4-Ethoxy-3-fluorophenylboronic acid
- CAS No.
- 279263-10-4
- Chemical Name:
- 4-Ethoxy-3-fluorophenylboronic acid
- Synonyms
- AKOS BRN-0575;4-Ethoxy-3-fL;4-Borono-2-fluorophenetole;4-Ethoxy-3-Fluorophenylboronic;(4-ethyl-2-thiophenyl)boronic acid;4-Ethoxy-3-fluorophenylboronic acid;3-FLUORO-4-ETHOXYBENZENEBORONIC ACID;4-ETHOXY-3-FLUOROBENZENEBORONIC ACID;Boronic acid, B-(4-ethoxy-3-fluorophenyl)-;4-Ethoxy-3-fluorophenylboronic Acid (contains varying amounts of Anhydride)
- CBNumber:
- CB6338044
- Molecular Formula:
- C8H10BFO3
- Molecular Weight:
- 183.97
- MDL Number:
- MFCD04115667
- MOL File:
- 279263-10-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 108-113 C |
|---|---|
| Boiling point | 328.1±52.0 °C(Predicted) |
| Density | 1.22±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 7.90±0.10(Predicted) |
| color | White to Almost white |
| CAS DataBase Reference | 279263-10-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2931900090 | |||||||||
| NFPA 704 |
|
4-Ethoxy-3-fluorophenylboronic acid price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E1124 | 4-Ethoxy-3-fluorophenylboronic Acid (contains varying amounts of Anhydride) | 279263-10-4 | 1g | $21 | 2026-04-30 | Buy |
| TCI Chemical | E1124 | 4-Ethoxy-3-fluorophenylboronic Acid (contains varying amounts of Anhydride) | 279263-10-4 | 5g | $70 | 2026-04-30 | Buy |
| Apolloscientific | PC2669 | 4-Ethoxy-3-fluorobenzeneboronic acid ≥95% | 279263-10-4 | 1g | $21 | 2026-06-04 | Buy |
| Activate Scientific | AS143642 | 4-Ethoxy-3-fluorophenylboronic Acid 98% | 279263-10-4 | 1g | $24 | 2026-06-04 | Buy |
| Activate Scientific | AS143642 | 4-Ethoxy-3-fluorophenylboronic Acid 98% | 279263-10-4 | 5g | $40 | 2026-06-04 | Buy |
4-Ethoxy-3-fluorophenylboronic acid Chemical Properties,Uses,Production
Uses
suzuki reaction
Synthesis
121-43-7
115467-08-8
279263-10-4
General procedure for the synthesis of 4-ethoxy-3-fluorophenylboronic acid from trimethyl borate and 4-bromo-2-fluorophenylethyl ether: 4-bromo-2-fluorophenylethyl ether (43.8 g) was dissolved in dry tetrahydrofuran (400 ml) and the resulting solution was cooled down to -70 °C. Under nitrogen protection, n-butyllithium (133 ml) was slowly added dropwise and the reaction was stirred at -70 °C for 2 hours. Subsequently, a dry tetrahydrofuran solution of trimethyl borate (64.8 g) was slowly added at the same temperature. The reaction solution was gradually warmed to room temperature and stirring was continued for 16 hours. Upon completion of the reaction, the reaction was quenched by the addition of 2N hydrochloric acid (200 ml) and the reaction mixture was extracted with toluene. The organic layer was washed sequentially with water and saturated aqueous sodium chloride solution and then dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to give a light brown solid. Purification by recrystallization (heptane: toluene=4:1, v/v) gave colorless crystals of 4-ethoxy-3-fluorophenylboronic acid (23.9 g, yield: 65%).
References
[1] Patent: EP2484658, 2012, A1. Location in patent: Page/Page column 44
4-Ethoxy-3-fluorophenylboronic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
4-Ethoxy-3-fluorophenylboronic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chembon Pharmaceutical Co., Ltd. | 028-84252981 18583719936 | sales@chembon.com.cn | China | 854 | 64 |
| Xi’an chemsoar Medical Technology Co., ltd | 029-86538357 | China | 234 | 57 | |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
View Lastest Price from 4-Ethoxy-3-fluorophenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 4-ETHOXY-3-FLUOROPHENYLBORONIC ACID
279263-10-4
|
$1.00 | 1KG | 97%-99% | 1kg; 5kg; 100kg | Career Henan Chemical Co |
-
- 4-ETHOXY-3-FLUOROPHENYLBORONIC ACID
279263-10-4
- $1.00
- 97%-99%
- Career Henan Chemical Co
279263-10-4(4-Ethoxy-3-fluorophenylboronic acid)Related Search:
1of4
