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5-Bromo-2,4-dichloropyrimidine

5-Bromo-2,4-dichloropyrimidine Structure
5-Bromo-2,4-dichloropyrimidine structure
CAS No.
36082-50-5
Chemical Name:
5-Bromo-2,4-dichloropyrimidine
Synonyms
NSC 152517;5-Bromo-2,4-dichL;BUTTPARK 48\06-22;TIMTEC-BB SBB003301;Xylose Impurity 3-d1;Palbociclib Impurity 99;2,4-Dichloro-5-Bromouracil;5-Bromo-2,4-dichloropyrdmidine;2,4-Dichloro-5-bormopyrimidine;5-BROMO-2,4-DICHLOROPYRIMIDINE
CBNumber:
CB2739049
Molecular Formula:
C4HBrCl2N2
Molecular Weight:
227.87
MDL Number:
MFCD00127818
MOL File:
36082-50-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-04 16:00:12
Product description Number Pack Size Price
5-Bromo-2,4-dichloropyrimidine 97% 416762 5g $114
5-Bromo-2,4-dichloropyrimidine 97% 416762 25g $153
5-Bromo-2,4-dichloropyrimidine >97.0%(GC) B2823 5g $22
5-Bromo-2,4-dichloropyrimidine >97.0%(GC) B2823 25g $63
2,4-Dichloro-5-bromopyrimidine D3530-50 10g $453
More product size
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5-Bromo-2,4-dichloropyrimidine Properties

Melting point 29-30 °C (lit.)
Boiling point 128 °C/15 mmHg (lit.)
Density 1.781 g/mL at 25 °C (lit.)
refractive index n20/D 1.603(lit.)
Flash point >230 °F
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly), Ether (Slightly), Ethyl Acetate (Slightly), Toluene (Slightly)
form Liquid or Low Melting Solid
pka -4.26±0.29(Predicted)
Specific Gravity 1.781
color Clear colorless to light yellow
BRN 124441
InChI InChI=1S/C4HBrCl2N2/c5-2-1-8-4(7)9-3(2)6/h1H
InChIKey SIKXIUWKPGWBBF-UHFFFAOYSA-N
SMILES C1(Cl)=NC=C(Br)C(Cl)=N1
CAS DataBase Reference 36082-50-5(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Skull and Crossbones (GHS06)
GHS05,GHS06
Signal word  Danger
Hazard statements  H301+H311+H331-H314-H317
Precautionary statements  P260-P280-P301+P310+P330-P301+P330+P331-P303+P361+P353-P305+P351+P338
PPE Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges
Hazard Codes  T,C
Risk Statements  23/24/25-34-43
Safety Statements  26-27-36/37/39-45
RIDADR  UN 3263 8/PG 2
WGK Germany  3
Hazard Note  Toxic/Corrosive
HazardClass  8
PackingGroup  III
HS Code  29335990
Storage Class 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
Hazard Classifications Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Eye Dam. 1
Skin Corr. 1B
Skin Sens. 1
REACH Registrations Active
Limited Quantities 1 Kg (2.2 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
0
3 0

5-Bromo-2,4-dichloropyrimidine price More Price(95)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 416762 5-Bromo-2,4-dichloropyrimidine 97% 36082-50-5 5g $114 2026-04-30 Buy
Sigma-Aldrich 416762 5-Bromo-2,4-dichloropyrimidine 97% 36082-50-5 25g $153 2026-04-30 Buy
TCI Chemical B2823 5-Bromo-2,4-dichloropyrimidine >97.0%(GC) 36082-50-5 5g $22 2026-04-30 Buy
TCI Chemical B2823 5-Bromo-2,4-dichloropyrimidine >97.0%(GC) 36082-50-5 25g $63 2026-04-30 Buy
Usbiological D3530-50 2,4-Dichloro-5-bromopyrimidine 10g $453 2026-06-03 Buy
Product number Packaging Price Buy
416762 5g $114 Buy
416762 25g $153 Buy
B2823 5g $22 Buy
B2823 25g $63 Buy
D3530-50 10g $453 Buy

5-Bromo-2,4-dichloropyrimidine Chemical Properties,Uses,Production

Chemical Properties

Colourless Oil

Uses

Starting material for the synthesis of trisubstituted pyrimidines via a combination of nucleophilic substitution and palladium-catalyzed aryl cross-coupling.1

Uses

5-Bromo-2,4-dichloropyrimidine may be employed as starting reagent for the synthesis of positive allosteric modulators for GABAB receptors (drug-like class of compounds) and pyridinepyrimidine analogs.

