Skyrin
- CAS No.
- 602-06-2
- Chemical Name:
- Skyrin
- Synonyms
- skyrin;Skirin;Endothianin;Rhodophyscin;3',8''-BIAPIGENIN;I3,II8 BIAPIGENIN;DIDEMETHYL-GINKGETIN;4',4''',5,5'',7,7''-HEXAHYDROXY-3''',8-BIFLAVONE;(+)-2,2',4,4',5,5'-Hexahydroxy-7,7'-dimethyl-1,1'-bianthraquinone;2,4,5,2',4',5'-hexahydroxy-7,7'-dimethyl-[1,1']bianthryl-9,10,9',10'-tetraone
- CBNumber:
- CB6744025
- Molecular Formula:
- C30H18O10
- Molecular Weight:
- 538.46
- MDL Number:
- MFCD00597057
- MOL File:
- 602-06-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >380℃ |
|---|---|
| Boiling point | 956.1±65.0 °C(Predicted) |
| Density | 1.698±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble |
| pka | 5.24±0.20(Predicted) |
| form | A crystalline solid |
| color | Orange to dark red |
| biological source | Penicillium islandicum |
| InChI | 1S/C30H18O10/c1-9-3-11-19(13(31)5-9)29(39)23-17(35)7-15(33)21(25(23)27(11)37)22-16(34)8-18(36)24-26(22)28(38)12-4-10(2)6-14(32)20(12)30(24)40/h3-8,31-36H,1-2H3 |
| InChIKey | MQSXZQXHIJMNAF-UHFFFAOYSA-N |
| SMILES | Oc1c2c(c(c(c1)O)c4c5c(c(cc4O)O)C(=O)c6c(cc(cc6O)C)C5=O)C(=O)c3c(c(cc(c3)C)O)C2=O |
| FDA UNII | VLA1F42GXP |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
Skyrin price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0459 | Skyrin ≥98% (HPLC) | 602-06-2 | 1mg | $272 | 2026-04-30 | Buy |
| Cayman Chemical | 13102 | Skyrin ≥97% | 602-06-2 | 1mg | $280 | 2026-04-30 | Buy |
| Usbiological | S1013-94 | Skyrin, Talaromyces sp. (Rhodophyscin, Endothianin) ≥97%(HPLC) | 602-06-2 | 1mg | $502 | 2026-06-04 | Buy |
| Biosynth | AAA60206 | Skyrin | 602-06-2 | 5mg | $1780.7 | 2026-06-04 | Buy |
| Biosynth | AAA60206 | Skyrin | 602-06-2 | 10mg | $2849.1 | 2026-06-04 | Buy |
Skyrin Chemical Properties, Uses, Production
Uses
Skyrin is a non-peptidic anthraquinone, mycotoxin.
Definition
ChEBI: Skyrin is a biaryl and a trihydroxyanthraquinone. It is functionally related to an emodin.
Biological Activity
Skyrin is a non-peptidic anthraquinone, mycotoxin with in vitro cytotoxic activity. It suppresses the growth of HeLa, Vero, K562, Raji, Wish and Calu-1 cell lines. Skyrin treatment induces DNA fragmentation and other morphological changes leading to apoptosis in Human HL-60 promyelotic leukemia cells. Skyrin was found to serve as an anti-diabetic agent by selectively binding to the glucagon receptor acting as its antagonist. Regular binding of glucagon to its receptor on hepathocyte plasma membrane activates adenylate cyclase indirectly. As a result, the cAMP produced activates protein kinase A with a consequent increase in both glycogen breakdown and gluconeogenesis leading to glucose output. Skyrin was shown to block this signal transduction sequence, such th at the interaction of glucagons with its receptor does not result in an increase in cAMP production. Skyrin was also found to efficiently scavenge free radical species as OH, R and of singlet oxygen (1O2). Based on Skyrin selective toxicity towards insect cell line Sf9, it may be useful as an agent for pest control.
storage
+4°C
Skyrin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
| Vientiane Tianjin Hengyuan Technology Co., Ltd. | 15722085254 | phytochemical@126.com | China | 813 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4578 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4372 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3969 | 58 |
| Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 | sales@mitachieve.com | China | 8857 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
