TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
- CAS No.
- 216064-48-1
- Chemical Name:
- TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
- Synonyms
- 2-Boc-5-hydroxy-1,2,3,4-tetrahydroisoquinoline;N-BOC-1,2,3,4-tetrahydro-5-hydeoxy-isoquinoline;TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLAT;tert-butyl 5-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylate;TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE;Tert-Butyl 5-hydroxy-3,4-dihydro-2(1H)-iso quinoline carboxylate;2-tert-butyloxycarbonyl-5-hydroxy-1,2,3,4-tetrahydroisoquinoline;tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 95+%;5-Hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester;2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-5-hydroxy-, 1,1-dimethylethyl ester
- CBNumber:
- CB6258733
- Molecular Formula:
- C14H19NO3
- Molecular Weight:
- 249.31
- MDL Number:
- MFCD08275037
- MOL File:
- 216064-48-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate | 066676 | 1g | $289 |
| tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate | 4H56-1-378 | 1g | $303 |
| tert-Butyl5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate | 0992AB | 500mg | $337 |
| tert-Butyl5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 95+% | OR318035 | 1g | $441 |
| TERT-BUTYL-5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 97.00% | CHM0166476 | 1G | $748.44 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| HazardClass | IRRITANT |
| HS Code | 2933491090 |
TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 066676 | tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate | 216064-48-1 | 1g | $289 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H56-1-378 | tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate | 216064-48-1 | 1g | $303 | 2021-12-16 | Buy |
| AK Scientific | 0992AB | tert-Butyl5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate | 216064-48-1 | 500mg | $337 | 2021-12-16 | Buy |
| Apolloscientific | OR318035 | tert-Butyl5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 95+% | 216064-48-1 | 1g | $441 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0166476 | TERT-BUTYL-5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 97.00% | 216064-48-1 | 1G | $748.44 | 2021-12-16 | Buy |
TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Chemical Properties,Uses,Production
Synthesis
24424-99-5
2439-04-5
216064-48-1
(1) Platinum oxide (100 mg) was added to a solution of 5-hydroxyisoquinoline (2.9 g, 20 mmol) in acetic acid (30 mL) and the hydrogenation reaction was carried out at room temperature and atmospheric pressure. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. The residue was crystallized by toluene (20 mL) and collected by filtration. The resulting crystals were dissolved in a solvent mixture of 1 N aqueous sodium hydroxide (40 mL) and tetrahydrofuran (40 mL), followed by addition of di-tert-butyl dicarbonate (4.8 g, 22 mmol). The reaction mixture was stirred at room temperature for 1 h, after which 1 N hydrochloric acid (40 mL) was added. Extraction was carried out with ether, the extract was dried over anhydrous magnesium sulfate and the solvent was removed by evaporation under reduced pressure. The precipitated crystals were recrystallized by diisopropyl ether to give colorless crystals of 2-tert-butoxycarbonyl-5-hydroxy-tetrahydroisoquinoline (2.9 g, 58% yield). Melting point: 163-164 °C. 1H-NMR (CDCl3) δ: 1.49 (9H, s), 2.76 (2H, t, J = 6.0 Hz).
References
[1] Patent: EP1123918, 2001, A1
[2] Patent: WO2016/108045, 2016, A2. Location in patent: Page/Page column 29
TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39002 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Carbott PharmTech Inc. | 0535-6385396 | info@carbottpharm.com | China | 973 | 56 |
View Lastest Price from TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-03 | TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
216064-48-1
|
US $1.00 / KG | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
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- TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
216064-48-1
- US $1.00 / KG
- 95-99%
- Career Henan Chemical Co
