BP
2188-68-3
 $1.10 1g 99.9% 100 Tons Min Dideu Industries Group Limited
Lycorine hydrochloride pictures 2026-08-12 Lycorine hydrochloride
2188-68-3
 $3175.00 1KG 98% 1000kg Baoji Guokang Healthchem Co., Ltd.

Lycorine hydrochloride Spectrum

Lycorine hydrochloride(2188-68-3)MS

2188-68-3 (Lycorine hydrochloride) Related Search:

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Lycorine Hydrochloride98% Licorin hydrochloride Hydrochloric Lycorine LYCORIN (-)-LYCORINE 1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol,2,4,5,7,12b,12c-hexahydro-, hydrochloride (1:1), (1S,2S,12bS,12cS)- NARCISSIN(P) (1S,2S,12BS,12CS)-1,2,4,5,12B,12C-HEXAHYDRO-7H-[1,3]DIOXOLO[4,5-J]PYRROLO[3,2,1-DE]PHENANTHRIDINE-1,2-DIOL Lycorine hydrochloride Lycorine chloride Lycorinehydrochloride 2188-68-3 Lycorine chloride 2188-68-3 Lycorine hydrochloride, 96%(HPLC) Amarylline hydrochloride Galanthidine hydrochloride Licorine hydrochloride Narcissine hydrochloride Lycorine hydrochloride USP/EP/BP (1S,2S,3a1S,12bS)-2,3a1,4,5,7,12b-Hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol hydrochloride (1S,2S,12bS,12cS)-2,4,5,7,12b,12c-hexahydro-1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol hydrochloride (1:1) (1R,17S,18R,19S)-5,7-Dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol Lycorine hydrochloride 98% (1S,2S,12bS,12cS)-2,4,5,7,12b,12C-Hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol HCl LYCORINE 2188-68-3 C16H17NO4HCl Cell Signaling and Neuroscience Cell Biology BioChemical Gene Regulation and Expression RNA-Protein Translation Inhibitors Inhibitors chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Peptidyl transferaseCell Signaling and Neuroscience Enzyme Inhibitors by Enzyme Gene Regulation and Expression P to RNA-Protein Translation Inhibitors