ChemicalBook >> CAS DataBase List >>Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, 6-[(1S)-1-[[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]carbonyl]oxy]ethyl] ester, (1S,2S,3S,5R,6S)-

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, 6-[(1S)-1-[[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]carbonyl]oxy]ethyl] ester, (1S,2S,3S,5R,6S)-

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, 6-[(1S)-1-[[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]carbonyl]oxy]ethyl] ester, (1S,2S,3S,5R,6S)- structure

CAS No.: 1501974-69-1

Chemical Name:: Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, 6-[(1S)-1-[[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]carbonyl]oxy]ethyl] ester, (1S,2S,3S,5R,6S)-

Synonyms: MGS0274;Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, 6-[(1S)-1-[[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]carbonyl]oxy]ethyl] ester, (1S,2S,3S,5R,6S)-

CBNumber:: CB68103552

Molecular Formula:: C21 H32 F N O7

Molecular Weight:: 429.48

MDL Number:

MOL File:: 1501974-69-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:42

Request For Quotation

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, 6-[(1S)-1-[[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]carbonyl]oxy]ethyl] ester, (1S,2S,3S,5R,6S)- Chemical Properties, Uses, Production

Description

MGS0274 besylate is a prodrug of a potent group II metabotropic glutamate receptor agonist MGS0008 for the treatment of schizophrenia.

Uses

MGS0274, an ester-based lipophilic proagent of a metabotropic glutamate (mGlu)2 and mGlu3 receptor agonist MGS0008, shows improved oral bioavailability. MGS0274 has the potential for the research of schizophrenia[1][2].

IC 50

mGluR2; mGluR3

References

[1] Urabe H, et al. Discovery of MGS0274, an ester prodrug of a metabotropic glutamate receptor 2/3 agonist with improved oral bioavailability [published online ahead of print, 2020 Jul 5]. Eur J Med Chem. 2020;203:112521. DOI:10.1016/j.ejmech.2020.112521
[2] Kinoshita K, et al. Preclinical disposition of MGS0274 besylate, a prodrug of a potent group II metabotropic glutamate receptor agonist MGS0008 for the treatment of schizophrenia. Pharmacol Res Perspect. 2019;7(5):e00520. Published 2019 Sep 13. DOI:10.1002/prp2.520

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, 6-[(1S)-1-[[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]carbonyl]oxy]ethyl] ester, (1S,2S,3S,5R,6S)- Preparation Products And Raw materials

Raw materials

Preparation Products

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, 6-[(1S)-1-[[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]carbonyl]oxy]ethyl] ester, (1S,2S,3S,5R,6S)- Suppliers

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TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

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TargetMol Chemicals Inc.	58

1501974-69-1 (Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, 6-[(1S)-1-[[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]carbonyl]oxy]ethyl] ester, (1S,2S,3S,5R,6S)-) Related Search:

LY 341495 Ro 67-7476 O-Phospho-L-serine N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide L-AP4

MTEP

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Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-3-fluoro-, 6-[(1S)-1-[[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]carbonyl]oxy]ethyl] ester, (1S,2S,3S,5R,6S)- MGS0274 1501974-69-1 C21H32FNO7