4-Trifluoromethylsalicylic acid
- CAS No.
- 328-90-5
- Chemical Name:
- 4-Trifluoromethylsalicylic acid
- Synonyms
- 2-HYDROXY-4-(TRIFLUOROMETHYL)BENZOIC ACID;RARECHEM AL BE 1424;Desacetyl Triflusal;Triflusal Impurity 1;Triflusal EP Impurity B;Trifluoromethylsalicylicacid;p-Trifluoromethylsalicylicacid;4-(TRIFLUOROMETHY)SALICYLIC ACID;4- threefluorine Methylsalicylate;α,α,α-Trifluoro-2,4-cresotic Acid
- CBNumber:
- CB6245300
- Molecular Formula:
- C8H5F3O3
- Molecular Weight:
- 206.12
- MDL Number:
- MFCD01529657
- MOL File:
- 328-90-5.mol
- MSDS File:
- SDS
| Melting point | 178 °C |
|---|---|
| Boiling point | 286.4±40.0 °C(Predicted) |
| Density | 1.539±0.06 g/cm3(Predicted) |
| vapor pressure | 0.013-0.076Pa at 25℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 2.45±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C8H5F3O3/c9-8(10,11)4-1-2-5(7(13)14)6(12)3-4/h1-3,12H,(H,13,14) |
| InChIKey | XMLFPUBZFSJWCN-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(C(F)(F)F)C=C1O |
| LogP | 3.21 |
| CAS DataBase Reference | 328-90-5(CAS DataBase Reference) |
| FDA UNII | UKY7YRE9E9 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29189900 | |||||||||
| NFPA 704 |
|
4-Trifluoromethylsalicylic acid price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T2005010 | Triflusal impurity B European Pharmacopoeia (EP) Reference Standard | 328-90-5 | 15 mg | $118 | 2025-07-31 | Buy |
| Sigma-Aldrich | T2005010 | Triflusal impurity B European Pharmacopoeia (EP) Reference Standard | 328-90-5 | t2005010 | $150 | 2024-03-01 | Buy |
| TCI Chemical | T2064 | 4-(Trifluoromethyl)salicylic Acid >98.0%(GC)(T) | 328-90-5 | 5g | $31 | 2025-07-31 | Buy |
| TCI Chemical | T2064 | 4-(Trifluoromethyl)salicylic Acid >98.0%(GC)(T) | 328-90-5 | 25g | $46 | 2025-07-31 | Buy |
| TRC | D288765 | DesacetylTriflusal | 328-90-5 | 25g | $315 | 2021-12-16 | Buy |
4-Trifluoromethylsalicylic acid Chemical Properties,Uses,Production
Chemical Properties
White to off-white solid
Uses
The active metabolite of Triflusal; inhibits cardiac hypertrophy in vitro and in vivo by blocking the NF-κB signaling pathway.
Definition
ChEBI: 2-Hydroxy-4-trifluoromethyl benzoic acid is a hydroxybenzoic acid. It is functionally related to a salicylic acid.
Synthesis
455-24-3
328-90-5
General procedure for the synthesis of 2-hydroxy-4-(trifluoromethyl)benzoic acid from 4-trifluoromethylbenzoic acid: III. Pd(II)-catalyzed tert-butyl hydroxylation reaction (General Method 02): Pd(OAc)2 (11.2 mg, 0.05 mmol), 4-trifluoromethylbenzoic acid (0.5 mmol), benzoquinone (54.0 mg, 0.5 mmol), KOAc (98.0 mg, 1 mmol), and N,N-dimethylacetamide (1.5 mL) were added to a 50 mL high-pressure reactor, and the unit was equipped with a magnetic stir bar. After filling the reactor with O2 (20 atm), it was evacuated and filled again with O2 (5 atm, repeated twice). The reaction mixture was stirred at 115 °C for 15 h and subsequently cooled to room temperature. Post-reaction treatment and purification of the crude product was carried out as described previously for hydroxylation under 1 atm O2 conditions.
References
[1] Journal of the American Chemical Society, 2009, vol. 131, # 41, p. 14654 - 14655
[2] Patent: WO2011/37929, 2011, A2. Location in patent: Page/Page column 14; 19-20
4-Trifluoromethylsalicylic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | abby@chuanghaibio.com | China | 8773 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 | sales@hbmojin.com | China | 12374 | 58 |
| Changzhou Rokechem Technology Co., Ltd. | 18758118018 | sales001@rokechem.com | China | 255 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20191 | 58 |
| Hebei Junhua Import and Export Co., LTD | +86-18503288844 | junhua1@hb-junhua.com | China | 957 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 12932 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21622 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
View Lastest Price from 4-Trifluoromethylsalicylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-11 | 4-Trifluoro Methyl Salicylic Acid
328-90-5
|
US $0.00 / kg | 1kg | 98% | 1000 | Hebei Junhua Import and Export Co., LTD | |
 |
2025-09-11 | 4-Trifluoromethylsalicylic acid
328-90-5
|
US $0.00-0.00 / Kg/Drum | 1KG | 99%min | 500KGS | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-08-08 | 4-Trifluoromethylsalicylic acid
328-90-5
|
US $500.00 / g | 100g | 99% | 200ton | Hebei Mujin Biotechnology Co.,Ltd |
-
- 4-Trifluoro Methyl Salicylic Acid
328-90-5
- US $0.00 / kg
- 98%
- Hebei Junhua Import and Export Co., LTD
-
- 4-Trifluoromethylsalicylic acid
328-90-5
- US $0.00-0.00 / Kg/Drum
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 4-Trifluoromethylsalicylic acid
328-90-5
- US $500.00 / g
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
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