ChemicalBook >> CAS DataBase List >>2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole structure

CAS No.: 117977-21-6

Chemical Name:: 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole

Synonyms: rabeprazole sulphide;Rabeprazole Related CoMpound E;abeprazole Sulfide;Rabeprazole Sulfide;2-(((4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl)Methyl)thio)-1H-benzo[d]iMidazole;H 295/43;(+)-Limacine;Rabeprazole-3;(+)-Fangchinoline;Rabeprazole USP RC E

CBNumber:: CB7102567

Molecular Formula:: C18H21N3O2S

Molecular Weight:: 343.45

MDL Number:: MFCD08063845

MOL File:: 117977-21-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-03 11:24:09

Request For Quotation

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole Properties

Melting point	120.5-121.50C
Boiling point	546.4±60.0 °C(Predicted)
Density	1.25±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	10.60±0.10(Predicted)
color	White to Off-White
InChI	InChI=1S/C18H21N3O2S/c1-13-16(19-9-8-17(13)23-11-5-10-22-2)12-24-18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21)
InChIKey	BSXAHDOWMOSVAP-UHFFFAOYSA-N
SMILES	C1(SCC2=NC=CC(OCCCOC)=C2C)NC2=CC=CC=C2N=1
CAS DataBase Reference	117977-21-6(CAS DataBase Reference)
FDA UNII	304S7E320P
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H413

Precautionary statements

P264-P270-P273-P301+P312-P501

HS Code

2933998350

REACH Registrations

Active

NFPA 704

	0
2		0

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole price More Price(63)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR3124	Rabeprazole Related Compound E pharmaceutical secondary standard, certified reference material	117977-21-6	50MG	$620	2026-04-30	Buy
TCI Chemical	R0098	Rabeprazole Sulfide >98.0%(HPLC)(T)	117977-21-6	200mg	$37	2026-04-30	Buy
TCI Chemical	R0098	Rabeprazole Sulfide >98.0%(HPLC)(T)	117977-21-6	1g	$110	2026-04-30	Buy
Cayman Chemical	36276	Rabeprazole Sulfide ≥98%	117977-21-6	250mg	$32	2026-04-30	Buy
Cayman Chemical	36276	Rabeprazole Sulfide ≥98%	117977-21-6	500mg	$61	2026-04-30	Buy

Product number	Packaging	Price	Buy
PHR3124	50MG	$620	Buy
R0098	200mg	$37	Buy
R0098	1g	$110	Buy
36276	250mg	$32	Buy
36276	500mg	$61	Buy

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole Chemical Properties,Uses,Production

Chemical Properties

Off-White Crystalline Powder

Uses

Rabeprazole Sulfide (Rabeprazole EP Impurity B) is a metabolite of Rabeprazole (R070500).

Synthesis

2-Hydroxymethyl-3-methyl-4-(3-methoxy propanoxyl)pyridine

118175-10-3

134469-07-1

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole

117977-21-6

General procedure for the synthesis of 2-[[[4-(3-methoxypropoxy)-3-methylpyrimidin-2-yl]methyl]thio]-1H-benzimidazole from 2-hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine and 1H-benzo[d]imidazole-2-thiol: 100 g of 2-hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine ( 473.35 mmol) in a 2L three-necked flask, 1 L of tetrahydrofuran was added as solvent, followed by 71.10 g of 1H-benzo[d]imidazole-2-thiol (473.35 mmol) and 136.58 g of triphenylphosphine (520.69 mmol). Stirring was turned on and the reaction temperature was controlled at 0 °C. Slowly 90.678 g of diethyl azodicarboxylate (520.69 mmol) was added dropwise. After the dropwise addition, the reaction was maintained for 5h to 10h, during which the reaction progress was monitored by TLC. Upon completion of the reaction, the tetrahydrofuran was evaporated to dryness by rotary evaporator, and the resulting crude product was purified by recrystallization from methanol to give 130.0 g of the target product 2-[[[4-(3-methoxypropoxy)-3-methylpyrimidin-2-yl]methyl]thio]-1H-benzimidazole in 80% yield.

References

[1] Patent: CN106674198, 2017, A. Location in patent: Paragraph 0020-0021

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole Preparation Products And Raw materials

Raw materials

2-Hydroxymethyl-3-methyl-4-(3-methoxy propanoxyl)pyridine 2-Chloromethyl-4-(3-methoxypropoxy)-3-methylpyridin 1H-Benzoimidazole-2-thiol Diethyl azodicarboxylate Triphenylphosphine

Tetrahydrofuran

1of2

Preparation Products

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole Suppliers

Global( 397)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Joiny Pharmaceutical Co.,Ltd.	13681955282	gyd@joiny-pharma.com	China	431	58
Xiamen keerda Biotechnology Co., Ltd	0592-5639388; 18060983084	753760940@qq.com	China	132	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6746	52

Supplier	Advantage
Shanghai Joiny Pharmaceutical Co.,Ltd.	58
Xiamen keerda Biotechnology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
TCI (Shanghai) Development Co., Ltd.	81
Beijing Ouhe Technology Co., Ltd	60
Pure Chemistry Scientific Inc.	62
Adamas Reagent, Ltd.	59
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
XiaoGan ShenYuan ChemPharm co,ltd	52

View Lastest Price from 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole 117977-21-6	$1.10	1g	99.00%	100 Tons min	Dideu Industries Group Limited
2026-06-30	2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole 117977-21-6		1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2026-06-02	Rabeprazole Sulfide 117977-21-6	$29.00		99.80%	10g	TargetMol Chemicals Inc.

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole
117977-21-6
$1.10
99.00%
Dideu Industries Group Limited

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole
117977-21-6
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

Rabeprazole Sulfide
117977-21-6
$29.00
99.80%
TargetMol Chemicals Inc.