General Description

5-Bromo-2,4-dichloropyrimidine is a halogenoprimidine. It has been reported as an intermediate during the synthesis of 2,4-di-t-butoxy-5-bromopyrimidine and 2,4-di-t-butoxy-5-pyrimidineboronic acid.

Synthesis

5-Bromouracil

51-20-7

5-Bromo-2,4-dichloropyrimidine

36082-50-5

General procedure for the synthesis of 5-bromo-2,4-dichloropyrimidine from 5-bromouracil: 5-bromouracil (6.0 g, 31.4 mmol) was placed in a reaction flask with phosphorus pentachloride (PCl5, 16.4 g, 87.9 mmol) and 1,1,2-trichloroethane (50 mL) was added as solvent. The reaction mixture was heated to reflux and the transformation of the mixture from suspension to a light yellow transparent solution was observed. The reaction progress was monitored by thin layer chromatography (TLC) and after confirming the complete conversion of the feedstock, the reaction mixture was cooled to room temperature. Subsequently, the reaction mixture was rapidly poured into stirred ice water and stirring was continued for 1 hour. The aqueous phase was extracted with dichloromethane (DCM, 3 x 50 mL), the organic layers were combined and dried with anhydrous magnesium sulfate (MgSO4). The solvent was removed by evaporation under reduced pressure to give a light yellow transparent liquid crude product. Finally, the crude product was purified by silica gel column chromatography to obtain the target compound 5-bromo-2,4-dichloropyrimidine as a colorless transparent liquid (99.5% yield, 97% purity).

References

[1] Patent: CN108117523, 2018, A. Location in patent: Paragraph 0039; 0041; 0043; 0044; 0045
[2] Purinergic Signalling, 2017, vol. 13, # 1, p. 89 - 103
[3] Patent: CN105237483, 2016, A. Location in patent: Paragraph 0039; 0040; 0041; 0042; 0043
[4] Patent: US4299961, 1981, A
[5] Journal of the American Chemical Society, 1934, vol. 56, p. 134,138

5-Bromo-2,4-dichloropyrimidine synthesis

51-20-7
36082-50-5
Synthesis of 5-Bromo-2,4-dichloropyrimidine from 5-Bromouracil

5-Bromo-2,4-dichloropyrimidine Preparation Products And Raw materials

Raw materials

5-Bromouracil Phosphorus pentachloride 1,1,2-Trichloroethane

Preparation Products

4-Amino-5-bromo-2-chloropyrimidine 4-BENZYLOXY-5-BROMO-2-CHLOROPYRIMIDINE 2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE 5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE 2 , 4-BIS(BENZYLOXY)-5-BROMOPYRIMIDINE
5-BROMO-2-CHLORO-4-(DIMETHYLAMINO)PYRIMIDINE 2,4-DI-(TERT-BUTOXY)-5-BROMOPYRIMIDINE 5-Bromo-2-chloro-4-methylpyrimidine 5-Bromo-2-chloro-N-phenyl-4-pyrimidinamine 5-bromo-2-chloro-N-(prop-2-en-1-yl)pyrimidin-4-amine
5-Bromo-2,4-bis(methylthio)pyrimidine 5-BROMO-2-CHLORO-4-(1-PIPERIDINYL)PYRIMIDINE cyclobutanecarboxylic acid [3-(5-bromo-2-chloro-pyrimidin-4-ylamino)-propyl]-amide (5-BroMo-2-chloro-pyriMidin-4-yl)-Methyl-aMine 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine

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5-Bromo-2,4-dichloropyrimidine Suppliers

