6-Aminothiouracil
- CAS No.
- 1004-40-6
- Chemical Name:
- 6-Aminothiouracil
- Synonyms
- 4-AMINO-6-HYDROXY-2-MERCAPTOPYRIMIDINE;AB 48;NSC 1587;NSC 202018;NSC 321193;NSC 321194;AURORA 13795;6-Aminothiouracil;4-Amino-2-thiouracil;6-AMINO-2-THIOURACIL
- CBNumber:
- CB6730983
- Molecular Formula:
- C4H5N3OS
- Molecular Weight:
- 143.17
- MDL Number:
- MFCD00052384
- MOL File:
- 1004-40-6.mol
- MSDS File:
- SDS
| Melting point | >300C (dec.) |
|---|---|
| Boiling point | 246.5°C |
| Density | 1.397 (estimate) |
| refractive index | 1.7490 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | crystalline solid |
| pka | 7.92±0.20(Predicted) |
| color | Off-white |
| Water Solubility | 256.3mg/L(25 ºC) |
| InChI | InChI=1S/C4H5N3OS/c5-2-1-3(8)7-4(9)6-2/h1H,(H4,5,6,7,8,9) |
| InChIKey | YFYYRKDBDBILSD-UHFFFAOYSA-N |
| SMILES | C1(=S)NC(N)=CC(=O)N1 |
| CAS DataBase Reference | 1004-40-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Uracil, 6-amino-2-thio-(1004-40-6) |
| EPA Substance Registry System | 6-Amino-2-thiouracil (1004-40-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P271-P261-P280 |
| Hazard Codes | Xi |
| RTECS | UW0495000 |
| TSCA | TSCA listed |
| HS Code | 2933599590 |
| Toxicity | LD50 ipr-mus: 370 mg/kg ARZNAD 31,1713,81 |
6-Aminothiouracil price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A0791 | 4-Amino-6-hydroxy-2-mercaptopyrimidine | 1004-40-6 | 25G | $26 | 2026-04-30 | Buy |
| Apolloscientific | OR6128 | 6-Amino-2-thiouracil 98% | 1004-40-6 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR6128 | 6-Amino-2-thiouracil 98% | 1004-40-6 | 25g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR6128 | 6-Amino-2-thiouracil 98% | 1004-40-6 | 100g | $48 | 2026-06-04 | Buy |
| Apolloscientific | OR6128 | 6-Amino-2-thiouracil 98% | 1004-40-6 | 500g | $230 | 2026-06-04 | Buy |
6-Aminothiouracil Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
LAbelled derivative of 6-Amino-2-thiouracil as novel, potent, and selective A3 adenosine receptor antagonists.
Safety Profile
Poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofNOx and SOx.
Synthesis
17356-08-0
105-56-6
1004-40-6
General procedure for the synthesis of 6-amino-2-thiouracil from the compound (CAS: 17356-08-0) and ethyl cyanoacetate: 101.5 g (1.88 mol) of sodium methanol was accurately weighed in a reaction flask containing 3 L of 670 g ethanol at room temperature. Subsequently, 67.3 g (0.88 mol) of thiourea was added and stirred until complete dissolution. The reaction mixture was heated to 55 °C and then 100 g (0.884 mol) of ethyl cyanoacetate was slowly added. The heating was continued to reflux and the reflux reaction was maintained for 4.5 h. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction solution was cooled to 15 °C. The reaction mixture was filtered and the filter cake was washed once with 170 g ethanol. The washed filter cake was transferred to a 3 L reaction flask and appropriate amount of water was added, followed by 1.3 kg of water and stirred until complete dissolution. The pH of the solution was adjusted to 4 by slowly adding acetic acid at 20 °C, at which point a large amount of solid precipitated. The solid product was collected by filtration using a suction filter. The filter cake was dried at 45 °C overnight to give a final product of 115.4 g of 6-amino-2-thiouracil in 91.7% yield.
References
[1] Patent: CN106008633, 2016, A. Location in patent: Paragraph 0065; 0066; 0067; 0068
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 7, p. 662 - 668
[3] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 13, p. 4612 - 4621
[4] Organic and Biomolecular Chemistry, 2018, vol. 16, # 18, p. 3389 - 3395
[5] Australian Journal of Chemistry, 2007, vol. 60, # 2, p. 120 - 123
6-Aminothiouracil Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Habo Medical Technology Co., Ltd. | 13376080562 13376090521 | sales@habotech.com | China | 726 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Lastest Price from 6-Aminothiouracil manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-05-15 | 6-Aminothiouracil
1004-40-6
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-12 | 6-Aminothiouracil
1004-40-6
|
$1.00 | 1KG | 99% | 25kg | Career Henan Chemical Co |
-
- 6-Aminothiouracil
1004-40-6
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 6-Aminothiouracil
1004-40-6
- $1.00
- 99%
- Career Henan Chemical Co
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