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4-Bromo-3-methoxyaniline

4-Bromo-3-methoxyaniline Structure
4-Bromo-3-methoxyaniline structure
CAS No.
19056-40-7
Chemical Name:
4-Bromo-3-methoxyaniline
Synonyms
4-methoxy-3-bromo aniline;4-BROMO-3-METHOXY-PHENYLAMINE;4-Bromo-m-anisidine;5-Amino-2-bromoanisole;-BROMO-3-METHOXYANILINE;3-methoxy-4-bromoaniline;4-Bromo-3-methoxyaniline;4-Bromo-3-methoxyaniline 98%;4-Bromo-3-methoxybenzenamine;BenzenaMine,4-broMo-3-Methoxy-
CBNumber:
CB6465920
Molecular Formula:
C7H8BrNO
Molecular Weight:
202.05
MDL Number:
MFCD05664063
MOL File:
19056-40-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:54:16
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4-Bromo-3-methoxyaniline Properties

Melting point 96-100 °C(lit.)
Boiling point 272.1±20.0 °C(Predicted)
Density 1.531±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 3.47±0.10(Predicted)
form solid
color Beige
BRN 2690835
InChI InChI=1S/C7H8BrNO/c1-10-7-4-5(9)2-3-6(7)8/h2-4H,9H2,1H3
InChIKey RUTNWXBHRAIQSP-UHFFFAOYSA-N
SMILES C1(N)=CC=C(Br)C(OC)=C1
CAS DataBase Reference 19056-40-7(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Exclamation Mark (GHS07)
GHS06,GHS07
Signal word  Warning
Hazard statements  H312-H315-H319-H331-H335-H302-H317
Precautionary statements  P261-P304+P340-P305+P351+P338-P405-P501a-P280
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  22-43
Safety Statements  36/37
RIDADR  UN2811
WGK Germany  2
Hazard Note  Irritant
HazardClass  6.1
PackingGroup  III
HS Code  29222990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Skin Sens. 1
NFPA 704
1
2 0

4-Bromo-3-methoxyaniline price More Price(70)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical B3240 4-Bromo-3-methoxyaniline min. 98.0 % 19056-40-7 5G $124 2026-04-30 Buy
TCI Chemical B3240 4-Bromo-3-methoxyaniline min. 98.0 % 19056-40-7 25G $372 2026-04-30 Buy
Usbiological 261890 4-Bromo-3-methoxyaniline Asreported 19056-40-7 2g $366 2026-06-03 Buy
Usbiological 261890 4-Bromo-3-methoxyaniline Asreported 19056-40-7 5g $579 2026-06-03 Buy
Usbiological 261890 4-Bromo-3-methoxyaniline Asreported 19056-40-7 10g $835 2026-06-03 Buy
Product number Packaging Price Buy
B3240 5G $124 Buy
B3240 25G $372 Buy
261890 2g $366 Buy
261890 5g $579 Buy
261890 10g $835 Buy

4-Bromo-3-methoxyaniline Chemical Properties, Uses, Production

Chemical Properties

White to brown crystalline powder

Uses

4-Bromo-3-(methyloxy)aniline is a useful reagent for organic synthesis and other chemical processes. It is used in the preparation of 4-Anilino substituted α-carboline compounds as active Brk inhibitors (breast tumor kinase) which are interesting targets for cancer therapy.

Synthesis

2-BROMO-5-NITROANISOLE

77337-82-7

4-BROMO-3-METHOXYANILINE

19056-40-7

General procedure for the synthesis of 4-bromo-3-methoxyaniline from 2-bromo-5-nitroanisole: To a solution of 1-bromo-2-methoxy-4-nitrobenzene (23 g, 99.6 mmol) in tetrahydrofuran (THF, 200 mL) was added ammonium chloride (64 g, 1.2 mol) and zinc powder (78.1 g, 1.2 mol). The reaction mixture was heated to reflux overnight. After completion of the reaction, the mixture was cooled to room temperature, filtered through a bed of diatomite (Celite) and the filtrate was concentrated under reduced pressure. The concentrated residue was partitioned between water (200 mL) and ethyl acetate (200 mL). The organic layer was separated, washed with brine solution (100 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 4-bromo-3-methoxyaniline (17.4 g, 87% yield) as a yellow solid. The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, DMSO-d6, 400 MHz): δ 7.1 (d, 1H), 6.31 (s, 1H), 6.1 (d, 1H), 5.27 (bs, 2H), 3.72 (s, 3H) ppm.

