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ChemicalBook >> CAS DataBase List >>tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate Structure
tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate structure
CAS No.
216064-48-1
Chemical Name:
tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate
Synonyms
2-Boc-5-hydroxy-1,2,3,4-tetrahydroisoquinoline;N-BOC-1,2,3,4-tetrahydro-5-hydeoxy-isoquinoline;TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLAT;tert-butyl 5-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylate;tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate;Tert-Butyl 5-hydroxy-3,4-dihydro-2(1H)-iso quinoline carboxylate;2-tert-butyloxycarbonyl-5-hydroxy-1,2,3,4-tetrahydroisoquinoline;tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 95+%;5-Hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester;2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-5-hydroxy-, 1,1-dimethylethyl ester
CBNumber:
CB6258733
Molecular Formula:
C14H19NO3
Molecular Weight:
249.31
MDL Number:
MFCD08275037
MOL File:
216064-48-1.mol
MSDS File:
SDS
Last updated:2026-09-12 18:54:08
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tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate Properties

Boiling point 378.6±42.0 °C(Predicted)
Density 1.170±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 9.96±0.20(Predicted)
Appearance Off-white to light brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
HazardClass  IRRITANT
HS Code  2933491090

tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth RIA06448 tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 216064-48-1 5g $649 2026-06-05 Buy
Biosynth RIA06448 tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 216064-48-1 10g $1038.4 2026-06-05 Buy
Biosynth RIA06448 tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 216064-48-1 25g $2076.75 2026-06-05 Buy
Biosynth RIA06448 tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 216064-48-1 50g $3764 2026-06-05 Buy
Biosynth RIA06448 tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 216064-48-1 100g $6879 2026-06-05 Buy
Product number Packaging Price Buy
RIA06448 5g $649 Buy
RIA06448 10g $1038.4 Buy
RIA06448 25g $2076.75 Buy
RIA06448 50g $3764 Buy
RIA06448 100g $6879 Buy

tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate Chemical Properties,Uses,Production

Synthesis

Di-tert-butyl dicarbonate

24424-99-5

5-Hydroxyisoquinoline

2439-04-5

TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE

216064-48-1

(1) Platinum oxide (100 mg) was added to a solution of 5-hydroxyisoquinoline (2.9 g, 20 mmol) in acetic acid (30 mL) and the hydrogenation reaction was carried out at room temperature and atmospheric pressure. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. The residue was crystallized by toluene (20 mL) and collected by filtration. The resulting crystals were dissolved in a solvent mixture of 1 N aqueous sodium hydroxide (40 mL) and tetrahydrofuran (40 mL), followed by addition of di-tert-butyl dicarbonate (4.8 g, 22 mmol). The reaction mixture was stirred at room temperature for 1 h, after which 1 N hydrochloric acid (40 mL) was added. Extraction was carried out with ether, the extract was dried over anhydrous magnesium sulfate and the solvent was removed by evaporation under reduced pressure. The precipitated crystals were recrystallized by diisopropyl ether to give colorless crystals of 2-tert-butoxycarbonyl-5-hydroxy-tetrahydroisoquinoline (2.9 g, 58% yield). Melting point: 163-164 °C. 1H-NMR (CDCl3) δ: 1.49 (9H, s), 2.76 (2H, t, J = 6.0 Hz).

References

[1] Patent: EP1123918, 2001, A1
[2] Patent: WO2016/108045, 2016, A2. Location in patent: Page/Page column 29

tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate 5-Hydroxyisoquinoline Tetrahydrofuran Hydrochloric acid Sodium hydroxide
Acetic acid

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Preparation Products

tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate Suppliers

Global( 66)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
Carbott PharmTech Inc. 0535-6385396 info@carbottpharm.com China 996 56
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Chengdu Forest Science and Technology Development Co., Ltd. 18030648795 18030648795 sales@cdforestchem.com China 1998 58
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
SynAsst Chemical. 021-60343070 China 12731 55
Shanghai Raise Chemical Technology Co.,Ltd +86-021-50935922 China 7854 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Supplier Advantage
J & K SCIENTIFIC LTD. 76
PharmaBlock Sciences (Nanjing),Inc. 55
Carbott PharmTech Inc. 56
Wuhan Chemwish Technology Co., Ltd 56
Nanjing Chemlin Chemical Co., Ltd 64
Chengdu Forest Science and Technology Development Co., Ltd. 58
Shanghai Topbiochem Technology Co., Ltd 58
SynAsst Chemical. 55
Shanghai Raise Chemical Technology Co.,Ltd 55
Bide Pharmatech Ltd. 60

View Lastest Price from tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE pictures 2020-01-03 TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
216064-48-1
 $1.00 1KG 95-99% 1ton Career Henan Chemical Co

tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate Spectrum

TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE(216064-48-1)1HNMR

216064-48-1(tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate)Related Search:

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2-tert-butyloxycarbonyl-5-hydroxy-1,2,3,4-tetrahydroisoquinoline N-BOC-1,2,3,4-tetrahydro-5-hydeoxy-isoquinoline 5-Hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-5-hydroxy-, 1,1-dimethylethyl ester tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 95+% tert-butyl 5-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylate TERT-BUTYL 5-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLAT 2-Boc-5-hydroxy-1,2,3,4-tetrahydroisoquinoline Tert-Butyl 5-hydroxy-3,4-dihydro-2(1H)-iso quinoline carboxylate tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 216064-48-1