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L-Citrulline

L-Citrulline Structure
L-Citrulline structure
CAS No.
372-75-8
Chemical Name:
L-Citrulline
Synonyms
CITRULLINE;(S)-2-AMINO-5-UREIDOPENTANOIC ACID;H-CIT-OH;L-CITRULINE;L-CIT;L-Cit-OH;Cit-OH;L-(+)-CITRULLINE;L-Citrullin;N5-(aminocarbonyl)-L-Ornithine
CBNumber:
CB6423883
Molecular Formula:
C6H13N3O3
Molecular Weight:
175.19
MDL Number:
MFCD00064397
MOL File:
372-75-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-23 17:48:05
Product description Number Pack Size Price
L-Citrulline pharmaceutical secondary standard, certified reference material PHR3191 500MG $233
L-Citrulline ≥98% (TLC) C7629 1kg $3270
L-Citrulline certified reference material, TraceCERT? 19936 10MG $73.5
L-Citrulline United States Pharmacopeia (USP) Reference Standard 1133842 200mg $535
L-Citrulline >98.0%(T) C0372 25g $27
More product size
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L-Citrulline Properties

Melting point 214 °C
alpha 25.5 º (c=8, 6N HCl)
Boiling point 306.48°C (rough estimate)
Density 1.2919 (rough estimate)
refractive index 26 ° (C=8, 6mol/L HCl)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Aqueous Acid (Sparingly). Water (Slightly)
form Crystals or Crystalline Powder
pka 2.43(at 25℃)
color White
Odor Odorless
optical activity +4.025 (H2O) +24.225 (1 mol dm-3 HCl)
Water Solubility 200 g/L (20 ºC)
Merck 14,2331
BRN 6055157
Major Application detection
Cosmetics Ingredients Functions SKIN CONDITIONING
InChI 1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1
InChIKey RHGKLRLOHDJJDR-BYPYZUCNSA-N
SMILES N[C@@H](CCCNC(N)=O)C(O)=O
LogP -3.190
CAS DataBase Reference 372-75-8(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 29VT07BGDA
NCI Drug Dictionary L-citrulline
EPA Substance Registry System L-Ornithine, N5-(aminocarbonyl)- (372-75-8)
UNSPSC Code 41116107
NACRES NA.32

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-36-26
WGK Germany  3
TSCA  TSCA listed
HS Code  29241900
Storage Class 11 - Combustible Solids
NFPA 704
1
0 0

L-Citrulline price More Price(95)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR3191 L-Citrulline pharmaceutical secondary standard, certified reference material 372-75-8 500MG $233 2026-04-30 Buy
Sigma-Aldrich C7629 L-Citrulline ≥98% (TLC) 372-75-8 1kg $3270 2026-04-30 Buy
Sigma-Aldrich 19936 L-Citrulline certified reference material, TraceCERT? 372-75-8 10MG $73.5 2026-04-30 Buy
Sigma-Aldrich 1133842 L-Citrulline United States Pharmacopeia (USP) Reference Standard 372-75-8 200mg $535 2026-04-30 Buy
TCI Chemical C0372 L-Citrulline >98.0%(T) 372-75-8 25g $27 2026-04-30 Buy
Product number Packaging Price Buy
PHR3191 500MG $233 Buy
C7629 1kg $3270 Buy
19936 10MG $73.5 Buy
1133842 200mg $535 Buy
C0372 25g $27 Buy

L-Citrulline Chemical Properties,Uses,Production

Chemical Properties

White powder

Originator

StaminO2,ErgoPharm

Uses

An amino acid, L-Citrulline can be used in the treatment of asthenia and as an essential intermediate in the biosynthesis of nitric oxide.

Uses

L-Citrulline, is used as an essential intermediate in the biosynthesis of nitric oxide from L-arginine . It is also used as a nutritional drink and biochemical reagent.

Definition

ChEBI: L-citrulline is the L-enantiomer of citrulline. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor, a protective agent, a nutraceutical, a micronutrient, a human metabolite, an Escherichia coli metabolite, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is an enantiomer of a D-citrulline. It is a tautomer of a L-citrulline zwitterion.

