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BOC-SER(ME)-OH

BOC-SER(ME)-OH Structure
BOC-SER(ME)-OH structure
CAS No.
51293-47-1
Chemical Name:
BOC-SER(ME)-OH
Synonyms
BOC-O-METHYL-L-SERINE;BOC-SER(ME)-OH;BOC-L-Ser（Me）-OH;Boc-O-Methyl-L-Se;BOC-O-METHYL-L-SER;BOC-SER(ME)-OH DCHA;BOC-SERINE(ME)-OH DCHA;N-Boc-O-methyl-L-serine;BOC-L-SERINE(METHYL ETHER);BOC-O-METHYL-L-SERINE DCHA
CBNumber:
CB7218147
Molecular Formula:
C9H17NO5
Molecular Weight:
219.24
MDL Number:
MFCD00153314
MOL File:
51293-47-1.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:47
Product description Number Pack Size Price
Boc-Ser(Me)-OH B673128 250mg $50
N-Boc-O-methyl-L-serine 95+% ee AS29499 1g $52
Boc-O-methyl-L-serinedicyclohexylammoniumsalt,≥98.5%(HPLC) ≥98.5%(HPLC) 05599 1G $58.24
(2S)-2-Amino-3-methoxypropanoic acid, N-Boc protected 4158-1-S7 1g $63
(2S)-2-Amino-3-methoxypropanoicacid,N-BOCprotected OR307095 1g $29
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BOC-SER(ME)-OH Properties

Boiling point 355.8±37.0 °C(Predicted)
Density 1.148±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
form solid
pka 3.52±0.10(Predicted)
color Yellow-brown
InChI InChI=1S/C9H17NO5/c1-9(2,3)15-8(13)10-6(5-14-4)7(11)12/h6H,5H2,1-4H3,(H,10,13)(H,11,12)/t6-/m0/s1
InChIKey RFGMSGRWQUMJIR-LURJTMIESA-N
SMILES C(O)(=O)[C@H](COC)NC(OC(C)(C)C)=O
CAS DataBase Reference 51293-47-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HazardClass  IRRITANT
HS Code  2924297099
NFPA 704
1
0 0

BOC-SER(ME)-OH price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B673128 Boc-Ser(Me)-OH 51293-47-1 250mg $50 2021-12-16 Buy
Activate Scientific AS29499 N-Boc-O-methyl-L-serine 95+% ee 51293-47-1 1g $52 2021-12-16 Buy
Chem-Impex 05599 Boc-O-methyl-L-serinedicyclohexylammoniumsalt,≥98.5%(HPLC) ≥98.5%(HPLC) 51293-47-1 1G $58.24 2021-12-16 Buy
SynQuest Laboratories 4158-1-S7 (2S)-2-Amino-3-methoxypropanoic acid, N-Boc protected 51293-47-1 1g $63 2021-12-16 Buy
Apolloscientific OR307095 (2S)-2-Amino-3-methoxypropanoicacid,N-BOCprotected 51293-47-1 1g $29 2021-12-16 Buy
Product number Packaging Price Buy
B673128 250mg $50 Buy
AS29499 1g $52 Buy
05599 1G $58.24 Buy
4158-1-S7 1g $63 Buy
OR307095 1g $29 Buy

BOC-SER(ME)-OH Chemical Properties,Uses,Production

Chemical Properties

White to off-white crystals

Uses

BOC-SER(ME)-OH, also known as Boc-Ser-OMe or N-tert-butyloxycarbonyl-L-serine methyl ester, is an amino acid derivative commonly used in peptide synthesis.

Synthesis

O-methylserine

4219-94-7

Di-tert-butyl dicarbonate

24424-99-5

BOC-SER(ME)-OH

51293-47-1

General procedure for the synthesis of N-Boc-O-methyl-L-serine from O-methyl DL-serine and di-tert-butyl dicarbonate: 35 mL of aqueous 1 N sodium hydroxide solution and 35 mL of tetrahydrofuran (THF) were added to 2.0 g (17 mmol) of O-methyl DL-serine. With stirring at 0 °C, a solution of di-tert-butyl dicarbonate (4.03 g, 18.5 mmol) in THF (15 mL) was added slowly. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction mixture was concentrated by evaporation under reduced pressure. The aqueous phase was acidified to pH 4-5 with 10% aqueous citric acid and then extracted with ethyl acetate. The organic phase was washed with saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give 3.6 g of N-Boc-O-methyl-L-serine (98% yield). Mass spectrum (ESI) m/z: 220.1 (M + H)+.

References

[1] Chemistry - A European Journal, 2011, vol. 17, # 15, p. 4183 - 4194
[2] Patent: WO2016/11088, 2016, A2. Location in patent: Paragraph 00238; 00239

BOC-SER(ME)-OH synthesis

75-18-3
3262-72-4
51293-47-1
Synthesis of BOC-SER(ME)-OH from Dimethyl sulfide and BOC-L-Serine

BOC-SER(ME)-OH Preparation Products And Raw materials

Raw materials

L-?Serine, N-?[(1,?1-?dimethylethoxy)?carbonyl]?-?O-?methyl-?, phenylmethyl ester L-Serine, N-[(1,1-diMethylethoxy)carbonyl]-O-Methyl-, Methyl ester L-Serine, N-[(1,1-diMethylethoxy)carbonyl]-O-Methyl-, coMpd. with N-cyclohexylcyclohexanaMine (1:1) Boc-L-serine methyl ester BOC-L-Serine
Di-tert-butyl dicarbonate Iodomethane tert-butyl azidoformate O-methylserine Dimethyl sulfide

