ChemicalBook >> CAS DataBase List >>Dihydrocodeine trifluoroacetate

Dihydrocodeine trifluoroacetate

CAS No.
125-28-0
Chemical Name:
Dihydrocodeine trifluoroacetate
Synonyms
Didrate;Drocode;Nadeine;Parzone;Drocade;Cohydrin;Dihydrin;Novcodin;Dehacodin;Novicodin
CBNumber:
CB7100972
Molecular Formula:
C20H24F3NO4
Molecular Weight:
399.4
MDL Number:
MFCD02253008
MOL File:
125-28-0.mol
MSDS File:
SDS
Last updated:2026-09-12 18:54:26

Dihydrocodeine trifluoroacetate Properties

Melting point 112-113°
Boiling point bp15 248°
Density 1.1412 (rough estimate)
refractive index 1.5740 (estimate)
Flash point 9℃
storage temp. 2-8°C
solubility DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 10 mg/ml
form A neat solid
FDA UNII N9I9HDB855
EPA Substance Registry System Morphinan-6-ol, 4,5-epoxy-3-methoxy-17-methyl-, (5?,6?)- (125-28-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Skull and Crossbones (GHS06)Health Hazard (GHS08)
GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H370
Precautionary statements  P210-P260-P280-P301+P310-P311
Hazard Codes  F,T
Risk Statements  11-23/24/25-39/23/24/25
Safety Statements  7-16-36/37-45
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
REACH Registrations Active
NFPA 704
0
4 0

Dihydrocodeine trifluoroacetate price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical ISO60142 Dihydrocodeine (CRM) 125-28-0 1mg $24 2026-04-30 Buy
Cayman Chemical 37884 Dihydrocodeine ≥98% 125-28-0 5mg $74 2026-04-30 Buy
Cayman Chemical 37884 Dihydrocodeine ≥98% 125-28-0 25mg $311 2026-04-30 Buy
Cayman Chemical 15460 Dihydrocodeine ≥98% 125-28-0 1mg $24 2026-04-30 Buy
Product number Packaging Price Buy
ISO60142 1mg $24 Buy
37884 5mg $74 Buy
37884 25mg $311 Buy
15460 1mg $24 Buy

Dihydrocodeine trifluoroacetate Chemical Properties, Uses, Production

Description

Dihydrocodeine (Item No. 37884) is an analytical reference standard categorized as an opioid.1 Dihydrocodeine is an active metabolite of hydrocodone (Item Nos. ISO60144 | 15461 | 22166).2 Formulations containing dihydrocodeine have been used in the treatment of severe pain and have been associated with misuse and polypharmacy-related overdose.3 Dihydrocodeine is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.WARNING This product is not for human or veterinary use.

Originator

Bicodein,Uquifa

Definition

ChEBI: Dihydrocodeine is a morphinane alkaloid.

Manufacturing Process

The codein was reduced by hydrogen in the presence catalyst Pt (or Pd, or Ni) and 7,8-dihydrocodein was obtained.
To the 7,8-dihydrocodein tartaric acid was added and mixed, in the result 7,8- dihydrocodein bitartrate was obtained.

Therapeutic Function

Antitussive, Narcotic analgesic

Safety Profile

Poison by ingestion, intravenous, and subcutaneous routes. Human systemic effects by ingestion and subcutaneous routes: somnolence, miosis (pupillary constriction), and respiratory depression. An analgesic. Can cause drug dependency with repeated doses. When heated to decomposition it emits toxic fumes of NOx. See also CODEINE.

76-57-3
125-28-0
Synthesis of Dihydrocodeine trifluoroacetate from CODEINE

Dihydrocodeine trifluoroacetate Preparation Products And Raw materials

4,5-alpha-epoxy-3-methoxy-17-methyl-morphinan-6-alpha-o 4,5alpha-Epoxy-3-methoxy-17-methylmorphinan-6alpha-ol 6-alpha-hydrocodol 6alpha-Hydrocodol 6-Hydroxy-3-methoxy-N-methyl-4,5-epoxymorphinan 7,8-dihydro-codein 7,8-Dihydrocodeine 8,14-Dihydroneopine alpha-Hydrocodol Codeine, dihydro- Codhydrine Cohydrin Dehacodin DH-codeine Didrate Dihydrin Dihydrokodein Dihydroneopine Drocode Hydrocodeine Hydrocodin Morphinan-6alpha-ol, 4,5alpha-epoxy-3-methoxy-17-methyl- Morphinan-6-ol, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)- Nadeine Novcodin Novicodin Novicondin Paracodin Paracodine Parzone Rapacodin Rapocodin 3-Methoxy-12-methyl-5,6,7,7α,8,9-hexahydro-4aH-8,9c-iminoethanophenanthro[4,5-bcd]furan-5-ol 6α-Hydrocodol Codeine, 7,8-dihydro- (6CI) Morphinan-6-ol, 4,5-epoxy-3-methoxy-17-methyl-, (5α,6α)- Morphinan-6α-ol, 4,5α-epoxy-3-methoxy-17-methyl- (8CI) NSC 231319 α-Hydrocodol Dihydrocodeine (base and/or unspecified salts) Novicodine Dihydrocodeine HCl Dihydrocodeine hydrochloride solution RBOXVHNMENFORY-DNJOTXNNSA-N Drocade Dihydrocodeine (CRM) Dihydrocodeine trifluoroacetate 125-28-0 C18H23NO3C2HF3O