Manufacturing Process

Citrulline is obtained as a result of a reaction of L-arginine hydrochloride with sodium hydroxide, copper oxide and hydrogen sulfide.
In practice it is usually used as malate salt

Therapeutic Function

Stimulant, Detoxicant

benefits

L-citrulline is used for Alzheimer's disease, dementia, fatigue, muscle weakness, sickle cell disease, erectile dysfunction, high blood pressure, and diabetes. It is used for heart disease, body building, increasing energy, and for improving athletic performance.

Biochem/physiol Actions

L-Citrulline, when orally administered is found to ameliorate the condition of sickle cell disease in humans. L-citrulline can be a replacement for L-arginine administration in case of defective NO synthetase. L-Citrulline supplementation is found to fulfill the purpose of NO-dependent signaling.

target

NO | IL Receptor

Drug interactions

There are no reported side effects of L-citrulline.
However, the supplement may affect the way certain drugs work in your body. Do not take this supplement if you are taking:
Nitrates for heart disease
ED drugs such as sildenafil (Revatio, Viagra), tadalafil (Cialis), or vardenafil (Levitra, Staxyn)
Combining L-citrulline with those drugs may cause a dangerous drop in blood pressure.
You should also be careful when taking L-citrulline if you take any type of blood pressure medicine.
Do not use L-citrulline if you are pregnant or breastfeeding.

Purification Methods

Likely impurities are arginine and ornithine. Crystallise S-citrulline from water by adding 5 volumes of EtOH. Also crystallise it from water by addition of MeOH. [Ellenbogen J Am Chem Soc 74 5198 1952, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2491-2494 1961, Beilstein 4 IV 2647.]

References

[1] Patent: WO2009/25829, 2009, A1. Location in patent: Page/Page column 14-15
[2] Chemical communications (Cambridge, England), 2001, # 18, p. 1870 - 1871
[3] Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1931, vol. 203, p. 66
[4] Tohoku Journal of Experimental Medicine, 1941, vol. 41, p. 317
[5] Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1933, vol. 216, p. 244

L-Citrulline synthesis

74-79-3
372-75-8
Synthesis of L-Citrulline from L(+)-Arginine

L-Citrulline Preparation Products And Raw materials

Raw materials

Hydroxide L(+)-Arginine

Preparation Products

H-LYS(ALLOC)-OH MC-Val-Cit-PAB FMoc-Val-Cit-PAB FMoc-Val-Cit-PAB-PNP Mc-Val-Cit-PABC-PNP

L-Citrulline Suppliers

Global( 1034)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-17392712779 1097@dideu.com China 3989 58
RongNa Biotechnology Co.,Ltd 		+86-86-13583358881 +8618560316533 Brad@rongnabiotech.com China 3374 58
Wuhan Fortuna Chemical Co., Ltd 		+86-27-59207850 info@fortunachem.com China 5998 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 sales1@chuanghaibio.com China 5216 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		sarah@tnjone.com China 1139 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21533 55
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2984 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 sales@amoychem.com China 6339 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
RongNa Biotechnology Co.,Ltd 		58
Wuhan Fortuna Chemical Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Hefei TNJ Chemical Industry Co.,Ltd. 		55
career henan chemical co 		58
Xiamen AmoyChem Co., Ltd 		58

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Related Questions

Ask a question
Q:What are the benefits of L-citrulline? What are its side effects?Zora - Mar 24,2026
A:L-citrulline is naturally found in your body, in some foods and in supplements, it may help improve exercise performance, lower blood pressure, and manage blood sugar. Once ingested, the body converts L-citrulline into arginine in the kidneys. Afterward, arginine converts into nitric oxide, which dilates blood vessels and improves L-circulation. Excess it is eventually broken down by the liver. In studies, L-citrulline has been safely used in doses of 1.5-6 grams daily for up to two months. L-citrulline does not generally have many side effects. The most commonly reported side effects are stomach discomfort and heartburn.

