(S)-5-(Bromomethyl)-2-pyrrolidinone
- CAS No.
- 72479-05-1
- Chemical Name:
- (S)-5-(Bromomethyl)-2-pyrrolidinone
- Synonyms
- (S)-5-(BromomethyL;5β-(Bromomethyl)pyrrolidine-2-one;(S)-5-(BROMOMETHYL)-2-PYRROLIDONE;(S)-5-BROMOMETHYL-2-OXOPYRROLIDINE;(5S)-5-(Brommethyl)pyrrolidin-2-on;(S)-5-(broMoMethyl)pyrrolidin-2-one;(S)-5-(Bromomethyl)-2-pyrrolidinone;(5S)-5-(bromomethyl)-2-pyrrolidinone;(5S)-5-(broMoMethyl)pyrrolidin-2-one;(5S)-5β-(Bromomethyl)pyrrolidine-2-one
- CBNumber:
- CB6312743
- Molecular Formula:
- C5H8BrNO
- Molecular Weight:
- 178.03
- MDL Number:
- MFCD01632456
- MOL File:
- 72479-05-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 75-79°C |
|---|---|
| Boiling point | 102-106 °C(Press: 0.1 Torr) |
| Density | 1.541±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 15.39±0.40(Predicted) |
| form | powder |
| Appearance | Off-white to light brown Solid |
| optical activity | [α]22/D 30.0°, c = 0.5 in ethanol |
| InChI | 1S/C5H8BrNO/c6-3-4-1-2-5(8)7-4/h4H,1-3H2,(H,7,8)/t4-/m0/s1 |
| InChIKey | QFOSFXPTXNRRMF-BYPYZUCNSA-N |
| SMILES | BrC[C@@H]1CCC(=O)N1 |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H317-H319 |
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-43-36-22 |
| Safety Statements | 26-36/37/39-36/37 |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Sens. 1 |
(S)-5-(Bromomethyl)-2-pyrrolidinone price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 715611 | (S)-5-(Bromomethyl)-2-pyrrolidinone 96% | 72479-05-1 | 250mg | $59.2 | 2023-06-20 | Buy |
| AstaTech | 54799 | (S)-5-BROMOMETHYL-2-OXOPYRROLIDINE 97% | 72479-05-1 | 1G | $46 | 2026-04-30 | Buy |
| AstaTech | 54799 | (S)-5-BROMOMETHYL-2-OXOPYRROLIDINE 97% | 72479-05-1 | 5G | $210 | 2026-04-30 | Buy |
| AstaTech | 54799 | (S)-5-BROMOMETHYL-2-OXOPYRROLIDINE 97% | 72479-05-1 | 10G | $411 | 2026-04-30 | Buy |
| Chem-Impex | 41530 | (S)-5-(Bromomethyl)-2-pyrrolidinone ≥95.5%(GC) | 72479-05-1 | 250MG | $61.19 | 2026-05-19 | Buy |
(S)-5-(Bromomethyl)-2-pyrrolidinone Chemical Properties, Uses, Production
Chemical Properties
White to tan powder
Synthesis
17342-08-4
72479-05-1
General procedure for the synthesis of (S)-5-bromomethyl-2-pyrrolidinone from (S)-(+)-5-hydroxymethyl-2-pyrrolidinone: First, (S)-5-hydroxymethyl-2-pyrrolidinone (1.58 g, 13.7 mmol) and triphenylphosphine (3.97 g, 15.1 mmol) were suspended in anhydrous acetonitrile (20 mL) and stirred at 0 °C. Subsequently, a solution of carbon tetrabromide (5.02 g, 15.1 mmol, 1.1 eq.) dissolved in 8 mL of anhydrous acetonitrile was added slowly and dropwise. The reaction mixture gradually changed to a clarified solution, followed by stirring at room temperature overnight. Upon completion of the reaction, the solvent was removed by rotary evaporation and the residue was purified by Biotage fast chromatography to afford the target product (S)-5-bromomethyl-2-pyrrolidinone as a white solid (2.32 g, 95% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CD3OD): δ 6.18 (br s, 1H), 3.94-3.97 (m, 1H), 3.28-3.44 (m, 2H), 2.27-2.49 (m, 3H), 1.82-1.91 (m, 1H).
References
[1] Helvetica Chimica Acta, 1996, vol. 79, # 4, p. 961 - 972
[2] Patent: WO2012/21712, 2012, A1. Location in patent: Page/Page column 162
[3] Journal of Organic Chemistry, 1980, vol. 45, # 5, p. 815 - 818
[4] Journal of the American Chemical Society, 1990, vol. 112, # 2, p. 838 - 845
[5] Tetrahedron, 2013, vol. 69, # 27-28, p. 5647 - 5659
(S)-5-(Bromomethyl)-2-pyrrolidinone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanbu County Chengxin Technology Co., Ltd. | 0838-5675166 15883665058 | nbcxkj@126.com | China | 956 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
View Latest Price from (S)-5-(Bromomethyl)-2-pyrrolidinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | (S)-5-(BROMOMETHYL)-2-PYRROLIDINONE
72479-05-1
|
$1.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- (S)-5-(BROMOMETHYL)-2-PYRROLIDINONE
72479-05-1
- $1.00
- 98%
- Career Henan Chemical Co
