FLECAINIDE ACETATE
- CAS No.
- 54143-56-5
- Chemical Name:
- FLECAINIDE ACETATE
- Synonyms
- FLAC;Apocard;Tambocor;r-818;Ecrinal;Almarytm;Flucarney Acetate;FLECAINIDE ACETATE;Flecainide-d4 Acetate;Flecainide acetate CRS
- CBNumber:
- CB9295801
- Molecular Formula:
- C19H24F6N2O5
- Molecular Weight:
- 474.39
- MDL Number:
- MFCD00214290
- MOL File:
- 54143-56-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 145-147℃ |
|---|---|
| storage temp. | 2-8°C |
| solubility | Soluble in water and in anhydrous ethanol. It is freely soluble in dilute acetic acid and practically insoluble in dilute hydrochloric acid. |
| form | Solid |
| color | White |
| Water Solubility | Soluble in dilute acetic acid, dimethyl sulfoxide, ethanol, methanol and water. |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month. |
| Major Application | pharmaceutical (small molecule) |
| InChIKey | RKXNZRPQSOPPRN-UHFFFAOYSA-N |
| SMILES | C1(C=C(C=CC=1OCC(F)(F)F)OCC(F)(F)F)C(=O)NCC1NCCCC1.C(=O)(O)C |
| EWG's Food Scores | 1 |
| FDA UNII | M8U465Q1WQ |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H319-H335-H360FD | |||||||||
| Precautionary statements | P201-P202-P301+P312-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38-63 | |||||||||
| Safety Statements | 22-26-36/37/39-45-46 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | - | |||||||||
| RTECS | CV5792550 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933399090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Repr. 1B Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
FLECAINIDE ACETATE price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001274 | Flecainide for system suitability European Pharmacopoeia (EP) Reference Standard | 54143-56-5 | 10 mg | $164 | 2026-04-30 | Buy |
| Sigma-Aldrich | F6777 | Flecainide acetate salt | 54143-56-5 | 25mg | $193 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR2921 | Flecainide Acetate pharmaceutical secondary standard, certified reference material | 54143-56-5 | 500MG | $241 | 2026-04-30 | Buy |
| Sigma-Aldrich | F0120000 | Flecainide acetate European Pharmacopoeia (EP) Reference Standard | 54143-56-5 | 10 mg | $164 | 2026-04-30 | Buy |
| Sigma-Aldrich | BP676 | Flecainide acetate British Pharmacopoeia (BP) Reference Standard | 54143-56-5 | 100MG | $287 | 2026-04-30 | Buy |
FLECAINIDE ACETATE Chemical Properties, Uses, Production
Description
Flecainide acetate (54143-56-5) is an open Na+channel blocker that inhibits fast Na+current in cardiac muscle in a use- and concentration-dependent manner.1Orally-active class Ic antiarrhythmic agent2,3. Inhibits hERG potassium channels at clinically relevant concentrations.4
Chemical Properties
White or almost white, very hygroscopic, crystalline powder.
Uses
Class I antiarrhythmic.
Uses
Flecainide acetate is used as a sodium channel blocker and as an anti-arrhythmic. In general, it is used to regulate heartbeats of the upper heart and lower heart chambers. It can also be used to slow down an overactive heart. It is also useful in the treatment of ventricular tachycardias and ventricular arrhythmias.
Definition
ChEBI: An acetate salt obtained by combining flecainide with one molar equivalent of acetic acid. An antiarrhythmic agent used to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).
brand name
Tambocor (3M Pharmaceuticals).
General Description
Flecainide acetate, N-(2-piperidinylmethyl)-2,5-bis (2,2,2-trifluoroethoxy)benzamide monoacetate(Tambocor), is a class IC antiarrhythmic drug withlocal anesthetic activity; it is a chemical derivative of benzamide.The drug undergoes biotransformation, forming ameta-O-dealkylated compound, whose antiarrhythmic propertiesare half as potent as those of the parent drug, and ameta-O-dealkylated lactam of flecainide with little pharmacologicalactivity. Flecainide acetate is given orally to suppresschronic ventricular ectopy and ventricular tachycardia.It has some limitations because of CNS side effects.
