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4-Bromo-2-fluorophenol

4-Bromo-2-fluorophenol structure

CAS No.: 2105-94-4

Chemical Name:: 4-Bromo-2-fluorophenol

Synonyms: 4-Bromo-2-fluorophen;4-Brom-2-Fluorphenol;2-Fluor-4 bromophenol;2-Fluoro-4-BroMophonel;2-Fluoro-4-Bromophenol;4-BROMO-2-FLUOROPHENOL;2-Bromo-2-fluorophenol;4-Bromo-2-fluorophenol98%;Phenol, 4-bromo-2-fluoro-;4-Bromo-2-fluorophenol >

CBNumber:: CB6257615

Molecular Formula:: C6H4BrFO

Molecular Weight:: 191

MDL Number:: MFCD00011722

MOL File:: 2105-94-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:58:34

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4-Bromo-2-fluorophenol Properties

Boiling point	79 °C/7 mmHg (lit.)
Density	1.744 g/mL at 25 °C (lit.)
refractive index	n20/D 1.566(lit.)
Flash point	210 °F
storage temp.	Inert atmosphere,Room Temperature
form	Liquid
pka	8.14±0.18(Predicted)
Specific Gravity	1.744
color	Clear colorless to brown
BRN	1861281
InChI	InChI=1S/C6H4BrFO/c7-4-1-2-6(9)5(8)3-4/h1-3,9H
InChIKey	RYVOZMPTISNBDB-UHFFFAOYSA-N
SMILES	C1(O)=CC=C(Br)C=C1F
CAS DataBase Reference	2105-94-4(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332-H315-H319-H335

Precautionary statements

P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501-P280a-P304+P340-P305+P351+P338-P405-P501a

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-22

Safety Statements

26-37/39-36/37/39

WGK Germany

HazardClass

IRRITANT

HS Code

29071990

Storage Class

10 - Combustible liquids

REACH Registrations

Inactive

NFPA 704

	0
2		0

4-Bromo-2-fluorophenol price More Price(71)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	316296	4-Bromo-2-fluorophenol 98%	2105-94-4	5g	$25	2023-01-07	Buy
Sigma-Aldrich	316296	4-Bromo-2-fluorophenol 98%	2105-94-4	25g	$60.8	2023-01-07	Buy
TCI Chemical	B1835	4-Bromo-2-fluorophenol >98.0%(GC)	2105-94-4	5g	$29	2026-04-30	Buy
TCI Chemical	B1835	4-Bromo-2-fluorophenol >98.0%(GC)	2105-94-4	25g	$87	2026-04-30	Buy
Biosynth	FB61831	4-Bromo-2-fluorophenol	2105-94-4	50g	$150	2026-06-04	Buy

Product number	Packaging	Price	Buy
316296	5g	$25	Buy
316296	25g	$60.8	Buy
B1835	5g	$29	Buy
B1835	25g	$87	Buy
FB61831	50g	$150	Buy

4-Bromo-2-fluorophenol Chemical Properties, Uses, Production

Chemical Properties

CLEAR COLORLESS TO BROWNISH LIQUID

Uses

4-Bromo-2-fluorophenol can be used as a starting material for the synthesis of:

4-Bromo-2-fluoro-6-iodoanisole via iodination and methylation.
2-Phenylpyran-4-ones for active cyclooxygenase-2 inhibitor evaluation.
1,4-Disubstituted 3-cyano-2-pyridones.
Dicationic imidazolium-based compounds.

Synthesis

367-12-4

2105-94-4

Example 5: Preparation of methyl 2-[4-(4-bromo-2-fluorophenoxy)phenoxy]propionate (STR29) 1. 2-Fluorophenol (22.4 g, 0.2 mol) was dissolved in dichloromethane (250 mL) under ice bath conditions and cooled to about 3 °C. 2. 2. bromine (31.97 g, 0.2 mol) was added slowly, keeping the reaction temperature at ice bath conditions. 3. the reaction mixture was stirred at ice bath temperature for 2 hours, followed by continued stirring at room temperature for 1 hour. 4. the reaction mixture was quenched by pouring into water (600 mL) containing excess sodium bisulfite. 5. The organic phase was separated and the aqueous phase was washed with additional dichloromethane (200 mL). 6. The organic extracts were combined, washed with saturated sodium bicarbonate solution and subsequently dried over anhydrous magnesium sulfate. 7. The solvent was removed by evaporation to afford the target product 2-fluoro-4-bromophenol as a colorless oil (34.5 g, 90% yield). 8. The structure of the product was confirmed to be as expected by NMR hydrogen spectroscopy (CDCl3).

