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2-Chloro-2,2-difluoroacetophenone

2-Chloro-2,2-difluoroacetophenone Structure
2-Chloro-2,2-difluoroacetophenone structure
CAS No.
384-67-8
Chemical Name:
2-Chloro-2,2-difluoroacetophenone
Synonyms
2-Chloro-2,2-difluoro-1-phenylethan-1-one;Ethanone, 2-chloro-2,2-difluoro-1-phenyl-;2-Chloro-2,2-d;CHLORODIFLUOROACETOPHENONE;Chlorodifluorobenzophenone;à,à-difluorophenacyl chloride;à-chloro-à,à-difluoroacetophene;A-CHLORO-A,A-DIFLUOROACETOPHENONE;α,α-Difluoro-α-chloroacetophenone;2-Chloro-2,2-difluoroacetophenone
CBNumber:
CB7297366
Molecular Formula:
C8H5ClF2O
Molecular Weight:
190.57
MDL Number:
MFCD00042123
MOL File:
384-67-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:54:54
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2-Chloro-2,2-difluoroacetophenone Properties

Melting point 102-103 °C
Boiling point 94-96 °C35 mm Hg(lit.)
Density 1.293 g/mL at 25 °C(lit.)
refractive index n20/D 1.497(lit.)
Flash point 163 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Difficult to mix.
form liquid
color Clear, colourless
BRN 2251448
InChI 1S/C8H5ClF2O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5H
InChIKey MNOONJNILVDLSW-UHFFFAOYSA-N
SMILES FC(F)(Cl)C(=O)c1ccccc1
CAS DataBase Reference 384-67-8(CAS DataBase Reference)
UNSPSC Code 12352101
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37
RIDADR  UN 3334
WGK Germany  3
F  19
Hazard Note  Irritant
HS Code  29147000
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
2
2 0

2-Chloro-2,2-difluoroacetophenone price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 792373 2-Chloro-2,2-difluoroacetophenone 95% 384-67-8 10g $328 2026-04-30 Buy
Sigma-Aldrich 792373 2-Chloro-2,2-difluoroacetophenone 95% 384-67-8 1g $63.2 2023-06-20 Buy
ChemScene CS-W015867 2-Chloro-2,2-difluoro-1-phenylethanone ≥95% 384-67-8 1g $48 2026-06-04 Buy
ChemScene CS-W015867 2-Chloro-2,2-difluoro-1-phenylethanone ≥95% 384-67-8 5g $84 2026-06-04 Buy
ChemScene CS-W015867 2-Chloro-2,2-difluoro-1-phenylethanone ≥95% 384-67-8 10g $168 2026-06-04 Buy
Product number Packaging Price Buy
792373 10g $328 Buy
792373 1g $63.2 Buy
CS-W015867 1g $48 Buy
CS-W015867 5g $84 Buy
CS-W015867 10g $168 Buy

2-Chloro-2,2-difluoroacetophenone Chemical Properties,Uses,Production

Description

Novel and non-ODS-based (ODS = ozone-depleting substance) difluorocarbene reagents for O- and N-difluoromethylation. PhCOCF2Cl reacts with a variety of structurally diverse phenol derivatives to produce aryl difluoromethyl ethers in good yields. PhSO2CF2Cl can react with a variety of structurally diverse phenol derivatives and N-heterocyclic compounds.

Uses

2-Chloro-2,2-difluoroacetophenone can be used:

  • As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
  • As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
  • As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.

General Description

2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem-difluoromethene derived compounds.

reaction suitability

reaction type: C-C Bond Formation

2-Chloro-2,2-difluoroacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

Ethanone, 2,2-difluoro-2-(methylthio)-1-phenyl- (9CI) 4-(Difluoromethoxy)-2-fluorobromobenzene

2-Chloro-2,2-difluoroacetophenone Suppliers

Global( 136)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Tongchuang Pharma(Suzhou). Co., Ltd. 0512-63263366 18912765016 tongtf110@sina.com China 984 62
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
Shanghai BeiZhuo Biotech Co., Ltd. 021-61119791,13386096464 bzswkf@foxmail.com China 3916 50
Supplier Advantage
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60
Syntechem Co.,Ltd 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Tongchuang Pharma(Suzhou). Co., Ltd. 62
Shanghai Topbiochem Technology Co., Ltd 58
Shanghai BeiZhuo Biotech Co., Ltd. 50

View Lastest Price from 2-Chloro-2,2-difluoroacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-2,2-difluoroacetophenone pictures 2022-02-22 2-Chloro-2,2-difluoroacetophenone
384-67-8
 1KG 97.8% 100 tons Honest Joy Holdings Limited

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CHLORODIFLUOROACETOPHENONE alpha,alpha-Difluorophenacyl chloride A-CHLORO-A,A-DIFLUOROACETOPHENONE ALPHA-CHLORO-ALPHA,ALPHA-DIFLUOROACETOPHENONE ChlorodifluoroMethyl phenyl ketone 2-Chloro-2,2-d 2-chloro-2,2-difluoro-1-phenylethanone 2-chloro-2,2-difluoro-1-phenyl-ethanone à,à-difluorophenacyl chloride à-chloro-à,à-difluoroacetophene 2-Chloro-2,2-difluoroacetophenone 97% 2-Chloro-2,2-difluoroacetophenone97% 2-CHLORO-2,2-DIFLUOROACETOPHENE, 96% 1-Phenyl-2,2-difluoro-2-chloroethanone Phenyl(chlorodifluoromethyl) ketone α,α-Difluoro-α-chloroacetophenone Ethanone, 2-chloro-2,2-difluoro-1-phenyl- Chlorodifluorobenzophenone 2-Chloro-2,2-difluoro-1-phenylethan-1-one 2-Chloro-2,2-difluoroacetophenone 384-67-8 C6H5COCF2Cl Fluorine series