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole Spectrum

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole(117977-21-6)¹HNMR

117977-21-6(2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole)Related Search:

1-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]-2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole RaBeprazole Impurity H (S)-Rabeprazole Sodium Salt N-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl] Rabeprazole Sulfone 4-Desmethoxypropoxyl-4-chloro Rabeprazole Sulfone

4-Desmethoxypropoxyl-4-chloro Rabeprazole 4-Nitro-2,3-lutidine-N-oxide Rabeprazole IMpurity G Rabeprazole Rebeprazole sodium

4-[(1H-Benzimidazol-2-yl)oxy]-3-methyl-2-pyridinecarboxylic Acid Discontinued See: B203960 Rabeprazole Impurity 2 2-[(4-Chloro-3-Methyl-2-Pyridinyl-methyl)thio]-1H-Benzimidazole Rabeprazole Impurity 2 Rabeprazole Related CoMpound A

Rabeprazole Impurity 8 1H-Benzimidazole-2-sulfonic acid Rabeprazole N-oxide

1of4

2-[(4-METHOXYPROPOXY-3-METHYL-2-PYRIDINYL)-METHYLTHIO]-BENZIMIDAZOLE 2-[[(3-METHYL-4-(3-METHOXYPROPOXY)PYRIDINYL)METHYL]THIO]-1H-BENZIMIDAZOLE Rabeprazole IMpurity F rabeprazole sulphide 2-[[4-(3-Methoxypropoxy)-3-Methyl-2-pyridyl]Methylthio]benziMidazole Rabeprazole Sulfide IMpurity 2-[[4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl]Methylsulfanyl]-1h-benziMidazole Rabeprazole Related Compound E (25 mg) (2-{[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio}benzimidazole) Rabeprazole USP RC E Rabeprazole Related CoMpound E Rabeprazole EP Impurity B Rabeprazole Related Compound E (2-{[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio}benzimidazole) 2-[[4-(3-Methoxypropoxy)-3-methyl-pyridin-2-yl]methylthio]benzoimidazole 2-[[(4-(3-Methoxypropoxy)- 3-methyl-2-pyridinyl)-2-methyl]thio]- 1H-benzimidazole 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl) Rabeprazole Impurity 7 Rabeprazole Sodium Impurity Ⅲ:2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole Rabeprazole EP Impurity B (Rabeprazole Sulfide) Rabeprazole-3 2-[[[4-(3-Methoxypropoxy)-3-methylpyridinyl] methyl]thio]- 1H-benzimidazole (RabeSulphide) Rabeprazole USP Related Compound E 2-[[[4-(3-Methoxypropoxy)-3-methylpiridine-2-yl]methyl]thio]-1H-benzimidazole 2-[[[4-(3-METHOXYPROPOXY)3-METHYL-2-PYRIDINYL] METHYL]THIO]1HBENZIMIDAZOLE 2-[[[4-(3-METHOXY PROPOXY)-3-METHYL PYRIDINE-2-YL]METHYL] THIO]-1H-BENZIMIDAZOLE 2-([4-(3-METHOXYPROPOXY)-3-METHYLPYRIDINE-2-YL]-METHYTHIO)1H-BENZIMIDAZOLE 2-[[4-(3-METHOXYPROPOXY)-3-METHYLPYRIDIN-2-YL]METHYLTHIO}-1H-BENZIMIDAZOLE 2-[{4-(3-MethoxyPropoxy)-3-MethylPyridine-2-Yi}-Methylthio]-1H-Benzimidazole H 295/43 2-[[[3-Methyl-4-(3-methoxypropoxy)-2-pyridyl]methyl]thio]-1H-benzimidazole Rabeprazole Sulfide Rabeprazole Thioether 2-{[4-(3-methoxypropoxy)-3-met Rebeprazole thioether 1H-Benzimidazole, 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]- 2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine hydro 2-{[4-(3-Methoxypropoxy)-3-Methylpyridine-2-yl]Met 2-({[4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl]Methyl}sulfanyl)-1H-1,3-benzodiazole Rabeprazole Sulfide > 2-[[[4-(3-Methoxypropoxy)-3-methyl- Rabeprazole Impurity 3（Rabeprazole EP Impurity B） 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole ISO 9001：2015 REACH abeprazole Sulfide Rabeprazole EP Impurity B/ Rabeprazole Related Compound E (Rabeprazole Sulfide) Rabeprazole USP Related Compound E.doc 2-{[4-(3-Methoxypropoxy)-3-Methylpyridine-2-Yl]-Methythio}-1... Rabeprazole sulphideQ: What is Rabeprazole sulphide Q: What is the CAS Number of Rabeprazole sulphide Q: What is the storage condition of Rabeprazole sulphide 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole/Rabeprazole sulfide Rabeprazole Related Compound E (2-{[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio}benzimidazol (1598064) (+)-Fangchinoline (+)-Limacine Rabeprazole Sulfide (Rabeprazole Impurity) 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2- yl]methylthio}-1H-benzimidazole (Rabe Sulphide) 2-[[[4-(3-Methoxypropoxy)-3-Methylpyridinyl] Methyl]Thio]- 1H-Benzimidazole (Sulp) 2-(((4-(3-methoxypropoxy)-3-methylpyridine-2-yl) methyl) thio)-1H-benzo[d]imidazole Ribeprazole condensate 2-[[[4-(3-Methoxy Propoxy-3-mthyl-2Pyridyl] Methyl]Thio]-1H-Benzimidazole Rabeprazole Sulfide / Rabeprazole Related Compound-E Rabeprazole EP Impurity B Rabeprazole USP Related Compound E