2-Acetyl-isonicotinonitrile
- CAS No.
- 37398-49-5
- Chemical Name:
- 2-Acetyl-isonicotinonitrile
- Synonyms
- 2-Acetyl-4-cyanopyridine;2-Acetyl-isonicotinonitrile;2-acetyl-4-Pyridinecarbonitrile;4-Pyridinecarbonitrile, 2-acetyl-;4-Pyridinecarbonitrile, 2-acetyl- (9CI)
- CBNumber:
- CB6846745
- Molecular Formula:
- C8H6N2O
- Molecular Weight:
- 146.15
- MDL Number:
- MFCD07357443
- MOL File:
- 37398-49-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
2-Acetyl-isonicotinonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | MBA39849 | 2-Acetylisonicotinonitrile | 37398-49-5 | 1g | $330.4 | 2026-06-04 | Buy |
| Biosynth | MBA39849 | 2-Acetylisonicotinonitrile | 37398-49-5 | 10g | $1416 | 2026-06-04 | Buy |
| Activate Scientific | AS46110 | 2-Acetylisonicotinonitrile 96% | 37398-49-5 | 1g | $185 | 2026-06-04 | Buy |
| Activate Scientific | AS46110 | 2-Acetylisonicotinonitrile 96% | 37398-49-5 | 5g | $647 | 2026-06-04 | Buy |
| Matrix Scientific | 295573 | 2-Acetylisonicotinonitrile | 37398-49-5 | 250.00mg | $73 | 2026-05-19 | Buy |
2-Acetyl-isonicotinonitrile Chemical Properties, Uses, Production
Synthesis
100-48-1
541-50-4
37398-49-5
Step 1: In a reaction flask containing a mixed solution of dichloromethane (1300 mL) and water (1100 mL) with 4-cyanopyridine (52 g, 0.5 mol), ammonium persulfate ((NH4)2S2O8) (170 g, 0.75 mol), silver nitrate (6.8 g, 0.04 mol), and aqueous sulfuric acid (40 mL, prepared from 98 mL of concentrated sulfuric acid (prepared with 400 mL of water). Subsequently, a solution of 3-oxobutanoic acid (110 g, 1.25 mol) in dichloromethane (100 mL) was added slowly and dropwise while keeping the reaction mixture at reflux. After refluxing the reaction for 2 h, the reaction mixture was alkalized with sodium carbonate powder to pH 8-9. The reaction mixture was filtered and the filtrate was extracted with dichloromethane (500 mL x 3). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was recrystallized by ethanol to give 2-acetylisonicotinonitrile (52.0 g, 71.9% yield).
References
[1] Patent: WO2013/150416, 2013, A1. Location in patent: Page/Page column 117
2-Acetyl-isonicotinonitrile Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
2-Acetyl-isonicotinonitrile Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Struchem Co., Ltd. | 0512-63009836 18994340901 | helen@struchem.com | China | 3968 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-66113011 19370895928 | qzhang@aikonchem.com | China | 15390 | 58 |
| Zhuzhou focus pharmaceutical technology co., LTD | +86-13776644403 | robert@focuspharma.cc | China | 2613 | 58 |
| Hunan Jibang Biological Technology Co., LTD | 13776644403 | sales02@kingboomtech.com | China | 1803 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9897 | 58 |
| Henan Weituxi Chemical Technology Co., Ltd. | 0371-63284658 18135795563 | 3905209149@qq.com | China | 9707 | 58 |
| Shanghai Lanle Bird Industrial Co., Ltd. | 15021845385 | 765325601@qq.com | China | 3607 | 58 |