View Lastest Price from L-Citrulline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-Citrulline pictures 2026-08-26 L-Citrulline
372-75-8
 $1.00 1kg 99% 10 tons RongNa Biotechnology Co.,Ltd
L-Citrulline pictures 2026-08-26 L-Citrulline
372-75-8
 1KG 98.5%-101%; AJI/USP 1000kg WUHAN FORTUNA CHEMICAL CO., LTD
L-Citrulline pictures 2026-08-12 L-Citrulline
372-75-8
 $17.50 100KG 98% 1-100mt Baoji Guokang Healthchem Co., Ltd.
  • L-Citrulline pictures
  • L-Citrulline
    372-75-8
  • $0.00
  • 98.5%-101%; AJI/USP
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • L-Citrulline pictures
  • L-Citrulline
    372-75-8
  • $17.50
  • 98%
  • Baoji Guokang Healthchem Co., Ltd.

L-Citrulline Spectrum

L-Citrulline(372-75-8)MSL-Citrulline(372-75-8)1HNMRL-Citrulline(372-75-8)13CNMRL-Citrulline(372-75-8)IR1L-Citrulline(372-75-8)IR2L-Citrulline(372-75-8)Raman

372-75-8(L-Citrulline)Related Search:

5-AMINOVALERIC ACID L-Tryptophan L(+)-Arginine Pivalic acid Semicarbazide
Estradiol valerate MAGNESIUM DIPROPYLACETATE HYDRATE 2-Propylpentanoic acid L-Serine L-Glutamine
L-Prolinamide L-Proline L-Methionine Glycine Aminoethoxyvinyl glycine hydrochloride
CITRULLINE-C13 L-Ornithine-2,3,3,4,4,5,5-d7, N5-(aminocarbonyl)- N-[(tert-Butoxy)carbonyl]-D-tryptophan

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Ibuprofen Impurity 78 Arginine Impurity 2（Arginine EP Impurity B）（Citrulline） L-CTRULLINE L-Citrullne Arginine EP Impurity B ALPHA-AMINO-DELTA-UREIDO-N-VALERIC ACID N-ORN(CARBAMOYL)-OH N-DELTA-CARBAMOYL-L-ORNITHINE L-CITRULLINERESEARCH GRADE L-Citrulline,(S)-2-Amino-5-ureidopentanoic acid, L-2-Amino-5-ureidovaleric acid L-Citrulline, extra pure L-2-AMINO-5-UREIDO-N-VALERIC ACID 2-Amino-5-(carbamoylamino)pentanoic acid a-Amino-D-ureidovaleric acid D-Carbamylornithine D-Ureidonorvaline (S)-2-Amino-5-ureidovaleric acid NSC 27425 Nδ-CarbaMylornithine α-AMino-δ-ureidovaleric Acid δ-Ureidonorvaline L-Citrulline-d7 L-CITRULLINE (5,5-D2, 98%) L-CITRULLINE (5-13C, 99% 4,4,5,5-D4, 95%) MICROBIOLOGICAL/PYROGEN TESTED 3,3,4-D3, 98%) L(+)-2-AMINO-5-UREIDOVALERIC ACID L-2-AMINO-5-UREIDOVALERIC ACID L-2-AMINE-5-UREIDOVAIERIC ACID L-2-AMINE-5-UREIDOVALERIC ACID L-CITRULLINE CITRULLINE, L- H-ORN(CONH2)-OH H-ORN(CARBAMOYL)-OH L-Citrulline (1.12117) L-Citrulline[(+)-2-amino-5-ureidopentanoic acid] L-CITRULLINE FOR BIOCHEMISTRY L-Citrulline,98% N5-CARBAMOYL-L-ORNITHINE L(+)-Citrulline, 99+% L-Citrulline(-ureido-13C) L-Ornithine, N5-(aminocarbonyl)- (2S)-2-amino-5-(carbamoylamino)pentanoic acid CITRULLINE, L-(RG) Citrulline Malate, L- (S)-2-Amino-5-ureidopentanoic acid L-2-Amino-5-ureidovaleric acid L-CITRULLINE extrapure CHR L-2-Amine-5-ureido-vaierieacid L-Citrulline≥ 99% (Assay) L-Orn(carbamoyl)-OH 2-Amino-5-ureidovalericacid citrulline,citrusextract L-citrullinate L-2-AMINO-5- L-Cflrulline L-Citrulline Standard L-Citrulline > L-Citrulline Reference Material