N-Chlorophthalimide
- CAS No.
- 3481-09-2
- Chemical Name:
- N-Chlorophthalimide
- Synonyms
- ncp;2-Chloroisoindoline-1,3-dione;Chlorophtalimide;N-Chlorphthalimid;N-CHLOROPHTHALIMIDE;phthalimide chloride;Phthalimidoyl chloride;N-Chlorophthalimide,95%;N-Chlorophthalimide 96%;N-Chlorophthalimide
- CBNumber:
- CB6265755
- Molecular Formula:
- C8H4ClNO2
- Molecular Weight:
- 181.58
- MDL Number:
- MFCD00023027
- MOL File:
- 3481-09-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| N-Chlorophthalimide 96% | 528218 | 25g | $113 |
| N-Chlorophthalimide >95.0%(T) | C0802 | 25g | $48 |
| N-Chlorophthalimide >95.0%(T) | C0802 | 500g | $285 |
| N-Chlorophthalimide ≥95%(HPLC) | 37232 | 25G | $36.65 |
| N-Chlorophthalimide ≥95%(HPLC) | 37232 | 100G | $105.36 |
| Melting point | 188-198 °C (lit.) |
|---|---|
| Boiling point | 315.1±25.0 °C(Predicted) |
| Density | 1.56±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -3.53±0.20(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| InChI | InChI=1S/C8H4ClNO2/c9-10-7(11)5-3-1-2-4-6(5)8(10)12/h1-4H |
| InChIKey | WDRFYIPWHMGQPN-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C=CC=C2)C(=O)N1Cl |
| CAS DataBase Reference | 3481-09-2(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 1759 | |||||||||
| WGK Germany | 1 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
N-Chlorophthalimide price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 528218 | N-Chlorophthalimide 96% | 3481-09-2 | 25g | $113 | 2026-04-30 | Buy |
| TCI Chemical | C0802 | N-Chlorophthalimide >95.0%(T) | 3481-09-2 | 25g | $48 | 2026-04-30 | Buy |
| TCI Chemical | C0802 | N-Chlorophthalimide >95.0%(T) | 3481-09-2 | 500g | $285 | 2026-04-30 | Buy |
| Chem-Impex | 37232 | N-Chlorophthalimide ≥95%(HPLC) | 3481-09-2 | 25G | $36.65 | 2026-05-19 | Buy |
| Chem-Impex | 37232 | N-Chlorophthalimide ≥95%(HPLC) | 3481-09-2 | 100G | $105.36 | 2026-05-19 | Buy |
N-Chlorophthalimide Chemical Properties,Uses,Production
Chemical Properties
White to pale yellow powder
Uses
N-Chlorophthalimide may be employed in the synthesis of:
- α-amino acetal
- α-amino nitro compounds
- vicinal diamine
- α,β-unsaturated vicinal haloamino nitro compound
General Description
N-Chlorophthalimide in anhydrous acetic acid serves as a useful oxidizing reagent for use in various direct titrimetric analyses. N-Chlorophthalimide can be synthesized by reacting phthalimide, t-butyl hypochlorite, water and t-butyl alcohol. It participates in the synthesis of 2-amino-3-benzoyl-α-(methylthio)phenylacetamide.
Synthesis
136918-14-4
3481-09-2
General procedure for the synthesis of N-chlorophthalimide from 3-hydroxy-1H-isoindol-1-one: Anhydrous aluminum trichloride (AlCl3, 1 eq., 10 mmol, 1.36 g) was added to an anhydrous acetonitrile (CH3CN, 100 mL) solution of lead tetraacetate (Pb(OAc)4, 1 eq., 10 mmol, 4.52 g). The mixture was stirred at room temperature for 5 minutes before phthalimide (1 eq., 10 mmol, 1.5 g) was added. The resulting mixture was gently refluxed under nitrogen protection for 20 h and subsequently cooled to room temperature. The solvent was removed by rotary evaporation and the crude product was purified by column chromatography using pure dichloromethane (DCM) as eluent. Yield: 1.32 g, 71% yield.1H NMR (300 MHz, CDCl3): δ 7.94-7.91 (m, 2H), 7.82-7.79 (m, 2H) ppm.
References
[1] Synthesis, 2009, # 16, p. 2797 - 2801
[2] Synlett, 2006, # 2, p. 194 - 200
[3] Catalysis Today, 2018, vol. 308, p. 94 - 101
[4] Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 6, p. 1302
[5] Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 8, p. 163
N-Chlorophthalimide Preparation Products And Raw materials
Raw materials
Preparation Products
N-Chlorophthalimide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 4000 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5233 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30226 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | sale03@alfachem.cn | China | 9733 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
View Lastest Price from N-Chlorophthalimide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-26 | N-Chlorophthalimide
3481-09-2
|
US $30.00-10.00 / kg | 10kg | 99% | 100000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2024-07-11 | N-Chlorophthalimide
3481-09-2
|
US $1.00 / KG | 1KG | 98% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- N-Chlorophthalimide
3481-09-2
- US $30.00-10.00 / kg
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- N-Chlorophthalimide
3481-09-2
- US $1.00 / KG
- 98%
- Shaanxi Dideu Medichem Co. Ltd
