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1-(2,6-Difluorophenyl)ethan-1-one

1-(2,6-Difluorophenyl)ethan-1-one Structure
1-(2,6-Difluorophenyl)ethan-1-one structure
CAS No.
13670-99-0
Chemical Name:
1-(2,6-Difluorophenyl)ethan-1-one
Synonyms
TIMTEC-BB SBB006686;2,6-DIFLUOROACETOPHENONE;2',6'-difluoroacetophenone;2',6'-Difluoroacetophenone>2',6'-Difluoroacetophenone98%;Acetophenone, 2',6'-difluoro-;1-(2,6-Difluorophenyl)ethanone;2',6'-Difluoroacetophenone 98%;Benzamide,4-(1,4-dimethylethyl)-;1-(2,6-difluorophenyl)ethan-1-one
CBNumber:
CB7119307
Molecular Formula:
C8H6F2O
Molecular Weight:
156.13
MDL Number:
MFCD00000328
MOL File:
13670-99-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:21:07
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1-(2,6-Difluorophenyl)ethan-1-one Properties

Melting point 52-55°C
Boiling point 76-79 °C15 mm Hg(lit.)
Density 1.197 g/mL at 25 °C(lit.)
refractive index n20/D 1.48(lit.)
Flash point 170 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Liquid
Specific Gravity 1.197
color Clear colorless to slightly yellow
Water Solubility Slightly soluble in water.
BRN 2046068
InChI InChI=1S/C8H6F2O/c1-5(11)8-6(9)3-2-4-7(8)10/h2-4H,1H3
InChIKey VGIIILXIQLXVLC-UHFFFAOYSA-N
SMILES C1C(F)=C(C(=O)C)C(F)=CC=1
CAS DataBase Reference 13670-99-0(CAS DataBase Reference)
NIST Chemistry Reference Ethanone, 1-(2,6-difluorophenyl)-(13670-99-0)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37/39
WGK Germany  3
HazardClass  IRRITANT
HS Code  29147000
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
2
2 0

1-(2,6-Difluorophenyl)ethan-1-one price More Price(57)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 232890 2′,6′-Difluoroacetophenone 97% 13670-99-0 1g $27.6 2023-06-20 Buy
Sigma-Aldrich 232890 2′,6′-Difluoroacetophenone 97% 13670-99-0 5g $55.6 2023-06-20 Buy
TCI Chemical D3559 2',6'-Difluoroacetophenone >98.0%(GC) 13670-99-0 5g $71 2026-04-30 Buy
TCI Chemical D3559 2',6'-Difluoroacetophenone >98.0%(GC) 13670-99-0 25g $286 2026-04-30 Buy
Apolloscientific PC2577 2',6'-Difluoroacetophenone 97% 13670-99-0 5g $21 2026-06-04 Buy
Product number Packaging Price Buy
232890 1g $27.6 Buy
232890 5g $55.6 Buy
D3559 5g $71 Buy
D3559 25g $286 Buy
PC2577 5g $21 Buy

1-(2,6-Difluorophenyl)ethan-1-one Chemical Properties,Uses,Production

Chemical Properties

Clear colourless to light yellow liquid

Uses

2,6-Difluoroacetophenone was used in the synthesis of 2-amino-4-alkyl- and 2-amino-4-arylquinazolines.

General Description

2′,6′-Difluoroacetophenone undergoes ruthenium-catalyzed phenylation with phenylboronate via carbon-fluorine bond cleavage to yield 2′,6′-diphenylacetophenone.

Synthesis

2,6-Difluorobenzoyl chloride

18063-02-0

Diethyl malonate

105-53-3

1-(2,6-Difluorophenyl)ethan-1-one

13670-99-0

GENERAL STEPS: Magnesium chloride (1.65 g, 17.3 mmol) was added to a solution of diethyl malonate (1.24 g, 7.7 mmol) in ethyl acetate (20 mL) and the mixture was stirred at room temperature for 30 minutes. Subsequently, triethylamine (2.35 mL, 16.7 mmol) was added and stirring was continued for 30 minutes. The reaction mixture was cooled to 0 °C and a solution of ethyl acetate (5 mL) of 2,6-difluorobenzoyl chloride (1.0 g, 5.6 mmol) was slowly added dropwise over a period of 15 min, ensuring that the internal temperature did not exceed 5 °C. After dropwise addition, the reaction mixture was returned to room temperature and stirred for 3 hours. Upon completion of the reaction, the reaction was quenched with 1N hydrochloric acid (50 mL) and extracted with ethyl acetate (100 mL). The organic phase was separated, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to give the intermediate (1.97 g) as a colorless oil. The oil was dissolved in acetonitrile (25 mL), water (2 mL) was added, and the solution was transferred to a pressure reactor and sealed. The mixture was heated to 150 °C and kept for 1 hour. At the end of the reaction, it was cooled to room temperature and the pressure was released. The yield of 2,6-difluoroacetophenone was determined to be 874 mg (100% yield) by HPLC weight analysis.

