2-Fluoro-5-methoxybenzoic acid
- CAS No.
- 367-83-9
- Chemical Name:
- 2-Fluoro-5-methoxybenzoic acid
- Synonyms
- BUTTPARK 45\01-62;RARECHEM AL BO 0748;2-Fluoro-5-methoxybenzoicaci;6-Fluoro-3-methoxybenzoic acid;2-Fluoro-5-methoxybenzoic acid;Benzoic acid, 2-fluoro-5-methoxy-;2-Fluoro-5-(methyloxy)benzoic acid;2-Fluoro-5-Methoxybenzoic acid, 97+%;3-Carboxy-4-fluoroanisole, 6-Fluoro-m-anisic acid
- CBNumber:
- CB7141401
- Molecular Formula:
- C8H7FO3
- Molecular Weight:
- 170.14
- MDL Number:
- MFCD00272566
- MOL File:
- 367-83-9.mol
- MSDS File:
- SDS
| Melting point | 146-150 |
|---|---|
| Boiling point | 302.7±22.0 °C(Predicted) |
| Density | 1.307 |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 3.15±0.10(Predicted) |
| Appearance | White to off-white Solid |
| CAS DataBase Reference | 367-83-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-36 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2918999090 | |||||||||
| NFPA 704 |
|
2-Fluoro-5-methoxybenzoic acid price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC8208 | 2-Fluoro-5-methoxybenzoic acid ≥95% | 367-83-9 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC8208 | 2-Fluoro-5-methoxybenzoic acid ≥95% | 367-83-9 | 1g | $28 | 2026-06-04 | Buy |
| Apolloscientific | PC8208 | 2-Fluoro-5-methoxybenzoic acid ≥95% | 367-83-9 | 5g | $40 | 2026-06-04 | Buy |
| Activate Scientific | AS48237 | 2-Fluoro-5-methoxybenzoic acid 97% | 367-83-9 | 1g | $29 | 2026-06-04 | Buy |
| Activate Scientific | AS48237 | 2-Fluoro-5-methoxybenzoic acid 97% | 367-83-9 | 5g | $80 | 2026-06-04 | Buy |
2-Fluoro-5-methoxybenzoic acid Chemical Properties,Uses,Production
Chemical Properties
Class white powder
Uses
2-Fluoro-5-methoxybenzoic acid is used as an organic chemical synthesis intermediate.
Synthesis
459-60-9
124-38-9
367-83-9
The general procedure for the synthesis of 2-fluoro-5-methoxybenzoic acid from 4-fluoroanisole and carbon dioxide was as follows: 1-fluoro-4-methoxybenzene (5 g, 39.6 mmol, 1.0 eq.) and PMDTA (7.56 g, 43.62 mmol, 1.1 eq.) were dissolved in anhydrous THF (100 mL) under nitrogen protection and cooled to -60 °C. A solution of s-BuLi (1.3 M, 36.6 mL, 47.5 mmol, 1.2 eq.) was added slowly over 1 hr. The reaction mixture continued to be stirred at -60 °C for 2 hours. Subsequently, carbon dioxide gas was passed into the solution for 1 hour. After completion of the reaction, the mixture was slowly warmed to room temperature, acidified with 1 M HCl solution and extracted with EtOAc. The organic phases were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: EtOAc/petroleum ether, gradient from 0:1 to 1:1) to afford 2-fluoro-5-methoxybenzoic acid as a yellow solid (5.4 g, 80% yield).LC-MS: m/z 171.1 [M+H]+, 193.0 [M+Na]+. 1H NMR (400 MHz, DMSO-d6) δ. 13.33 (s, 1H), 7.31 (m, 1H), 7.24 (m, 1H), 7.20-7.16 (m, 1H), 3.78 (s, 3H).
References
[1] Journal of Organic Chemistry, 2007, vol. 72, # 4, p. 1271 - 1275
[2] Patent: WO2013/37705, 2013, A2. Location in patent: Page/Page column 61; 62
[3] Patent: WO2004/14856, 2004, A1. Location in patent: Page 21
[4] Tetrahedron Letters, 1992, vol. 33, # 49, p. 7495 - 7498
2-Fluoro-5-methoxybenzoic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Shanghai JONLN Reagent Co., Ltd. | 400-0066400 13621662912 | 422131432@qq.com | China | 9970 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Worldyang Chemical Co.,Ltd. | 021-56795766 | sales@worldyachem.com | China | 9475 | 58 |
View Lastest Price from 2-Fluoro-5-methoxybenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2021-07-13 | 2-FLUORO-5-METHOXYBENZOIC ACID
367-83-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-01-10 | 2-FLUORO-5-METHOXYBENZOIC ACID
367-83-9
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 2-FLUORO-5-METHOXYBENZOIC ACID
367-83-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-FLUORO-5-METHOXYBENZOIC ACID
367-83-9
- $1.00
- 99%
- Career Henan Chemical Co
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