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2-CHLORO-2',5'-DIFLUOROACETOPHENONE

2-CHLORO-2',5'-DIFLUOROACETOPHENONE structure

CAS No.: 60468-36-2

Chemical Name:: 2-CHLORO-2',5'-DIFLUOROACETOPHENONE

Synonyms: 5-DIFLUOROACETOPHENONE;2,5-difluorophenacyl chloride;2-CHLORO-2,5-DIFLUOROACETOPHENONE;2-Chloro-2',5'-difluoracetophenone;2-Chloro-2',5-difluoroacetophenone;2-Chloro-2',5'-difluoroacetophenone;a-Chloro-2',5'-difluoroacetophenone;2-chloro-1-(2,5-difluorophenyl)ethanone;Ethanone, 2-chloro-1-(2,5-difluorophenyl)-;2-Chloro-2′,5′-difluoroacetophenone, CAS 60468-36-2

CBNumber:: CB0723282

Molecular Formula:: C8H5ClF2O

Molecular Weight:: 190.57

MDL Number:: MFCD04115827

MOL File:: 60468-36-2.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:50

Product description	Number	Pack Size	Price
2-Chloro-2',5'-difluoroacetophenone - 90%	FC31686	100g	$230
2-Chloro-2',5'-difluoroacetophenone - 90%	FC31686	250g	$415
2-Chloro-2',5'-difluoroacetophenone >98%	PC1489	5g	$21
2-Chloro-2',5'-difluoroacetophenone >98%	PC1489	25g	$70
2-Chloro-2',5'-difluoroacetophenone >98%	PC1489	100g	$258
More product size

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2-CHLORO-2',5'-DIFLUOROACETOPHENONE Properties

Melting point	49-50 °C(Solv: ethanol (64-17-5); water (7732-18-5))
Boiling point	240.5±25.0 °C(Predicted)
Density	1.353±0.06 g/cm3(Predicted)
storage temp.	Storage temp. 2-8°C
Appearance	Off-white to light brown Solid
InChI	InChI=1S/C8H5ClF2O/c9-4-8(12)6-3-5(10)1-2-7(6)11/h1-3H,4H2
InChIKey	HJWDDTDVBUFTCP-UHFFFAOYSA-N
SMILES	C(=O)(C1=CC(F)=CC=C1F)CCl
CAS DataBase Reference	60468-36-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Hazard Codes	Xi
HazardClass	IRRITANT
HS Code	2914790090

2-CHLORO-2',5'-DIFLUOROACETOPHENONE price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	FC31686	2-Chloro-2',5'-difluoroacetophenone - 90%	60468-36-2	100g	$230	2026-06-04	Buy
Biosynth	FC31686	2-Chloro-2',5'-difluoroacetophenone - 90%	60468-36-2	250g	$415	2026-06-04	Buy
Apolloscientific	PC1489	2-Chloro-2',5'-difluoroacetophenone >98%	60468-36-2	5g	$21	2026-06-04	Buy
Apolloscientific	PC1489	2-Chloro-2',5'-difluoroacetophenone >98%	60468-36-2	25g	$70	2026-06-04	Buy
Apolloscientific	PC1489	2-Chloro-2',5'-difluoroacetophenone >98%	60468-36-2	100g	$258	2026-06-04	Buy

Product number	Packaging	Price	Buy
FC31686	100g	$230	Buy
FC31686	250g	$415	Buy
PC1489	5g	$21	Buy
PC1489	25g	$70	Buy
PC1489	100g	$258	Buy

2-CHLORO-2',5'-DIFLUOROACETOPHENONE Chemical Properties,Uses,Production

Chemical Properties

White solid powder

Uses

2-Chloro-2'',5''-difluoroacetophenone

Synthesis

540-36-3

79-04-9

60468-36-2

To a suspension containing aluminum trichloride (34.59 g, 259 mmol) and 1,4-difluorobenzene (20 g, 18.18 mL, 175.3 mmol), chloroacetyl chloride (21.778 g, 192.83 mmol) was slowly added dropwise at 0 °C, and the dropwise addition process was controlled to be completed within 20 minutes. The reaction mixture was stirred at 0 °C for 1 h and then warmed up to 60 °C to continue the reaction for 1 h until a clarified solution was formed. Subsequently, the reaction solution was carefully poured into about 400 mL of ice-cold 1 M hydrochloric acid. At this point, a colorless solid precipitated. The aqueous phase was extracted with ether (3 x 50 mL) and the combined organic phases were washed with saturated sodium bicarbonate solution (40 mL) and dried over anhydrous magnesium sulfate. Finally, the organic phase was concentrated by rotary evaporator to give 27.93 g (84% yield) of the colorless crystalline product 2-chloro-2',5'-difluoroacetophenone.

