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5-Bromo-2-chloro-4-methoxypyrimidine

5-Bromo-2-chloro-4-methoxypyrimidine structure

CAS No.: 57054-92-9

Chemical Name:: 5-Bromo-2-chloro-4-methoxypyrimidine

Synonyms: 5-BroMo-2-chloro-4-Methox...;5-Bromo-2-chloro-4-methoxypyrimidine;2-chloro-5-broMo-4-MethoxypyriMidine;Pyrimidine, 5-bromo-2-chloro-4-methoxy-;5-Bromo-2-chloro-4-methoxypyrimidine, >=98%;5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE ISO 9001：2015 REACH;5-Bromo-2-chloro-4-methoxy-1,3-diazine, 5-Bromo-2-chloropyrimidin-4-yl methyl ether

CBNumber:: CB7167984

Molecular Formula:: C5H4BrClN2O

Molecular Weight:: 223.46

MDL Number:: MFCD03001373

MOL File:: 57054-92-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:54:42

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5-Bromo-2-chloro-4-methoxypyrimidine Properties

Melting point	73-75 °C(Solv: hexane (110-54-3))
Boiling point	323.6±22.0 °C(Predicted)
Density	1.745±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml; Ethanol: 15 mg/ml
form	A crystalline solid
pka	-1.35±0.29(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H332-H335

Precautionary statements

P261-P280-P305+P351+P338

Hazard Codes

Hazard Note

Irritant

HS Code

2933599590

NFPA 704

	0
2		0

5-Bromo-2-chloro-4-methoxypyrimidine price More Price(56)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21862	5-bromo-2-chloro-4-Methoxypyrimidine ≥98%	57054-92-9	5g	$33	2026-04-30	Buy
Cayman Chemical	21862	5-bromo-2-chloro-4-Methoxypyrimidine ≥98%	57054-92-9	10g	$60	2026-04-30	Buy
Cayman Chemical	21862	5-bromo-2-chloro-4-Methoxypyrimidine ≥98%	57054-92-9	25g	$131	2026-04-30	Buy
Cayman Chemical	21862	5-bromo-2-chloro-4-Methoxypyrimidine ≥98%	57054-92-9	10 g	$54	2024-03-01	Buy
Cayman Chemical	21862	5-bromo-2-chloro-4-Methoxypyrimidine ≥98%	57054-92-9	25 g	$119	2024-03-01	Buy

Product number	Packaging	Price	Buy
21862	5g	$33	Buy
21862	10g	$60	Buy
21862	25g	$131	Buy
21862	10 g	$54	Buy
21862	25 g	$119	Buy

5-Bromo-2-chloro-4-methoxypyrimidine Chemical Properties, Uses, Production

Description

5-bromo-2-chloro-4-Methoxypyrimidine is a building block used in the chemical synthesis of halogenated heterocycles.

Uses

5-Bromo-2-chloro-4-methoxypyrimidine is a building block in the chemical synthesis.

Synthesis

36082-50-5

124-41-4

57054-92-9

To a stirred solution of 5-bromo-2,4-dichloropyrimidine (500 mg, 2.19 mmol) in methanol (5 mL) was slowly added 30% sodium methanol solution (0.40 mL, 2.26 mmol). The reaction mixture was stirred at room temperature for 2 hours and then concentrated under reduced pressure. The residue was dissolved in water (5 mL) and extracted with ethyl acetate (3 x 5 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give 5-bromo-2-chloro-4-methoxypyrimidine (432 mg, 88% yield) as a white solid.LCMS-ESI (m/z): C5H4BrClN2O Calculated value: 223.4; Measured value: 224.2 [M + H]+, tR = 7.66 min (Method 2) The following is a summary of the results.

References

[1] Patent: WO2011/76419, 2011, A1. Location in patent: Page/Page column 119
[2] Patent: EP2338888, 2011, A1. Location in patent: Paragraph 0173; 0174
[3] Tetrahedron Letters, 2006, vol. 47, # 26, p. 4415 - 4418
[4] Patent: CN106588884, 2017, A. Location in patent: Paragraph 0299; 0303; 0304; 0305
[5] Patent: WO2013/90454, 2013, A2. Location in patent: Paragraph 00386

5-Bromo-2-chloro-4-methoxypyrimidine Preparation Products And Raw materials

Raw materials

5-Bromo-2,4-dichloropyrimidine Sodium Methanol Sodium Methoxide

Preparation Products

5-Bromo-2-iodo-4-methoxypyrimidine

5-Bromo-2-chloro-4-methoxypyrimidine Suppliers

Global Suppliers ( 103)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
China Langchem Inc.	0086-21-58956006		China	7798	57
Shanghai Sunway Pharmaceutical Technology Co., Ltd	13761987713	hxzheng@sunwaypharm.cn	China	8663	57
Shanghai Sphchem Co., Ltd.	021-56491756 13512199871	2819742715@qq.com	China	3994	55
Chengdu Forest Science and Technology Development Co., Ltd.	18030648795 18030648795	sales@cdforestchem.com	China	1998	58
Shanghai Topbiochem Technology Co., Ltd	+86-21-60341587	sales@topbiochem.com	China	6166	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Pure Chemistry Scientific Inc.	62
Accela ChemBio Co.,Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64
China Langchem Inc.	57
Shanghai Sunway Pharmaceutical Technology Co., Ltd	57
Shanghai Sphchem Co., Ltd.	55
Chengdu Forest Science and Technology Development Co., Ltd.	58
Shanghai Topbiochem Technology Co., Ltd	58

View Latest Price from 5-Bromo-2-chloro-4-methoxypyrimidine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-08-20	5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE 57054-92-9	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
	2019-12-20	5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE 57054-92-9	$1.00	1KG	99%	1000KGS	Career Henan Chemical Co

5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE
57054-92-9
$1.10
99.00%
Dideu Industries Group Limited

5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE
57054-92-9
$1.00
99%
Career Henan Chemical Co

5-Bromo-2-chloro-4-methoxypyrimidine Spectrum

5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE(57054-92-9)¹HNMR

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5-BroMo-2-chloro-4-Methox... Pyrimidine, 5-bromo-2-chloro-4-methoxy- 2-chloro-5-broMo-4-MethoxypyriMidine 5-Bromo-2-chloro-4-methoxy-1,3-diazine, 5-Bromo-2-chloropyrimidin-4-yl methyl ether 5-Bromo-2-chloro-4-methoxypyrimidine, >=98% 5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE ISO 9001：2015 REACH 5-Bromo-2-chloro-4-methoxypyrimidine 57054-92-9 Building Blocks Pyrimidine Heterocycle-Pyrimidine series