2-Chloro-2',5'-difluoroacetophenone
- CAS No.
- 60468-36-2
- Chemical Name:
- 2-Chloro-2',5'-difluoroacetophenone
- Synonyms
- 5-DIFLUOROACETOPHENONE;2,5-difluorophenacyl chloride;2-CHLORO-2,5-DIFLUOROACETOPHENONE;2-Chloro-2',5'-difluoracetophenone;2-Chloro-2',5-difluoroacetophenone;2-Chloro-2',5'-difluoroacetophenone;a-Chloro-2',5'-difluoroacetophenone;2-chloro-1-(2,5-difluorophenyl)ethanone;Ethanone, 2-chloro-1-(2,5-difluorophenyl)-;2-Chloro-2′,5′-difluoroacetophenone, CAS 60468-36-2
- CBNumber:
- CB0723282
- Molecular Formula:
- C8H5ClF2O
- Molecular Weight:
- 190.57
- MDL Number:
- MFCD04115827
- MOL File:
- 60468-36-2.mol
- MSDS File:
- SDS
| Melting point | 49-50 °C(Solv: ethanol (64-17-5); water (7732-18-5)) |
|---|---|
| Boiling point | 240.5±25.0 °C(Predicted) |
| Density | 1.353±0.06 g/cm3(Predicted) |
| storage temp. | Storage temp. 2-8°C |
| Appearance | Off-white to light brown Solid |
| InChI | InChI=1S/C8H5ClF2O/c9-4-8(12)6-3-5(10)1-2-7(6)11/h1-3H,4H2 |
| InChIKey | HJWDDTDVBUFTCP-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC(F)=CC=C1F)CCl |
| CAS DataBase Reference | 60468-36-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Hazard Codes | Xi |
|---|---|
| HazardClass | IRRITANT |
| HS Code | 2914790090 |
2-Chloro-2',5'-difluoroacetophenone price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FC31686 | 2-Chloro-2',5'-difluoroacetophenone - 90% | 60468-36-2 | 100g | $230 | 2026-06-04 | Buy |
| Biosynth | FC31686 | 2-Chloro-2',5'-difluoroacetophenone - 90% | 60468-36-2 | 250g | $415 | 2026-06-04 | Buy |
| Apolloscientific | PC1489 | 2-Chloro-2',5'-difluoroacetophenone >98% | 60468-36-2 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC1489 | 2-Chloro-2',5'-difluoroacetophenone >98% | 60468-36-2 | 25g | $70 | 2026-06-04 | Buy |
| Apolloscientific | PC1489 | 2-Chloro-2',5'-difluoroacetophenone >98% | 60468-36-2 | 100g | $258 | 2026-06-04 | Buy |
2-Chloro-2',5'-difluoroacetophenone Chemical Properties,Uses,Production
Chemical Properties
White solid powder
Uses
2-Chloro-2'',5''-difluoroacetophenone
Synthesis
540-36-3
79-04-9
60468-36-2
To a suspension containing aluminum trichloride (34.59 g, 259 mmol) and 1,4-difluorobenzene (20 g, 18.18 mL, 175.3 mmol), chloroacetyl chloride (21.778 g, 192.83 mmol) was slowly added dropwise at 0 °C, and the dropwise addition process was controlled to be completed within 20 minutes. The reaction mixture was stirred at 0 °C for 1 h and then warmed up to 60 °C to continue the reaction for 1 h until a clarified solution was formed. Subsequently, the reaction solution was carefully poured into about 400 mL of ice-cold 1 M hydrochloric acid. At this point, a colorless solid precipitated. The aqueous phase was extracted with ether (3 x 50 mL) and the combined organic phases were washed with saturated sodium bicarbonate solution (40 mL) and dried over anhydrous magnesium sulfate. Finally, the organic phase was concentrated by rotary evaporator to give 27.93 g (84% yield) of the colorless crystalline product 2-chloro-2',5'-difluoroacetophenone.
References
[1] Patent: WO2015/139859, 2015, A1. Location in patent: Paragraph 0079
[2] Organic Letters, 2007, vol. 9, # 4, p. 667 - 669
[3] Pharmazie, 1976, vol. 31, # 6, p. 351 - 354
[4] Tetrahedron Asymmetry, 2007, vol. 18, # 8, p. 949 - 962
2-Chloro-2',5'-difluoroacetophenone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Rydberg Biotechnology Co., Ltd | 13616542515 | 3845715621@qq.com | China | 91 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Liaoning Tianhua Chemical Co., Ltd. | 0418-6530555 2855550 | China | 338 | 69 | |
| Suzhou Chireach Biomedical Technology Co., Ltd. | 0512-65856968 | sales@chireach.com | China | 59 | 70 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
View Lastest Price from 2-Chloro-2',5'-difluoroacetophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2-Chloro-1-(2,5-difluorophenyl)ethanone
60468-36-2
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2021-08-12 | 2-CHLORO-2",5"-DIFLUOROACETOPHENONE
60468-36-2
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-09-02 | 2-CHLORO-2',5'-DIFLUOROACETOPHENONE
60468-36-2
|
$7.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 2-Chloro-1-(2,5-difluorophenyl)ethanone
60468-36-2
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 2-CHLORO-2",5"-DIFLUOROACETOPHENONE
60468-36-2
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-CHLORO-2',5'-DIFLUOROACETOPHENONE
60468-36-2
- $7.00
- 99%
- Career Henan Chemical Co
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