2-ACETYL-ISONICOTINONITRILE
- CAS No.
- 37398-49-5
- Chemical Name:
- 2-ACETYL-ISONICOTINONITRILE
- Synonyms
- 2-Acetyl-4-cyanopyridine;2-ACETYL-ISONICOTINONITRILE;2-acetyl-4-Pyridinecarbonitrile;4-Pyridinecarbonitrile, 2-acetyl-;4-Pyridinecarbonitrile, 2-acetyl- (9CI)
- CBNumber:
- CB6846745
- Molecular Formula:
- C8H6N2O
- Molecular Weight:
- 146.15
- MDL Number:
- MFCD07357443
- MOL File:
- 37398-49-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Acetylisonicotinonitrile | 295573 | 250.00mg | $73 |
| 2-Acetylisonicotinonitrile | 295573 | 1.00g | $174 |
| 2-Acetylisonicotinonitrile | 295573 | 5.00g | $609 |
| 2-Acetylisonicotinonitrile 95+% | A38324 | 100mg | $53 |
| 2-Acetylisonicotinonitrile 95+% | A38324 | 250mg | $60 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
2-ACETYL-ISONICOTINONITRILE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 295573 | 2-Acetylisonicotinonitrile | 37398-49-5 | 250.00mg | $73 | 2026-05-19 | Buy |
| Matrix Scientific | 295573 | 2-Acetylisonicotinonitrile | 37398-49-5 | 1.00g | $174 | 2026-05-19 | Buy |
| Matrix Scientific | 295573 | 2-Acetylisonicotinonitrile | 37398-49-5 | 5.00g | $609 | 2026-05-19 | Buy |
| Synthonix | A38324 | 2-Acetylisonicotinonitrile 95+% | 37398-49-5 | 100mg | $53 | 2026-05-06 | Buy |
| Synthonix | A38324 | 2-Acetylisonicotinonitrile 95+% | 37398-49-5 | 250mg | $60 | 2026-05-06 | Buy |
2-ACETYL-ISONICOTINONITRILE Chemical Properties,Uses,Production
Synthesis
100-48-1
541-50-4
37398-49-5
Step 1: In a reaction flask containing a mixed solution of dichloromethane (1300 mL) and water (1100 mL) with 4-cyanopyridine (52 g, 0.5 mol), ammonium persulfate ((NH4)2S2O8) (170 g, 0.75 mol), silver nitrate (6.8 g, 0.04 mol), and aqueous sulfuric acid (40 mL, prepared from 98 mL of concentrated sulfuric acid (prepared with 400 mL of water). Subsequently, a solution of 3-oxobutanoic acid (110 g, 1.25 mol) in dichloromethane (100 mL) was added slowly and dropwise while keeping the reaction mixture at reflux. After refluxing the reaction for 2 h, the reaction mixture was alkalized with sodium carbonate powder to pH 8-9. The reaction mixture was filtered and the filtrate was extracted with dichloromethane (500 mL x 3). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was recrystallized by ethanol to give 2-acetylisonicotinonitrile (52.0 g, 71.9% yield).
References
[1] Patent: WO2013/150416, 2013, A1. Location in patent: Page/Page column 117
2-ACETYL-ISONICOTINONITRILE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
2-ACETYL-ISONICOTINONITRILE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Hunan Jibang Biological Technology Co., LTD | +8613776644403 | sales02@kingboomtech.com | China | 1804 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +8613382787392 | sales@aeechem.com | China | 10001 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3989 | 55 |
| Struchem Co., Ltd. | 0512-63009836 18994340901 | helen@struchem.com | China | 3979 | 60 |
| Aikon International Limited | 025-66113011 19370895928 | qzhang@aikonchem.com | China | 15393 | 58 |
