Catalpol | 2415-24-9

Catalpol Properties

Melting point	203-205°C
Boiling point	675.6±55.0 °C(Predicted)
Density	1.72±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
pka	12.79±0.70(Predicted)
form	Solid
color	White to Off-White
InChI	InChI=1/C15H22O10/c16-3-6-9(19)10(20)11(21)14(23-6)24-13-7-5(1-2-22-13)8(18)12-15(7,4-17)25-12/h1-2,5-14,16-21H,3-4H2/t5-,6-,7-,8+,9-,10+,11-,12+,13+,14+,15-/s3
InChIKey	LHDWRKICQLTVDL-CLLMHHLUSA-N
SMILES	C([C@]12O[C@H]1[C@@H](O)[C@]1([H])C=CO[C@@H](O[C@@]3([H])[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)[C@]21[H])O \|&1:1,3,4,6,11,13,15,16,18,20,25,r\|
LogP	-4.609 (est)
FDA UNII	JCX5L7JIC2
UNSPSC Code	41116107
NACRES	NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

Hazard Codes

Xi

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

3

RTECS

LZ5776816

HS Code

29389090

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Toxicity

mouse,LD,intravenous,> 2500mg/kg (2500mg/kg),Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64, Pg. 93, 1968.

NFPA 704

	0
2		0

Catalpol price More Price(71)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHL89595	Catalpol phyproof? Reference Substance	2415-24-9	10MG	$570	2026-04-30	Buy
Sigma-Aldrich	50839	Catalpol ≥96% (HPLC)	2415-24-9	25mg	$348	2026-04-30	Buy
TCI Chemical	C3494	Catalpol	2415-24-9	250MG	$196	2026-04-30	Buy
Cayman Chemical	24925	Catalpol ≥98%	2415-24-9	50mg	$66	2026-04-30	Buy
Cayman Chemical	24925	Catalpol ≥98%	2415-24-9	100mg	$117	2026-04-30	Buy

Product number	Packaging	Price	Buy
PHL89595	10MG	$570	Buy
50839	25mg	$348	Buy
C3494	250MG	$196	Buy
24925	50mg	$66	Buy
24925	100mg	$117	Buy

Catalpol Chemical Properties, Uses, Production

Description

Catalpol is an iridoid glycoside that has been isolated from R. glutinosa and has diverse biological activities, including anti-apoptotic, pro-angiogenic, and radioprotective properties. It protects against mitochondrial pathway-dependent apoptosis in PC12 rat adrenal pheochromocytoma cells and H9c2 rat embryonic ventricular myocardial cells when used at a concentration of 10 μM. Catalpol pretreatment reduces apoptosis and improves viability in AHH-1 human lymphocyte cells exposed to ionizing radiation and reduces intestinal damage induced by radiation in mice when used at concentrations and doses ranging from of 25 to 100 μg/ml and 25 to 100 mg/kg, respectively. In a rat model of stroke, catalpol (5 mg/kg, i.p.) increases the expression of erythropoietin and VEGF and improves angiogenesis in the brain.

Chemical Properties

Light brown powder

Uses

Catapol is an iridoid glucoside that has been shown to alleviate neuropathic pain.

Definition

ChEBI: Catalpol is an organic molecular entity. It has a role as a metabolite.

in vivo

Catalpol (25-100mg/kg; intraperitoneal injection; once) treatment clearly reduces blood urea nitrogen, serum creatinine levels and the expression of KIM-1 in renal ischemia/reperfusion-injury (IRI) mice. Catalpol markedly reduces the expression of PI3K, Akt and eNOS levels, and suppresses the TNF-α, IL-1β, IL-6 and IL-10 activities^[1].

Animal Model:	C57BL/6 mice treated with renal ischemia/reperfusion surgery^[1]
Dosage:	25 mg/kg, 50 mg/kg and 100mg/kg
Administration:	Intraperitoneal injection; once
Result:	Clearly reduced blood urea nitrogen, serum creatinine levels and the expression of KIM-1 in renal IRI mice.

References

[1] YANJIE WANG. Simultaneous Determination of Catalpol, Aucubin, and Geniposidic Acid in Different Developmental Stages of Rehmannia glutinosa Leaves by High Performance Liquid Chromatography.[J]. Journal of Analytical Methods in Chemistry, 2016, 2016: 4956589. DOI: 10.1155/2016/4956589
[2] WENNA CHEN. Neuroprotective activities of catalpol against CaMKII-dependent apoptosis induced by LPS in PC12 cells[J]. British Journal of Pharmacology, 2013, 169 5: 1140-1152. DOI: 10.1111/bph.12200
[3] LING-AI HU. Catalpol inhibits apoptosis in hydrogen peroxide-induced cardiac myocytes through a mitochondrial-dependent caspase pathway.[J]. Bioscience Reports, 2016, 36 3. DOI: 10.1042/bsr20160132
[4] CHENGJIE CHEN. Radio-protective effect of catalpol in cultured cells and mice.[J]. Journal of Radiation Research, 2013, 54 1: 76-82. DOI: 10.1093/jrr/rrs080
[5] HUI-FENG ZHU. Catalpol increases brain angiogenesis and up-regulates VEGF and EPO in the rat after permanent middle cerebral artery occlusion.[J]. International Journal of Biological Sciences, 2010, 6 5: 443-453. DOI: 10.7150/ijbs.6.443

Catalpol synthesis

Synthesis of Catalpol from [(1aS,1bα,5aα,6aβ)-2α-(β-D-Glucopyranosyloxy)-1a,1b,2,5a,6,6a-hexahydro-1aβ-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-6α-yl]α-D-galactopyranoside

