ChemicalBook >> CAS DataBase List >>2-CHLORO-2,2-DIFLUOROACETOPHENONE

2-CHLORO-2,2-DIFLUOROACETOPHENONE

2-CHLORO-2,2-DIFLUOROACETOPHENONE structure

CAS No.: 384-67-8

Chemical Name:: 2-CHLORO-2,2-DIFLUOROACETOPHENONE

Synonyms: 2-Chloro-2,2-difluoro-1-phenylethan-1-one;Ethanone, 2-chloro-2,2-difluoro-1-phenyl-;2-Chloro-2,2-d;CHLORODIFLUOROACETOPHENONE;Chlorodifluorobenzophenone;à,à-difluorophenacyl chloride;à-chloro-à,à-difluoroacetophene;A-CHLORO-A,A-DIFLUOROACETOPHENONE;2-CHLORO-2,2-DIFLUOROACETOPHENONE;α,α-Difluoro-α-chloroacetophenone

CBNumber:: CB7297366

Molecular Formula:: C8H5ClF2O

Molecular Weight:: 190.57

MDL Number:: MFCD00042123

MOL File:: 384-67-8.mol

MSDS File:: SDS

Last updated:2025-07-14 15:27:00

Request For Quotation

2-CHLORO-2,2-DIFLUOROACETOPHENONE Properties

Melting point	102-103 °C
Boiling point	94-96 °C35 mm Hg(lit.)
Density	1.293 g/mL at 25 °C(lit.)
refractive index	n20/D 1.497(lit.)
Flash point	163 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Difficult to mix.
form	liquid
color	Clear, colourless
BRN	2251448
CAS DataBase Reference	384-67-8(CAS DataBase Reference)
UNSPSC Code	12352101
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-37

RIDADR

UN 3334

WGK Germany

Hazard Note

Irritant

HS Code

29147000

NFPA 704

	2
2		0

2-CHLORO-2,2-DIFLUOROACETOPHENONE price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	792373	2-Chloro-2,2-difluoroacetophenone 95%	384-67-8	10g	$308	2025-07-31	Buy
Sigma-Aldrich	792373	2-Chloro-2,2-difluoroacetophenone 95%	384-67-8	1g	$63.2	2023-06-20	Buy
TRC	C423215	2-Chloro-2,2-difluoroacetophenone	384-67-8	100mg	$60	2021-12-16	Buy
TRC	C423215	2-Chloro-2,2-difluoroacetophenone	384-67-8	500mg	$75	2021-12-16	Buy
Biosynth Carbosynth	FD30535	2,2-Difluoro-2-chloroacetophenone	384-67-8	2g	$76	2021-12-16	Buy

Product number	Packaging	Price	Buy
792373	10g	$308	Buy
792373	1g	$63.2	Buy
C423215	100mg	$60	Buy
C423215	500mg	$75	Buy
FD30535	2g	$76	Buy

2-CHLORO-2,2-DIFLUOROACETOPHENONE Chemical Properties,Uses,Production

Description

Novel and non-ODS-based (ODS = ozone-depleting substance) difluorocarbene reagents for O- and N-difluoromethylation. PhCOCF2Cl reacts with a variety of structurally diverse phenol derivatives to produce aryl difluoromethyl ethers in good yields. PhSO2CF2Cl can react with a variety of structurally diverse phenol derivatives and N-heterocyclic compounds.

Uses

2-Chloro-2,2-difluoroacetophenone can be used:

As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.

General Description

2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem?-difluoromethene derived compounds.

reaction suitability

reaction type: C-C Bond Formation

2-CHLORO-2,2-DIFLUOROACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

Ethanone, 2,2-difluoro-2-(methylthio)-1-phenyl- (9CI) 4-(Difluoromethoxy)-2-fluorobromobenzene

2-CHLORO-2,2-DIFLUOROACETOPHENONE Suppliers

Global( 132)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29734	60
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30229	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14360	58
Unipharm pharmaceutical industry Co., Ltd	536-8266195 +8613953676784	lee@unipharm-sd.com	China	1202	58
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9629	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Fluoropharm Co., Ltd.	60
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Win-Win chemical CO., Limited	58
Unipharm pharmaceutical industry Co., Ltd	58
Finetech Industry Limited	58

View Lastest Price from 2-CHLORO-2,2-DIFLUOROACETOPHENONE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2022-02-22	2-Chloro-2,2-difluoroacetophenone 384-67-8	US $0.00 / KG	1KG	97.8%	100 tons	Honest Joy Holdings Limited

2-Chloro-2,2-difluoroacetophenone
384-67-8
US $0.00 / KG
97.8%
Honest Joy Holdings Limited

384-67-8(2-CHLORO-2,2-DIFLUOROACETOPHENONE)Related Search:

Difluorochloromethane N-tert-Butyldimethylsilyl-2-[S-(fluoromethyl)sulfonimidoyl]pyridine, 98% 16-HEXADECANOLIDE Iodine monochloride 1-Chloropinacolone

2-CHLORO-2',5'-DIFLUOROACETOPHENONE,2-CHLORO-2,5-DIFLUOROACETOPHENONE 2-CHLORO-2,2-DIFLUOROACETOPHENONE 2,2-DIFLUOROACETOPHENONE 2'-FLUOROACETOPHENONE Phenethyl chloride

1-Chloro-1,1-difluoroethane 2-Chloro-2',4'-difluoroacetophenone 2'-CHLORO-4',5'-DIFLUOROACETOPHENONE,2-CHLORO-4,5-DIFLUOROACETOPHENONE 3'-CHLORO-2',6'-DIFLUOROACETOPHENONE 2-Chloro-3',4'-difluoroacetophenone

4'-Chloro-2',5'-difluoroacetophenone 97%,4-CHLORO-2,5-DIFLUOROACETOPHENONE,4'-CHLORO-2',5'-DIFLUOROACETOPHENONE,4'-Chloro-2',5'-difluoroacetophenone97% 4'-CHLORO-2',6'-DIFLUOROACETOPHENONE A-CHLORO-2',4'-DIFLUOROACETOPHENONE

1of4

CHLORODIFLUOROACETOPHENONE alpha,alpha-Difluorophenacyl chloride 2-CHLORO-2,2-DIFLUOROACETOPHENONE A-CHLORO-A,A-DIFLUOROACETOPHENONE ALPHA-CHLORO-ALPHA,ALPHA-DIFLUOROACETOPHENONE ChlorodifluoroMethyl phenyl ketone 2-Chloro-2,2-d 2-chloro-2,2-difluoro-1-phenylethanone 2-chloro-2,2-difluoro-1-phenyl-ethanone 2-Chloro-2,2-difluoro-1-phenylethan-1-one à,à-difluorophenacyl chloride à-chloro-à,à-difluoroacetophene 2-Chloro-2,2-difluoroacetophenone 97% 2-Chloro-2,2-difluoroacetophenone97% 2-CHLORO-2,2-DIFLUOROACETOPHENE, 96% 1-Phenyl-2,2-difluoro-2-chloroethanone Phenyl(chlorodifluoromethyl) ketone α,α-Difluoro-α-chloroacetophenone Ethanone, 2-chloro-2,2-difluoro-1-phenyl- Chlorodifluorobenzophenone 384-67-8 C6H5COCF2Cl Fluorine series