Global( 605)Suppliers
Supplier Tel Email Country ProdList Advantage
Chemsigma International Co., Ltd.
+86-2558742998 +86-19951791336 info@chemsigma.com China 1823 58
AstaTech(Chengdu) Biopharmaceutical Corp.
+86-02882666559 +86-15884417729 gjpu@astatech.com.cn China 308 58
Changzhou Jiuwu Chemical co., Ltd.
+86-0519-85121086 info@jiuwuchem.cn China 77 58
Lianhe Aigen Pharmatech Co.,Ltd.
+86-18918657159; +86-18918657159 sales@lianhe-aigen.com China 300 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20111 58
Frapp's ChemicalNFTZ Co., Ltd. 		+86 (576) 8169-6106 sales@frappschem.com China 877 50
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14034 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1796 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21531 55
Supplier Advantage
Chemsigma International Co., Ltd.
58
AstaTech(Chengdu) Biopharmaceutical Corp.
58
Changzhou Jiuwu Chemical co., Ltd.
58
Lianhe Aigen Pharmatech Co.,Ltd.
58
Henan Fengda Chemical Co., Ltd 		58
Frapp's ChemicalNFTZ Co., Ltd. 		50
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55

Related articles

View Lastest Price from 5-Bromo-2,4-dichloropyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-Bromo-2,4-dichloropyrimidine pictures 2026-08-17 5-Bromo-2,4-dichloropyrimidine
36082-50-5
 $5.00 1KG 98% Henan Fengda Chemical Co., Ltd
5-Bromo-2,4-dichloropyrimidine pictures 2026-06-30 5-Bromo-2,4-dichloropyrimidine
36082-50-5
 1KG 99.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
5-Bromo-2,4-dichloropyrimidine pictures 2025-04-04 5-Bromo-2,4-dichloropyrimidine
36082-50-5
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

5-Bromo-2,4-dichloropyrimidine Spectrum

5-Bromo-2,4-dichloropyrimidine(36082-50-5)1HNMR5-Bromo-2,4-dichloropyrimidine(36082-50-5)FT-IR

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BUTTPARK 48\06-22 5-BROMO-2,4-DICHLOROPYRIMIDINE TIMTEC-BB SBB003301 5-Bromo-2,4-Dichloropyridimidine 5-BROMO-2,4-DICHLOROPYRIMIDINE 99% 2,4-DICHLORO-5-BROMO PYRIMIDINE 5-Bromo-2,4-dichL 5-Bromo-2,4-dichloropyrimidine ,97% 5-Bromo-2,4-dichloropyrimidine,98% 2,4-Dichloro-5-bormopyrimidine 5-Bromo-2,4-dichloropyrdmidine 2,4-Dichloro-5-broMopyriMidine See B684030 5-BroMo-2,6-dichloropyriMidine NSC 152517 5-BroMo-2,4-dichloropyriMidine See D433775 2,6-Dichloro-5-broMopyriMidine 5-Bromo-2,4-dichloro-1,3-diazine 5-broMo -2,4-two chloropyriMidine Pyrimidine, 5-bromo-2,4-dichloro- 5 - broMine - 2, 4 - dichloro pyriMidine 5-Bromo-2,4-dichloropyrimidine > Palbociclib Impurity 99 5-Bromo-2,4-dichloropyrimidine,36082-50-5 2,4-Dichloro-5-Bromouracil 5-Bromo-2,4-dichloropyrimidine (98.65%) 5-Bromo-2,4-Dichlor Pyrimidine Xylose Impurity 3-d1 5-Bromo-2,4-dichloropyrimidine, 98% min. purity 36082-50-5 30682-50-5 366082-50-5 36082-50-7 C4HBrCl2N2 C4HBrCI2N2 C4HN2BrCl2 Heterocyclic Building Blocks Halogenated Heterocycles Pyrimidines HALOGEN Building Blocks Building Blocks C4 to C5 Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks Heterocycle-Pyrimidine series Heterocyclic Building Blocks Pyrimidines PyrimidinesHeterocyclic Building Blocks pharmacetical Halides Pyrazines, Pyrimidines & Pyridazines Pyrimidine Pyrimidine Series Pyridines, Pyrimidines, Purines and Pteredines Halogenated Organohalides Nucleotides and Nucleosides