References

[1] Patent: US4882354, 1989, A
[2] Patent: WO2015/6100, 2015, A1. Location in patent: Page/Page column 194
[3] Chemical and Pharmaceutical Bulletin, 2014, vol. 62, # 10, p. 979 - 988
[4] Patent: WO2007/37187, 2007, A1. Location in patent: Page/Page column 127
[5] Tetrahedron Letters, 1995, vol. 36, # 42, p. 7583 - 7586

4-Bromo-3-methoxyaniline synthesis

77337-82-7
19056-40-7
Synthesis of 4-Bromo-3-methoxyaniline from 2-Bromo-5-nitroanisole

4-Bromo-3-methoxyaniline Preparation Products And Raw materials

Raw materials

m-Anisidine 2-Bromo-5-nitroanisole ZINC Tetrahydrofuran Ammonium chloride

Preparation Products

1-(4-BroMo-3-Methoxyphenyl)ethanone 2-Bromo-5-iodoanisole 2,5-Dibromoanisole 4-Bromo-3-methoxybenzonitrile 2-(4-Bromo-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

4-Bromo-3-methoxyaniline Suppliers

Global Suppliers ( 246)
Supplier Tel Email Country ProdList Advantage
Nanjing Tangzheng Biomedical Technology Co., Ltd 13016839191 719086845@qq.com China 101 58
Shanghai Fengluan Biotechnology Co., LTD 13357659136 jing.z@fengluanbiotech.com China 497 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Changzhou Huanling Chemical Co., Ltd. 89803005 18206112582 info@huanlingchem.com China 983 68
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Supplier Advantage
Nanjing Tangzheng Biomedical Technology Co., Ltd 58
Shanghai Fengluan Biotechnology Co., LTD 58
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Changzhou Huanling Chemical Co., Ltd. 68
Jia Xing Isenchem Co.,Ltd 66
Accela ChemBio Co.,Ltd. 64

View Latest Price from 4-Bromo-3-methoxyaniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-BROMO-3-METHOXYANILINE pictures 2026-08-20 4-BROMO-3-METHOXYANILINE
19056-40-7
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
4-BROMO-3-METHOXYANILINE pictures 2021-07-02 4-BROMO-3-METHOXYANILINE
19056-40-7
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
4-BROMO-3-METHOXYANILINE pictures 2019-07-06 4-BROMO-3-METHOXYANILINE
19056-40-7
 $8.80 1KG 97%-99% 100kg Career Henan Chemical Co

4-Bromo-3-methoxyaniline Spectrum

4-BROMO-3-METHOXYANILINE(19056-40-7)1HNMR4-BROMO-3-METHOXYANILINE(19056-40-7)FT-IR

19056-40-7 (4-Bromo-3-methoxyaniline) Related Search:

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4-Bromo-m-anisidine 5-Amino-2-bromoanisole 4-BROMO-3-METHOXYANILINE, 98+% 4-Bromo-3-methoxyaniline 98% 2-bromo-5-aminoanisole(4-bromo-3-methoxyaniline) 4-Bromo-3-methoxyaniline, 97+% 2-AMino-5-broMo-6-Methoxypyridine 5-Amino-2-bromoanisole, 4-Bromo-m-anisidine 5-AMino-2-broMoanisole[4-BroMo-3-Methoxyaniline] BenzenaMine,4-broMo-3-Methoxy- 4-BROMO-3-METHOXYANILINE ISO 9001：2015 REACH 3-methoxy-4-bromoaniline 4-Bromo-3-methoxybenzenamine -BROMO-3-METHOXYANILINE 4-BROMO-3-METHOXY-PHENYLAMINE 4-methoxy-3-bromo aniline 4-Bromo-3-methoxyaniline 19056-40-7 9056-40-7 BrC6H3OCH3NH2 C7 Amines Building Blocks Organic Building Blocks Nitrogen Compounds amine| alkyl bromide Amines C7 Nitrogen Compounds Anisoles, Alkyloxy Compounds & Phenylacetates Bromine Compounds Anilines, Aromatic Amines and Nitro Compounds Benzene series Anilines, Amides & Amines