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6-Aminothiouracil

6-Aminothiouracil structure

CAS No.: 1004-40-6

Chemical Name:: 6-Aminothiouracil

Synonyms: AB 48;NSC 1587;NSC 202018;NSC 321193;NSC 321194;AURORA 13795;6-Aminothiouracil;4-Amino-2-thiouracil;6-AMINO-2-THIOURACIL;6-amino-2-thio-uraci

CBNumber:: CB6730983

Molecular Formula:: C4H5N3OS

Molecular Weight:: 143.17

MDL Number:: MFCD00052384

MOL File:: 1004-40-6.mol

MSDS File:: SDS

Last updated:2025-12-31 14:38:37

Product description	Number	Pack Size	Price
4-Amino-6-hydroxy-2-mercaptopyrimidine	A0791	25G	$29
6-Amino-4-hydroxy-2-mercaptopyrimidine	FA11937	100g	$139
6-Amino-4-hydroxy-2-mercaptopyrimidine	FA11937	25g	$60
4-Amino-6-hydroxy-2-mercaptopyrimidine	7175AF	1g	$63
4-Amino-6-hydroxy-2-mercaptopyrimidine monohydrate	3276AH	1g	$63
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6-Aminothiouracil Properties

Melting point	>300C (dec.)
Boiling point	246.5°C
Density	1.397 (estimate)
refractive index	1.7490 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	7.92±0.20(Predicted)
form	crystalline solid
color	Off-white
Water Solubility	256.3mg/L(25 ºC)
InChI	InChI=1S/C4H5N3OS/c5-2-1-3(8)7-4(9)6-2/h1H,(H4,5,6,7,8,9)
InChIKey	YFYYRKDBDBILSD-UHFFFAOYSA-N
SMILES	C1(=S)NC(N)=CC(=O)N1
CAS DataBase Reference	1004-40-6(CAS DataBase Reference)
NIST Chemistry Reference	Uracil, 6-amino-2-thio-(1004-40-6)
EPA Substance Registry System	6-Amino-2-thiouracil (1004-40-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P271-P261-P280
Hazard Codes	Xi
RTECS	UW0495000
TSCA	TSCA listed
HS Code	2933599590
Toxicity	LD50 ipr-mus: 370 mg/kg ARZNAD 31,1713,81

6-Aminothiouracil price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	A0791	4-Amino-6-hydroxy-2-mercaptopyrimidine	1004-40-6	25G	$29	2025-07-31	Buy
Biosynth Carbosynth	FA11937	6-Amino-4-hydroxy-2-mercaptopyrimidine	1004-40-6	100g	$139	2021-12-16	Buy
Biosynth Carbosynth	FA11937	6-Amino-4-hydroxy-2-mercaptopyrimidine	1004-40-6	25g	$60	2021-12-16	Buy
AK Scientific	7175AF	4-Amino-6-hydroxy-2-mercaptopyrimidine	1004-40-6	1g	$63	2021-12-16	Buy
AK Scientific	3276AH	4-Amino-6-hydroxy-2-mercaptopyrimidine monohydrate	1004-40-6	1g	$63	2021-12-16	Buy

Product number	Packaging	Price	Buy
A0791	25G	$29	Buy
FA11937	100g	$139	Buy
FA11937	25g	$60	Buy
7175AF	1g	$63	Buy
3276AH	1g	$63	Buy

6-Aminothiouracil Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

LAbelled derivative of 6-Amino-2-thiouracil as novel, potent, and selective A3 adenosine receptor antagonists.

Safety Profile

Poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofNOx and SOx.

Synthesis

17356-08-0

105-56-6

1004-40-6

General procedure for the synthesis of 6-amino-2-thiouracil from the compound (CAS: 17356-08-0) and ethyl cyanoacetate: 101.5 g (1.88 mol) of sodium methanol was accurately weighed in a reaction flask containing 3 L of 670 g ethanol at room temperature. Subsequently, 67.3 g (0.88 mol) of thiourea was added and stirred until complete dissolution. The reaction mixture was heated to 55 °C and then 100 g (0.884 mol) of ethyl cyanoacetate was slowly added. The heating was continued to reflux and the reflux reaction was maintained for 4.5 h. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction solution was cooled to 15 °C. The reaction mixture was filtered and the filter cake was washed once with 170 g ethanol. The washed filter cake was transferred to a 3 L reaction flask and appropriate amount of water was added, followed by 1.3 kg of water and stirred until complete dissolution. The pH of the solution was adjusted to 4 by slowly adding acetic acid at 20 °C, at which point a large amount of solid precipitated. The solid product was collected by filtration using a suction filter. The filter cake was dried at 45 °C overnight to give a final product of 115.4 g of 6-amino-2-thiouracil in 91.7% yield.

