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2-(Trifluoromethyl)pyridine

2-(Trifluoromethyl)pyridine structure

CAS No.: 368-48-9

Chemical Name:: 2-(Trifluoromethyl)pyridine

Synonyms: 2-(CF3)-Pyridine;α,α,α-trifluoro-2-picoline;à,à,à-trifluoro-2-picoline;2-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 2-(trifluoromethyl)-;2-(TrifluoroMethyl)pyridine, 95+%;2-trifluoromethylpyridine UNDRE RD;ALPHA,ALPHA,ALPHA-TRIFLUORO-2-PICOLINE;2-(Trifluoromethyl)pyridine ISO 9001：2015 REACH;2-(Trifluoromethyl)pyridine,α,α,α-Trifluoro-2-picoline

CBNumber:: CB8727190

Molecular Formula:: C6H4F3N

Molecular Weight:: 147.1

MDL Number:: MFCD02183562

MOL File:: 368-48-9.mol

MSDS File:: SDS

Last updated:2026-05-28 05:18:14

Product description	Number	Pack Size	Price
2-(Trifluoromethyl)pyridine 97%	643572	1g	$22
2-(Trifluoromethyl)pyridine 97%	643572	5g	$58.7
2-(Trifluoromethyl)pyridine	T2683	1G	$20
2-(Trifluoromethyl)pyridine	T2683	5G	$76
2-TRIFLUOROMETHYL-PYRIDINE 97%	59946	5G	$30
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2-(Trifluoromethyl)pyridine Properties

Boiling point	139-141 °C
Density	1.275 g/mL at 25 °C
refractive index	n20/D 1.419
Flash point	109 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in most organic solvents.
pka	0.60±0.12(Predicted)
form	clear liquid
color	Colorless to Light yellow
BRN	3112
InChI	InChI=1S/C6H4F3N/c7-6(8,9)5-3-1-2-4-10-5/h1-4H
InChIKey	ATRQECRSCHYSNP-UHFFFAOYSA-N
SMILES	C1(C(F)(F)F)=NC=CC=C1
CAS DataBase Reference	368-48-9(CAS DataBase Reference)
NIST Chemistry Reference	2-(CF3)-pyridine(368-48-9)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Warning

Hazard statements

H226-H315-H319-H335

Precautionary statements

P210-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xi,F

Risk Statements

10-36/37/38

Safety Statements

16-26-36

RIDADR

UN 1993 3/PG 3

WGK Germany

Hazard Note

Flammable/Irritant

HazardClass

PackingGroup

III

HS Code

2933399990

Storage Class

3 - Flammable liquids

Hazard Classifications

Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3

Limited Quantities

5.0 L (1.3 gallons) (liquid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	2
2		0

2-(Trifluoromethyl)pyridine price More Price(62)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	643572	2-(Trifluoromethyl)pyridine 97%	368-48-9	1g	$22	2023-06-20	Buy
Sigma-Aldrich	643572	2-(Trifluoromethyl)pyridine 97%	368-48-9	5g	$58.7	2023-06-20	Buy
TCI Chemical	T2683	2-(Trifluoromethyl)pyridine	368-48-9	1G	$20	2026-04-30	Buy
TCI Chemical	T2683	2-(Trifluoromethyl)pyridine	368-48-9	5G	$76	2026-04-30	Buy
AstaTech	59946	2-TRIFLUOROMETHYL-PYRIDINE 97%	368-48-9	5G	$30	2026-04-30	Buy

Product number	Packaging	Price	Buy
643572	1g	$22	Buy
643572	5g	$58.7	Buy
T2683	1G	$20	Buy
T2683	5G	$76	Buy
59946	5G	$30	Buy

2-(Trifluoromethyl)pyridine Chemical Properties,Uses,Production

Uses

Lithiation with n-BuLi/LiOCH2CH2NMe2takes place at the 6-position, affording access to 6-substituted derivatives. With LiTMP. It is a building block in heterocycle synthesis.