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Preparation Products

Carbamic acid, [(1R)-2-hydroxy-1-(methoxymethyl)ethyl]-, 1,1-dimethylethyl

BOC-SER(ME)-OH Suppliers

Global( 229)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13815 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21592 55
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
GenicBio Limited 		+86-21-37621270 service@genicbio.com CHINA 991 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29826 58
Sichuan Jiaying Lai Technology Co.,LTD 		18716376478 ycling@enlaibio.com CHINA 302 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Shanghai Yingrui Biopharma Co.,Ltd 		21-33585366 export01@shyrchem.com CHINA 1319 58
Supplier Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Yingrui Biopharma Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
GenicBio Limited 		58
career henan chemical co 		58
Sichuan Jiaying Lai Technology Co.,LTD 		58
BOC Sciences 		58
Alchem Pharmtech,Inc. 		58
Shanghai Yingrui Biopharma Co.,Ltd 		58

View Lastest Price from BOC-SER(ME)-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Boc-ser(me)-OH pictures 2020-01-06 Boc-ser(me)-OH
51293-47-1
 US $1.00 / g 1g 98% 100KG Sichuan Jiaying Lai Technology Co.,LTD
BOC-SER(ME)-OH pictures 2019-07-06 BOC-SER(ME)-OH
51293-47-1
 US $100.00 / KG 1KG 99% Customized Career Henan Chemical Co
  • Boc-ser(me)-OH pictures
  • Boc-ser(me)-OH
    51293-47-1
  • US $1.00 / g
  • 98%
  • Sichuan Jiaying Lai Technology Co.,LTD

BOC-SER(ME)-OH Spectrum

BOC-SER(ME)-OH(51293-47-1)1HNMR

51293-47-1(BOC-SER(ME)-OH)Related Search:

Boc-Ser(tBu)-OH (dicyclohexylammonium) salt,Boc-Ser(tBu)-OH Dicyclohexylamine Salt,Boc-Ser(Tbu)-Ohcha,Boc-Ser(tBu)-OH•,BOC-SER(TBU)-OH DCHA BOC-SER(ME)-OH Boc-O-tert-butyl-L-threonine Boc-Ser(tBu)-OH 3-FLUORO-5-(TRIFLUOROMETHYL)PHENOL
Boc-Thr(Bzl)-OH (S)-(-)-3-TERT-BUTOXYCARBONYL-4-METHOXYCARBONYL-2,2-DIMETHYL-1,3-OXAZOLIDINE BOC-THR(ME)-OH BOC-Ser (Obzl) OH,BOC-SER(BUT)-OH,BOC-SER(BU)-OH,BOC-SER(TBU)-OH BOC-SER(BU)-OH,BOC-SER(BUT)-OH,BOC-SER(TBU)-OH
Boc-D-Ser(Bzl)-OH BOC-L-Serine L-Serine BOC-SER(BZL)-OH DCHA BOC-L-THR(ALLOC)-OH DCHA
BOC-SER(BZL)-OSU BOC-O-BENZYL-L-THREONINE N-CARBOXY ANHYDRIDE Boc-Ser(Aloc)-OH·DCHA

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BOC-L-Ser（Me）-OH (2S)-2-(tert-Butoxycarbonylamino)-3-methoxy-propanoic acid (S)-N-BOC-2-AMINO-3-METHOXY-PROPIONIC ACID N-ALPHA-T-BUTOXYCARBONYL-O-METHYL-L-SERINE N-ALPHA-T-BUTOXYCARBONYL-O-METHYL-L-SERINE DICYCLOHEXYLAMMONIUM SALT N-ALPHA-T-BOC-O-METHYL-L-SERINE BOC-(S)-2-AMINO-3-METHOXYLPROPANOIC ACID BOC-(S)-2-AMINO-3-METHOXYPROPIONIC ACID BOC-SER(ME)-OH BOC-SER(ME)-OH DCHA BOC-SERINE(ME)-OH DCHA Boc-O-methyl-L-serine dicyclohexylammonium salt≥ 98.5% (HPLC) BOC-L-SERINE(METHYL ETHER) BOC-O-METHYL-L-SER BOC-O-METHYL-L-SERINE BOC-O-METHYL-L-SERINE DCHA BOC-O-METHYL-L-SERINE DICYCLOHEXYLAMMONIUM SALT Boc-O-methyl-L-Serinedicyclohexylamine salt Boc-O-Methyl-L-Se N-tert-Butoxycarbonyl-O-methyl-L-serine (S)-2-(tert-butoxycarbonylamino)-3-methoxypropanoicacid L-Serine, N-[(1,1-diMethylethoxy)carbonyl]-O-Methyl- Boc-Ser(Me)-OH·DCHA Boc-O-Methyl-L-SerinedicyclohexylaMine salt N-Boc-O-Methyl-L-serine, 97% (2S)-2-Amino-3-methoxypropanoic acid, N-BOC protected N-Boc-O-methyl-L-serine,97% (S)-N-Boc-2-Amino-3-Methoxy-PropionicAci N-α-(t-Butoxycarbonyl)-O-methyl-L-serine N-tert-butoxycarbonyl-(S)-O-methyl-serin N-[(1,1-Dimethylethoxy)carbonyl]-O-methyl-L-serine (2S)-3-methoxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid N-Boc-O-methyl-L-serine 51293-47-1 C9H17NO5C12H23N unnatural amino acids Boc-Amino acid series Serine [Ser, S] Boc-Amino Acids and Derivative API