References

[1] Patent: CN106008633, 2016, A. Location in patent: Paragraph 0065; 0066; 0067; 0068
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 7, p. 662 - 668
[3] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 13, p. 4612 - 4621
[4] Organic and Biomolecular Chemistry, 2018, vol. 16, # 18, p. 3389 - 3395
[5] Australian Journal of Chemistry, 2007, vol. 60, # 2, p. 120 - 123

6-Aminothiouracil Preparation Products And Raw materials

Raw materials

Ethanol Sodium Ethyl cyanoacetate Thiourea Carbamimidothioic acid

Sodium Methoxide

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Preparation Products

4,5-Diamino-6-hydroxypyrimidine 6-Mercaptopurine 6-Hydroxypurine 6-AMINO-5-BROMO-2-(ETHYLTHIO)PYRIMIDIN-4-OL 2-MERCAPTO-5,7-DIMETHYL-PYRIDO[2,3-D]PYRIMIDIN-4-OL

2-(BENZYLMERCAPTO)-4-HYDROXY-6-AMINOPYRIMIDINE

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6-Aminothiouracil Suppliers

Global( 206)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-173 9270 1263	1057@dideu.com	China	3998	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58

Supplier	Advantage
Frapp's ChemicalNFTZ Co., Ltd.	50
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
HaBo Hong Kong Co., Limited.	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Antai Fine Chemical Technology Co.,Limited	58

View Lastest Price from 6-Aminothiouracil manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-05-15	6-Aminothiouracil 1004-40-6	US $1.00 / KG	1KG	99%	20T	Shaanxi Dideu Medichem Co. Ltd
	2019-07-12	6-Aminothiouracil 1004-40-6	US $1.00 / KG	1KG	99%	25kg	Career Henan Chemical Co

6-Aminothiouracil
1004-40-6
US $1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

6-Aminothiouracil
1004-40-6
US $1.00 / KG
99%
Career Henan Chemical Co

6-Aminothiouracil Spectrum

6-Aminothiouracil(1004-40-6)MS 6-Aminothiouracil(1004-40-6)¹HNMR 6-Aminothiouracil(1004-40-6)¹³CNMR 6-Aminothiouracil(1004-40-6)IR1 6-Aminothiouracil(1004-40-6)IR2

1004-40-6(6-Aminothiouracil)Related Search:

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6-Mercaptopurine Calcium thioglycolate Acetaminophen Thioglycolic acid Diethylaminosulfur trifluoride

6-Aminocaproic acid 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL 1-PHENYL-2-THIOUREA POTASSIUM THIOGLYCOLATE 4-Hydroxy-6-aminopyrimidine

2-Aminophenol Tris(hydroxymethyl)aminomethane Glycine

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4-Amino-2-thiouracil 4-AMINO-6-HYDROXY-2-MERCAPTOPYRIMIDINE AURORA 13795 OTAVA-BB BB7013910011 6-AMINO-2-THIOXO-2,3-DIHYDRO-1H-PYRIMIDIN-4-ONE 6-AMINO-2-THIOXO-2,3-DIHYDROPYRIMIDIN-4(1H)-ONE 6-Aminothiouracil 6-amino-2,3-dihydro-2-thioxo-4(1h)-pyrimidinone 2-Mercapto-6-aminouracil 2-MERCAPTO-4-HYDROXY-6-AMINO-PYRIMIDINE 6-AMINO-4-KETO-2-THIOPYRIMIDINE 6-Amino-2-sulfanylidene-1H-pyrimidin-4-one 6-AMINO-2-THIOURACIL 4(1H)-Pyrimidinone, 6-amino-2,3-dihydro-2-thioxo- (9CI) 4-Amino-2-mercaptouracil NSC 1587 NSC 202018 NSC 321193 NSC 321194 6-Amino-2,3-dihydro-2-thioxopyrimidin-4(1H)-one 97% 6-Amino-2-thiouracil, 4-Amino-6-hydroxypyrimidine-2-thiol 6-Amino-2,3-dihydro-2-thioxo-1H-pyrimidin-4-one 6-Amino-2,3-dihydro-2-thioxopyrimidin-4(1H)-one 4(1H)-Pyrimidinone, 6-amino-2,3-dihydro-2-thioxo- 6-amino-2,3-dihydro-2-thioxo-4(1h)-pyrimidinon 6-amino-2-thio-uraci 6-Amino-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone AB 48 Pyrimidin-4-ol, 6-amino-2-mercapto- 6-Amino-2-mercapto-pyrimidin-4-ol ,97% 2-Thioxo-6-amino-1,2-dihydropyrimidine-4(3H)-one 6-Amino-2-mercaptopyrimidin-4(1H)-one 6-Amino-2-thioxo-1,2-dihydropyrimidine-4(3H)-one 4-Amino-2-thiouracil Discontinued See: A630455 4-amino-6-hydroxy-2-thiopyrimidine 6-Amino-2-mercapto-pyrimidin-4-ol ,98% 2-thio-6-aminouracil 1004-40-6 C4H5N3OS Heterocycle-Pyrimidine series Chemical Amines Bases & Related Reagents Heterocycles Nucleotides Sulfur & Selenium Compounds Imidazoles & Benzimidazoles Pyrazines, Pyrimidines & Pyridazines PYRIMIDINE Pyridines, Pyrimidines, Purines and Pteredines Amines Pyrazines, Pyrimidines & Pyridazines Imidazoles & Benzimidazoles