Synthesis Reference(s)

Synthesis, p. 932, 1980 DOI: 10.1055/s-1980-29276

Synthesis

109-04-6

81290-20-2

368-48-9

AgF (1.27 g, 10 mmol) was dissolved in 10 mL of DMF at room temperature and stirred thoroughly. Subsequently, Me3SiCF3 (1.7 g, 12 mmol) was added to the mixture and stirring was continued for 20 minutes. Next, copper powder (1.0 g, 15 mmol) was added and the reaction mixture was stirred for 4 hours to ensure complete formation of CuCF3. Then, the corresponding halogenated compound (9 mmol, 4.5 mmol for 2,6-dibromopyridine) was added and the reaction mixture continued to be stirred under the conditions listed in Table 1. The progress of the reaction was monitored by 19F NMR spectroscopy until the signal of CuCF3 completely disappeared and the reaction was terminated. Upon completion of the reaction, the mixture was filtered to remove the solid precipitate and the filtrate was poured into 50 mL of water. The organic layer in the aqueous phase was extracted with ether and the extract was dried with MgSO4. Finally, the ether was removed by evaporation and the residue was purified by distillation under reduced pressure or crystallization to give the target product 2-trifluoromethylpyridine.

References

[1] Journal of Fluorine Chemistry, 2012, vol. 133, p. 67 - 71

2-(Trifluoromethyl)pyridine synthesis

Synthesis of 2-(Trifluoromethyl)pyridine from 2-Bromopyridine and S-(Trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate

2-(Trifluoromethyl)pyridine Preparation Products And Raw materials

Raw materials

2-Iodopyridine 2-Bromopyridine S-(Trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate (Trifluoromethyl)trimethylsilane Trifluoromethyl iodide

ZINC Silver fluoride Copper N,N-Dimethylformamide

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Preparation Products

2-(Trifluoromethyl)isonicotinic acid 2-(TRIFLUOROMETHYL)-4-ISOCYANATOPYRIDINE 6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione 4-(Trifluoromethyl)pyridine 2-Trifluoromethyl-6-pyridinecarboxylic acid

2-(Trifluoromethyl)pyridine Suppliers

Global( 232)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	FandaChem@Gmail.com	China	1445	55
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	615	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20120	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58

Supplier	Advantage
Hangzhou FandaChem Co.,Ltd.	55
Nantong Guangyuan Chemicl Co,Ltd	58
Henan Fengda Chemical Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 2-(Trifluoromethyl)pyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-09	2-(Trifluoromethyl)pyridine 368-48-9	$1.50-32.00	1kg	99%		Henan Fengda Chemical Co., Ltd
2025-11-18	2-(Trifluoromethyl)pyridine 368-48-9	$1.10	1g	99.00%	100 Tons min	Dideu Industries Group Limited
2025-04-04	2-(Trifluoromethyl)pyridine 368-48-9		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

2-(Trifluoromethyl)pyridine
368-48-9
$1.50-32.00
99%
Henan Fengda Chemical Co., Ltd

2-(Trifluoromethyl)pyridine
368-48-9
$1.10
99.00%
Dideu Industries Group Limited

2-(Trifluoromethyl)pyridine
368-48-9
98%
Henan Aochuang Chemical Co.,Ltd.

2-(Trifluoromethyl)pyridine Spectrum

2-(Trifluoromethyl)pyridine(368-48-9)¹HNMR

368-48-9(2-(Trifluoromethyl)pyridine)Related Search:

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4-(Trifluoromethyl)pyridine 7-CHLORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE 3-BROMO-5-(TRIFLUOROMETHYL)PYRIDINE 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE 2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE

2-CHLORO-6-(TRIFLUOROMETHYL)PYRIDINE 2,8-Bis(trifluoromethyl)-4-quinolinol 3,4-BIS(TRIFLUOROMETHYL)PYRIDINE

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Pyridine, 2-(trifluoromethyl)- ALPHA,ALPHA,ALPHA-TRIFLUORO-2-PICOLINE à,à,à-trifluoro-2-picoline α,α,α-trifluoro-2-picoline 2-(TRIFLUOROMETHYL)PYRIDINE 2-(Trifluoromethyl)pyridine,α,α,α-Trifluoro-2-picoline 2-trifluoromethylpyridine UNDRE RD 2-(CF3)-Pyridine 2-(TrifluoroMethyl)pyridine, 95+% 2-(Trifluoromethyl)pyridine ISO 9001：2015 REACH 368-48-9 135490-18-8 241557-68-8 Pyridines Heterocyclic Building Blocks Building Blocks C6 Fluorine series pharmacetical Pyridines Pyridine