2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid
- CAS No.
- 35480-52-5
- Chemical Name:
- 2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid
- Synonyms
- 5-Bis(2;Flecainide IMpurity D;Flecainide Impurity 1;Flecainide EP Impurity D;Flecainide Acetate IMpurity D;2,5-Di(2,2,2-Trifluoroethoxy)B;2-trifluoroethoxy)benzoic acid;Flecainide Acetate EP Impurity D;Flecainide acetate impurity D (EP);2,5-Bis(2,2,2-trifluoroethoxy)benzo
- CBNumber:
- CB6420736
- Molecular Formula:
- C11H8F6O4
- Molecular Weight:
- 318.17
- MDL Number:
- MFCD00221424
- MOL File:
- 35480-52-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 119-121°C |
|---|---|
| Boiling point | 320.9±42.0 °C(Predicted) |
| Density | 1.474±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| pka | 3.06±0.36(Predicted) |
| form | Solid |
| color | Off-white |
| InChI | InChI=1S/C11H8F6O4/c12-10(13,14)4-20-6-1-2-8(7(3-6)9(18)19)21-5-11(15,16)17/h1-3H,4-5H2,(H,18,19) |
| InChIKey | YPGYLCZBZKRYQJ-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC(OCC(F)(F)F)=CC=C1OCC(F)(F)F |
| CAS DataBase Reference | 35480-52-5(CAS DataBase Reference) |
| FDA UNII | ID4JP01L3W |
| UNSPSC Code | 12352106 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-36/37/39 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2918999090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B3227 | 2,5-Bis(2,2,2-trifluoroethoxy)benzoic Acid >98.0%(GC)(T) | 35480-52-5 | 5g | $23 | 2026-04-30 | Buy |
| TCI Chemical | B3227 | 2,5-Bis(2,2,2-trifluoroethoxy)benzoic Acid >98.0%(GC)(T) | 35480-52-5 | 25g | $45 | 2026-04-30 | Buy |
| TRC | TRC-B585485-25G | 2,5-Bis(2,2,2-trifluoroethoxy)benzoic Acid | 35480-52-5 | 25g | $318 | 2026-06-03 | Buy |
| TRC | TRC-B585485-10G | 2,5-Bis(2,2,2-trifluoroethoxy)benzoic Acid | 35480-52-5 | 10g | $196 | 2026-06-03 | Buy |
| TRC | TRC-B585485-100G | 2,5-Bis(2,2,2-trifluoroethoxy)benzoic Acid | 35480-52-5 | 100g | $1001 | 2026-06-03 | Buy |
2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Solid
Uses
Flecainide Acetate Impurity D.
Uses
2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid has been used in a variety of scientific research applications. It has been used as a reagent in the synthesis of organic compounds such as β-trifluoromethylbenzyl alcohols and β-trifluoromethylbenzyl chlorides. It has also been used as a catalyst in the synthesis of organic compounds such as α-trifluoromethylbenzyl alcohols and α-trifluoromethylbenzyl chlorides. Additionally, it has been used as a starting material in the synthesis of trifluoromethylated heterocyclic compounds such as thiazoles, oxazoles, and thiophenes.
Synthesis
75-89-8
21739-92-4
35480-52-5
Example 1: At room temperature, 300 mL of tetrahydrofuran (THF) was added to a reaction vial and 84.7 g of potassium tert-butanolate was added with stirring. Subsequently, 76.0 g of 2,2,2-trifluoroethanol was slowly added dropwise to the reaction mixture, controlling the reaction temperature to not exceed 35 °C. After the dropwise addition, the reaction mixture was continued to be stirred and then 29.6 g of 5-bromo-2-chlorobenzoic acid was added. Next, 27.3 g of copper (I) bromide was added and the reaction mixture was heated to reflux. After 43 hours of reaction, the mixture was cooled to 5 °C and slowly poured into dilute hydrochloric acid. The organic and aqueous phases were separated. The solvent was removed by distillation, during which the product gradually precipitated. 100 mL of water was added to the residue and the solid product was collected by filtration. To purify the product, the crude product was dissolved in methyl tertiary butyl ether (MTB ether), filtered through a neutral alumina column to remove insoluble components, and subsequently evaporated to remove the solvent. Finally, 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid was recrystallized by solvent recrystallization in ethanol/water mixture to give 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid in 45% yield. The product had a melting point of 120-122°C and was analyzed by high performance liquid chromatography (HPLC) with a purity greater than 98%.
References
[1] Patent: US2003/176721, 2003, A1
2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Neostar United (Changzhou) Industrial Co., Ltd. | 0519-85556579 13376258932 | project@neostarunited.com | China | 311 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451683 15021268886 | sales@arborchemical.com | China | 765 | 55 |
| Nanjing Hequan New Materials Technology Co., Ltd. | 18355039361 | 18355039361@163.com | China | 30 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Lastest Price from 2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-10 | Flecainide Impurity D
35480-52-5
|
$31.00-64.00 | 99.62% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-09-09 | 2,5-Bis(2,2,2-trifluoroethoxy)benzoic Acid
35480-52-5
|
$60.00 | 3kg | 99% | 5000 | Shanghai Yongzeng Technology Co.,Ltd | |
 |
2026-07-29 | Flecainide Impurity D
35480-52-5
|
$31.00-64.00 | 99.62% | 10g | TargetMol Chemicals Inc. |
-
- Flecainide Impurity D
35480-52-5
- $31.00-64.00
- 99.62%
- TargetMol Chemicals Inc.
-
- 2,5-Bis(2,2,2-trifluoroethoxy)benzoic Acid
35480-52-5
- $60.00
- 99%
- Shanghai Yongzeng Technology Co.,Ltd
-
- Flecainide Impurity D
35480-52-5
- $31.00-64.00
- 99.62%
- TargetMol Chemicals Inc.
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