References

[1] Patent: WO2013/85686, 2013, A1. Location in patent: Page/Page column 22

1-(2,6-Difluorophenyl)ethan-1-one Preparation Products And Raw materials

Raw materials

2,6-Difluorobenzonitrile Ethyl potassium malonate 2,6-Difluorobenzoyl chloride Methylmagnesium chloride Diethyl malonate
Ethyl acetate Magnesium chloride Triethylamine

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Preparation Products

(r)-1-(2,6-difluorophenyl)ethanaMine-hcl 4-Fluoro (1H)indazole Pyrrole Methyl 3-(bromomethyl)-4-fluorobenzo[b]thiophene-2-carboxylate

1-(2,6-Difluorophenyl)ethan-1-one Suppliers

Global( 286)Suppliers
Supplier Tel Email Country ProdList Advantage
Changzhou Yanji Biotechnology Co., Ltd. 0519-83556355 18015005120 shikewei397@163.com China 3732 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
Changzhou Yanji Biotechnology Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Ark Pharm, Inc. 56
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66

View Lastest Price from 1-(2,6-Difluorophenyl)ethan-1-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-(2,6-Difluorophenyl)ethan-1-one pictures 2026-03-20 1-(2,6-Difluorophenyl)ethan-1-one
13670-99-0
 $10.00 1KG 99% 5tons Hebei Chuanghai Biotechnology Co., Ltd
1-(2,6-Difluorophenyl)ethanone pictures 2024-04-28 1-(2,6-Difluorophenyl)ethanone
13670-99-0
 $5.00 1kg 99.92% 50000tons Ouhuang Engineering Materials (Hubei) Co., Ltd
2',6'-Difluoroacetophenone pictures 2022-01-27 2',6'-Difluoroacetophenone
13670-99-0
 1KG 98.2% 100 tons Honest Joy Holdings Limited

1-(2,6-Difluorophenyl)ethan-1-one Spectrum

1-(2,6-Difluorophenyl)ethan-1-one(13670-99-0)MS1-(2,6-Difluorophenyl)ethan-1-one(13670-99-0)1HNMR1-(2,6-Difluorophenyl)ethan-1-one(13670-99-0)13CNMR1-(2,6-Difluorophenyl)ethan-1-one(13670-99-0)IR11-(2,6-Difluorophenyl)ethan-1-one(13670-99-0)Raman

13670-99-0(1-(2,6-Difluorophenyl)ethan-1-one)Related Search:

2',3',4',5',6'-PENTAFLUOROACETOPHENONE Ethyl (pentafluorobenzoyl)acetate 2-Chloro-2',4'-difluoroacetophenone 4-AMINO-3,5-DIFLUOROACETOPHENONE 1-(2,6-Difluorophenyl)ethan-1-one
2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone Decafluorobenzophenone 2,3,4,5,6-Pentafluorobenzophenone 2-Chloro-2,2-difluoroacetophenone 2',6'-Difluoropropiophenone
2,6-Difluorobenzophenone 2',4',6'-Trifluoroacetophenone 3'-Chloro-2',6'-difluoroacetophenone 2',3',6'-Trifluoroacetophenone 2-Chloro-2',5'-difluoroacetophenone
Pentafluorophenacyl bromide 2',3',6'-Trifluoropropiophenone 2'',4'',6''-Trifluoropropiophenone

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1-(2,6-Difluorophenyl)ethanone Acetophenone, 2',6'-difluoro- TIMTEC-BB SBB006686 2,6-DIFLUOROACETOPHENONE 1-(2,6-difluorophenyl)ethan-1-one 2',6'-Difluoroacetophenone 98% 2',6'-Difluoroacetophenone98% Ethanone, 1-(2,6-difluorophenyl)- 1-(2,6-Difluorophenyl)ethan-1-one, 1-(2,6-Difluorophenyl)-1-oxoethane 2',6'-Difluoroacetophenone> Benzamide,4-(1,4-dimethylethyl)- 2',6'-difluoroacetophenone 2′,6′-Difluoroacetophenone, CAS 13670-99-0 13670-99-0 F2C6H3COCH3 C8H6F2O KETONE Carbonyl Compounds C7 to C8 Building Blocks Ketones Organic Building Blocks Fluorine series Indolines ,Indoles C7 to C8 Carbonyl Compounds Ketones Aromatic Acetophenones & Derivatives (substituted) ketone Fluorobenzene Miscellaneous Adehydes, Acetals & Ketones Fluorine Compounds