4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide
![4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide Structure](CAS/20210305/GIF/2595314-46-6.gif)
- CAS No.
- 2595314-46-6
- Chemical Name:
- 4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide
- Synonyms
- 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-5,5-dioxo-4H-thieno[3,2-c]thiochromene-2-carboxamide;4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide
- CBNumber:
- CB69835205
- Molecular Formula:
- C34H27NO5S2
- Molecular Weight:
- 593.71
- MDL Number:
- MOL File:
- 2595314-46-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide Properties
| Boiling point | 907.9±65.0 °C(Predicted) |
|---|---|
| Density | 1.328±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 100 mg/mL (168.43 mM; Need ultrasonic) |
| pka | 12.62±0.20(Predicted) |
| form | Solid |
| color | Off-white to light yellow |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3837 | WEHI-9625 ≥98% (HPLC) | 2595314-46-6 | 10mg | $496 | 2026-04-30 | Buy |
| ChemScene | CS-0105122 | WEHI-9625 99.46% | 2595314-46-6 | 1mg | $217 | 2026-06-04 | Buy |
| ChemScene | CS-0105122 | WEHI-9625 99.46% | 2595314-46-6 | 5mg | $542 | 2026-06-04 | Buy |
| ChemScene | CS-0105122 | WEHI-9625 99.46% | 2595314-46-6 | 10mg | $921 | 2026-06-04 | Buy |
| ChemScene | CS-0105122 | WEHI-9625 99.46% | 2595314-46-6 | 25mg | $1950 | 2026-06-04 | Buy |
4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide Chemical Properties,Uses,Production
Uses
WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX[1].
Biological Activity
WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX[1]. WEHI-9625 (0-10 μM; Mcl1-/-Bax-/- MEFs cells) treatment could prevent cell death mediated by BAK and potently inhibits BIM BH3-induced loss of mitochondrial membrane potential in Bax-/-, but not Bak-/-, cells[1]. WEHI-9625 demonstrates that blocking apoptosis at an early stage was both advantageous and pharmacologically tractable[1].
in vivo
WEHI-9625 demonstrates that blocking apoptosis at an early stage was both advantageous and pharmacologically tractable[1].
IC 50
Bak; Bax
References
[1]. van Delft MF, et al. A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis. Nat Chem Biol. 2019 Oct 7.
4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide Preparation Products And Raw materials
Raw materials
Preparation Products
4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Fengyong Biotechnology Co., Ltd. | 021-10000000 13000000000 | gzj@abmole.cn | China | 9323 | 58 |
