(4-Benzyl-1,4-oxazinan-2-yl)methanol
- CAS No.
- 40987-24-4
- Chemical Name:
- (4-Benzyl-1,4-oxazinan-2-yl)methanol
- Synonyms
- (4-BENZYLMORPHOLIN-2-YL)METHANOL;BUTTPARK 98\04-20;4-Benzyl-2-MorpholineMethanol;(4-Benzyl-2-morpholinyl)methanol;2-HYDROXYMETHYL-4-BENZYLMORPHOLINE;(4-Benzyl-1,4-oxazinan-2-yl)methanol;4-BENZYL-2-(HYDROXYMETHYL)MORPHOLINE;4-(PhenylMethyl)-2-MorpholineMethanol;2-Morpholinemethanol, 4-(phenylmethyl)-;4-Benzyl-2-(hydroxymethyl)morpholine, {[2-(Hydroxymethyl)morpholin-4-yl]methyl}benzene
- CBNumber:
- CB6436276
- Molecular Formula:
- C12H17NO2
- Molecular Weight:
- 207.27
- MDL Number:
- MFCD02682009
- MOL File:
- 40987-24-4.mol
- MSDS File:
- SDS
| Boiling point | 114°C 0,05mm |
|---|---|
| Density | 1.117±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Oil |
| pka | 14.36±0.10(Predicted) |
| color | Clear Pale Yellow |
| CAS DataBase Reference | 40987-24-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Hazard Codes | Xi |
| Risk Statements | 41 |
| Safety Statements | 24/25-39-26 |
| Hazard Note | Irritant |
| HS Code | 2934999090 |
(4-Benzyl-1,4-oxazinan-2-yl)methanol price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-H946450-50MG | 2-Hydroxymethyl-4-benzylmorpholine | 40987-24-4 | 50mg | $142 | 2026-06-03 | Buy |
| TRC | TRC-H946450-25MG | 2-Hydroxymethyl-4-benzylmorpholine | 40987-24-4 | 25mg | $84 | 2026-06-03 | Buy |
| TRC | TRC-H946450-100MG | 2-Hydroxymethyl-4-benzylmorpholine | 40987-24-4 | 100mg | $256 | 2026-06-03 | Buy |
| Apolloscientific | OR23185 | (4-Benzylmorpholin-2-yl)methanol 95% | 40987-24-4 | 250mg | $21 | 2026-06-04 | Buy |
| Activate Scientific | AS24189 | 4-Benzyl-2-(hydroxymethyl)morpholine 97% | 40987-24-4 | 1g | $43 | 2026-06-04 | Buy |
(4-Benzyl-1,4-oxazinan-2-yl)methanol Chemical Properties, Uses, Production
Chemical Properties
Green Oil
Uses
Intermediate in the preparation of various antidepressants and protein kinase inhibitors.
Synthesis
40987-25-5
40987-24-4
Step 3b: Synthesis of (4-benzylmorpholin-2-yl)methanol 20.3 g of 4-benzyl-2-chloromethylmorpholine, 3.5 mL of water and 45 mL of formamide (CAS: 75-12-7) were added to a 250 mL round-bottom flask in a unit equipped with a condenser tube and a thermometer under argon protection. The reaction mixture was heated to 215 °C and reacted under formamide reflux conditions for 3 h, followed by cooling to 50 °C using an ice water bath. An additional 3.5 mL of water was added and the reaction was continued at reflux for 2 hours. After the reaction solution was cooled to room temperature (20 °C), it was poured into 150 mL of ice water and the pH was adjusted to 12 with 50 mL of 10 M sodium hydroxide solution for two extractions. The organic phases were combined, washed with 50 mL of saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and subsequently dried under vacuum at 3 mbar for 1 hour. A final 13.4 g of (4-benzylmorpholin-2-yl) methanol was obtained as an amber colored oil (72% yield).
References
[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 6, p. 2227 - 2244
[2] Patent: US2013/274253, 2013, A1. Location in patent: Paragraph 1825-1826
[3] Synthetic Communications, 1980, vol. 10, # 1, p. 59 - 74
(4-Benzyl-1,4-oxazinan-2-yl)methanol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Songfan Pharmaceutical Technology Co., Ltd. | 17321241880 | 485229790@qq.com | China | 1747 | 58 |
| Nanbu County Chengxin Technology Co., Ltd. | 0838-5675166 15883665058 | nbcxkj@126.com | China | 956 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| ForeChem (Nantong) Technology Co.,Ltd. | 513-85982855 18921614129 | sales@xianxingpharm.com | China | 2712 | 61 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Boc Chemical Co.,Ltd | 021-34975603-808 18721111801 | sales@bocpharma.com | China | 991 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
View Latest Price from (4-Benzyl-1,4-oxazinan-2-yl)methanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | (4-BENZYL-1,4-OXAZINAN-2-YL)METHANOL
40987-24-4
|
$8.00 | 1kg | 99% | 10tons | Career Henan Chemical Co | |
 |
2019-07-06 | (4-BENZYL-1,4-OXAZINAN-2-YL)METHANOL
40987-24-4
|
$1.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- (4-BENZYL-1,4-OXAZINAN-2-YL)METHANOL
40987-24-4
- $8.00
- 99%
- Career Henan Chemical Co
-
- (4-BENZYL-1,4-OXAZINAN-2-YL)METHANOL
40987-24-4
- $1.00
- 98%
- Career Henan Chemical Co
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