Catalpol Preparation Products And Raw materials

Raw materials

3-Pentanone

Preparation Products

Catalpol Suppliers

Global Suppliers ( 326)

Supplier	Tel	Email	Country	ProdList	Advantage
ShangHai YuanYe Biotechnology Co., Ltd.	15026964105	shyysw007@163.com	China	4998	60
Nanjing Digger Medical Technology Co. Ltd.	025-025-51191215 18013836722	2399235533@qq.com	China	4932	58
Nanjing Dasf Biotechnology Co., Ltd.	16651696448	1773155960@qq.com	China	1990	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Shandong Xiya Chemical Co., Ltd	13355009207 13355009207	3007715519@qq.com	China	18722	57
Sichuan Kulinan Technology Co., Ltd	400-1166-196 18981987031	cdhxsj@163.com	China	11674	57
China Langchem Inc.	0086-21-58956006		China	7798	57
Sinopharm Chemical Reagent Co,Ltd.	86-21-63210123	sj_scrc@sinopharm.com	China	9791	79

Supplier	Advantage
ShangHai YuanYe Biotechnology Co., Ltd.	60
Nanjing Digger Medical Technology Co. Ltd.	58
Nanjing Dasf Biotechnology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Chembest Research Laboratories Limited	61
Beijing HwrkChemical Technology Co., Ltd	55
Shandong Xiya Chemical Co., Ltd	57
Sichuan Kulinan Technology Co., Ltd	57
China Langchem Inc.	57
Sinopharm Chemical Reagent Co,Ltd.	79

View Latest Price from Catalpol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	Catalpol 2415-24-9	$5.00	1KG	98%		Henan Fengda Chemical Co., Ltd
2026-06-30	Catalpol 2415-24-9		1kg	98%	10000kgs	Shaanxi Dideu New Materials Co. Ltd
2026-06-30	Catalpol 2415-24-9		1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

Catalpol
2415-24-9
$5.00
98%
Henan Fengda Chemical Co., Ltd

Catalpol
2415-24-9
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

Catalpol
2415-24-9
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

Catalpol Spectrum

Catalpol(2415-24-9)MS Catalpol(2415-24-9)¹HNMR

2415-24-9 (Catalpol) Related Search:

Citric acid Palmatine chloride alpha-Cyperone Verbascoside Salicylic acid

Ferulic Acid Artemisinin Dihydrocatalpol Picroside II VERPROSIDE

PICROSIDE I Catalpol [(1aS)-1a,1bα,2,5aα,6,6aβ-Hexahydro-6α-[(E)-3-(4-hydroxy-3-methoxyphenyl)propenoyloxy]-1aβ-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2α-yl]β-D-glucopyranoside 6-O-Cinnamoyl Catalpol Acetylcatalpol

gmelinol Catalpol std.,CATALPOL(RG) Catalpol(SH)

1of4

CATALPOL ,6-beta,6a-alpha))- beta-d-glucopyranoside,1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl) catalpinoside de(p-hydroxybenzoyl)catalposide des-p-hydroxybenzoyl-catalposid oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl,(1as-(1a-alpha,1b-beta,2-beta,5a-beta Catalpol 2415-24-9 Catalpol, ≥97%(HPLC) [1aS-(1aalpha,1bbeta,2beta,5abeta,6beta,6a.alpha.)]-1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl-beta-D-glucopyranoside .beta.-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno4,5cyclopenta1,2-cpyran-2-yl CATALPOL WITH HPLC 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl β-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)- Catalpol，Catalnol [(1aS)-1a,1bα,2,5aα,6,6aβ-Hexahydro-6α-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2α-yl]β-D-glucopyranoside Catapol ,>=98% (1AS-(1aα,1bβ,2β,5aβ,6β,6aα-))1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxyMethyl)oxireno(4,5)cyclopenta(1,2-c)-pyran-2-yl-beta-D-glucopyranoside (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-Hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl-β-D-glucopyranoside Digitalis purpurea L (3R,4S,5S,6R)-2-(((1aS,1bS,2S,5aR,6S,6aS)-6-Hydroxy-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[2',3':4,5]cyclopenta[1,2-c]pyran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol β-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl (2S,3R,4S,5S,6R)-2-[[(1aS,1bS,2S,5aR,6S,6aS)-6-hydroxy-1a-(hydroxymethyl)-2,5a,6,6a-tetrahydro-1bH-oxireno[5,6]cyclopenta[1,3-c]pyran-2-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol (2S,3R,4S,5S,6R)-2-(((1aS,1bS,2S,5aR,6S,6aS)-6-Hydroxy-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[2',3':4,5]cyclopenta[1,2-c]pyran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (2S, 3R, 4S, 5S, 6R) -2- (((1aS, 1bS, 2S, 5aR, 6S, 6aS) -6-hydroxy-1a - (hydroxymethyl) -1a, 1b, 2,5a, 6,6a - hexahydroepoxyethano [2 ', 3': 4,5] cyclopentadieno [1,2-c] pyran-2-yl) oxy) -6- (hydroxymethyl) tetrahydro-2H-pyran-3,4,5-triol Catalpol-RM Catalpol, 10 mM in DMSO (2S,3R,4S,5S,6R)-2-[[(1S,2S,4S,5S,6R,10S)-5-hydroxy-2-(hydroxymethyl)-3,9-dioxatricyclo[4.4.0.02,4]dec-7-en-10-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-Hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl β-D-glucopyranoside Catalpol (Standard) CATAPOL Catalpol (7CI, 8CI) 2415-24-9 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Inhibitors Iridoids