References

[1] Patent: US4642338, 1987, A
[2] Patent: US4725683, 1988, A
[3] Patent: US4808750, 1989, A
[4] Patent: US4550192, 1985, A
[5] Chemistry - A European Journal, 2017, vol. 23, # 5, p. 1044 - 1047

4-Bromo-2-fluorophenol synthesis

Synthesis of 4-Bromo-2-fluorophenol from 2-Fluorophenol

4-Bromo-2-fluorophenol Preparation Products And Raw materials

Raw materials

2,4-Dibromo-6-fluorophenol Water Dichloromethane 2-Bromo-6-fluorophenol 2-Fluorophenol

Preparation Products

3-Fluoro-4-hydroxybenzoic acid Umbralisib 4-Ethoxy-3-fluorophenylboronic acid 3-Fluoro-2-methoxybenzaldehyde 4-(4-bromo-2-fluorophenoxy)tetrahydro-2H-pyran

4-Bromo-2-fluoro-6-iodo-phenol [1,1'-Biphenyl]-4,4'-diol, 3,3'-difluoro- 5-Bromo-1-fluoro-3-iodo-2-methoxy-benzene

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4-Bromo-2-fluorophenol Suppliers

Global Suppliers ( 454)

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	13396369453 18678026865	sdfantai@163.com	China	904	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60

Supplier	Advantage
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Beijing HwrkChemical Technology Co., Ltd	55
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60

View Latest Price from 4-Bromo-2-fluorophenol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	4-Bromo-2-fluorophenol 2105-94-4	$9.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-06-30	4-Bromo-2-fluorophenol 2105-94-4		1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-06-27	4-Bromo-2-fluorophenol 2105-94-4		1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd

4-Bromo-2-fluorophenol
2105-94-4
$9.00
99%
Henan Fengda Chemical Co., Ltd

4-Bromo-2-fluorophenol
2105-94-4
98.0%
Shaanxi Dideu New Materials Co. Ltd

4-Bromo-2-fluorophenol
2105-94-4
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Bromo-2-fluorophenol Spectrum

4-Bromo-2-fluorophenol(2105-94-4)MS 4-Bromo-2-fluorophenol(2105-94-4)¹HNMR 4-Bromo-2-fluorophenol(2105-94-4)¹³CNMR 4-Bromo-2-fluorophenol(2105-94-4)IR1

2105-94-4 (4-Bromo-2-fluorophenol) Related Search:

3-Fluorophenol 3-Trifluoromethylphenol 2-Bromophenol 4-Bromo-2-fluorobenzoic acid 4-Bromophenol

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4-Bromo-2,6-difluoroanisole 4-Bromo-2,5-difluoroanisole 4-Bromo-2-fluoro-6-nitrophenol 2,4-Dibromo-6-fluorophenol 2-(4'-Bromo-2'-fluorophenoxy)propane

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4-BROMO-2-FLUOROPHENOL 2-Fluoro-4-Bromophenol 4-Bromo-2-fluorophenol 98% 4-Bromo-2-fluorophenol98% 4-Bromo-2-fluorophenol, 97+% 4-Bromo-2-fluorophen 4-BroMo-2-fluorophenol, 98% 5GR 2-Fluoro-4-BroMophonel 4-Bromo-2-fluorophenol > 2-Fluor-4 bromophenol Phenol, 4-bromo-2-fluoro- 4-Bromo-2-fluorophenol ISO 9001：2015 REACH 4-Brom-2-Fluorphenol 2-Bromo-2-fluorophenol 2105-94-4 2105-94-9 2015-94-4 2195-94-4 BrC6H3FOH C6H4BrFO Building Blocks for Liquid Crystals Phenols (Building Blocks for Liquid Crystals) Building Blocks Organic Building Blocks Oxygen Compounds Phenols alcohol| alkyl bromide|alkyl Fluorine Building Blocks for Liquid Crystals Functional Materials Phenols (Building Blocks for Liquid Crystals) Organic Building Blocks Oxygen Compounds Fluorobenzene Phenol&Thiophenol&Mercaptan Bromine Compounds Fluorine Compounds Phenols Aromatic Phenols Fluorobenzene Series bc0001