Biological Activity
Open Na + channel blocker that inhibits fast Na + current in cardiac muscle in a use- and concentration-dependent manner. Orally-active class Ic antiarrhythmic agent.
Biochem/physiol Actions
Class IC antiarrhythmic agent; sodium channel blocker
Drug interactions
Potentially hazardous interactions with other drugs Anti-arrhythmics: concentration increased by amiodarone - halve dose of flecainide; increased myocardial depression with other anti-arrhythmics. Antidepressants: concentration increased by fluoxetine; increased risk of ventricular arrhythmias with tricyclics. Antihistamines: increased risk of ventricular arrhythmias with mizolastine - avoid. Antihypertensives: increased myocardial depression and bradycardia with beta-blockers; increased myocardial depression and asystole with verapamil. Antimalarials: concentration increased by quinine; avoid with artemether/lumefantrine. Antimuscarinics: increased risk of ventricular arrhythmias with tolterodine. Antipsychotics: increased risk of ventricular arrhythmias with antipsychotics that prolong the QT interval and phenothiazines; increased risk of arrhythmias with clozapine. Antivirals: concentration possibly increased by fosamprenavir, indinavir, lopinavir, ritonavir and saquinavir, increased risk of ventricular arrhythmias - avoid; use telaprevir with caution. Diuretics: increased cardiac toxicity if hypokalaemia occurs.
Metabolism
Flecainide is extensively metabolised (subject to genetic polymorphism), the 2 major metabolites being m-Odealkylated flecainide and m-O-dealkylated lactam of flecainide, both of which may have some activity. Its metabolism appears to involve the cytochrome P450 isoenzyme CYP2D6, which shows genetic polymorphism.Flecainide is excreted mainly in the urine, approximately 30% as unchanged drug and the remainder as metabolites. About 5% is excreted in the faeces. Haemodialysis removes only about 1% of unchanged flecainide.
storage
Desiccate at +4°C
References
[1] R ROUET P D. Use- and concentration-dependent effects of flecainide in guinea pig right ventricular muscle.[J]. Journal of Cardiovascular Pharmacology, 1994, 24 2: 177-183.
[2] BRAMAH N. SINGH M.D. The Electrophysiology and Pharmacology of Verapamil, Flecainide, and Amiodarone: Correlations with Clinical Effects and Antiarrhythmic Actionsa[J]. Annals of the New York Academy of Sciences, 1984, 432 1: 210-235. DOI:10.1111/j.1749-6632.1984.tb14522.x
[3] E. H. BANITT. ANTIARRHYTHMICS. 2. SYNTHESIS AND ANTIARRHYTHMIC ACTIVITY OF N-(PIPERIDYLALKYL)TRIFLUOROETHOXYBENZAMIDES[J]. ChemInform, 1977, 38 1. DOI:10.1002/chin.197742198
[4] DARIO MELGARI . Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide[J]. Journal of molecular and cellular cardiology, 2015, 86: Pages 42-53. DOI:10.1016/j.yjmcc.2015.06.021
FLECAINIDE ACETATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9656 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8039 | 58 |
| Hubei XinyuanShun Chemical Co., Ltd. | 13971561712, 13995564702, 027-50664929 | hbeixys2001@163.com | China | 3110 | 55 |
View Latest Price from FLECAINIDE ACETATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Flecainide acetate
54143-56-5
|
$48.00-140.00 | 99.79% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-06-30 | FLECAINIDE ACETATE
54143-56-5
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-04-04 | Flecainide acetate
54143-56-5
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- Flecainide acetate
54143-56-5
- $48.00-140.00
- 99.79%
- TargetMol Chemicals Inc.
-
- FLECAINIDE ACETATE
54143-56-5
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- Flecainide acetate
54143-56-5
- 98%
- Henan Aochuang Chemical Co.,Ltd.