References

[1] Patent: WO2015/139859, 2015, A1. Location in patent: Paragraph 0079
[2] Organic Letters, 2007, vol. 9, # 4, p. 667 - 669
[3] Pharmazie, 1976, vol. 31, # 6, p. 351 - 354
[4] Tetrahedron Asymmetry, 2007, vol. 18, # 8, p. 949 - 962

2-CHLORO-2',5'-DIFLUOROACETOPHENONE Preparation Products And Raw materials

Raw materials

1,4-Difluorobenzene Chloroacetyl chloride

Preparation Products

2-CHLORO-2',5'-DIFLUOROACETOPHENONE Suppliers

Global( 155)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20121	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Changzhou Carman Chemical Co., Ltd.	15061933924		CHINA	514	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	9976	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14304	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Changzhou Carman Chemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Fuxin Pharmaceutical	58
Antai Fine Chemical Technology Co.,Limited	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Win-Win chemical CO., Limited	58

View Lastest Price from 2-CHLORO-2',5'-DIFLUOROACETOPHENONE manufacturers

Update time	Product	Price	Min. Order	Purity	Manufacturer
2026-07-09	2-Chloro-1-(2,5-difluorophenyl)ethanone 60468-36-2	$1.00-200.00	1KG	99%, 99.5% Sublimated	Henan Fengda Chemical Co., Ltd
2021-08-12	2-CHLORO-2",5"-DIFLUOROACETOPHENONE 60468-36-2	$10.00-15.00	1KG	99%+ HPLC	Zhuozhou Wenxi import and Export Co., Ltd
2019-09-02	2-CHLORO-2',5'-DIFLUOROACETOPHENONE 60468-36-2	$7.00	1KG	99%	Career Henan Chemical Co

2-Chloro-1-(2,5-difluorophenyl)ethanone
60468-36-2
$1.00-200.00
99%, 99.5% Sublimated
Henan Fengda Chemical Co., Ltd

2-CHLORO-2",5"-DIFLUOROACETOPHENONE
60468-36-2
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2-CHLORO-2',5'-DIFLUOROACETOPHENONE
60468-36-2
$7.00
99%
Career Henan Chemical Co

2-CHLORO-2',5'-DIFLUOROACETOPHENONE Spectrum

2-CHLORO-2',5'-DIFLUOROACETOPHENONE(60468-36-2)¹HNMR

60468-36-2(2-CHLORO-2',5'-DIFLUOROACETOPHENONE)Related Search:

2',5'-Difluoroacetophenone 4'-CHLORO-2',5'-DIFLUOROACETOPHENONE,4-CHLORO-2,5-DIFLUOROACETOPHENONE,4'-Chloro-2',5'-difluoroacetophenone 97%,4'-Chloro-2',5'-difluoroacetophenone97% 2-Chloro-4,5-difluorohypnone 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone 4'-CHLORO-2',6'-DIFLUOROACETOPHENONE

3'-CHLORO-2',6'-DIFLUOROACETOPHENONE 2-Chloro-3',4'-difluoroacetophenone A-CHLORO-2',4'-DIFLUOROACETOPHENONE 2-Chloro-2',4'-difluoroacetophenone 2-CHLORO-2,2-DIFLUOROACETOPHENONE

2-CHLORO-4,5-DIFLUOROACETOPHENONE,2'-CHLORO-4',5'-DIFLUOROACETOPHENONE 2-CHLORO-2',5'-DIFLUOROACETOPHENONE 1-(2-chloroethyl)-2-fluorobenzene 3-Fluorophenacyl Chloride 2-chloro-1-(2,5-difluorophenyl)propan-1-one

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2-CHLORO-2,5-DIFLUOROACETOPHENONE 2,5-difluorophenacyl chloride 2-chloro-1-(2,5-difluorophenyl)ethanone 2,5-difluorophenacyl chloride ,2-chloro-1-(2,5-difluorophenyl)ethanone 2-Chloro-1-(2,5-difluorophenyl)ethanone[2-Chloro-2',5'-difluoroacetophenone] Ethanone, 2-chloro-1-(2,5-difluorophenyl)- 2-CHLORO-2',5'-DIFLUOROACETOPHENONE ISO 9001：2015 REACH 5-DIFLUOROACETOPHENONE a-Chloro-2',5'-difluoroacetophenone 2-Chloro-2',5'-difluoroacetophenone 2-Chloro-2',5'-difluoracetophenone 2-Chloro-2',5-difluoroacetophenone 2-Chloro-2′,5′-difluoroacetophenone, CAS 60468-36-2 60468-36-2 C8H5CIF2O C8H5ClF2O Fluorine series Acetophenone series Aromatic Acetophenones & Derivatives (substituted) Benzene series