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Boc-Ser(Me)-OH

Boc-Ser(Me)-OH Structure
Boc-Ser(Me)-OH structure
CAS No.
51293-47-1
Chemical Name:
Boc-Ser(Me)-OH
Synonyms
BOC-O-METHYL-L-SERINE;Boc-Ser(Me)-OH;BOC-L-Ser（Me）-OH;Boc-O-Methyl-L-Se;HRBSM/Boc-Ser(me);BOC-O-METHYL-L-SER;BOC-SER(ME)-OH DCHA;BOC-SERINE(ME)-OH DCHA;N-Boc-O-methyl-L-serine;BOC-L-SERINE(METHYL ETHER)
CBNumber:
CB7218147
Molecular Formula:
C9H17NO5
Molecular Weight:
219.24
MDL Number:
MFCD00153314
MOL File:
51293-47-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:54:45
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Boc-Ser(Me)-OH Properties

Boiling point 355.8±37.0 °C(Predicted)
Density 1.148±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
form solid
pka 3.52±0.10(Predicted)
color Yellow-brown
InChI InChI=1S/C9H17NO5/c1-9(2,3)15-8(13)10-6(5-14-4)7(11)12/h6H,5H2,1-4H3,(H,10,13)(H,11,12)/t6-/m0/s1
InChIKey RFGMSGRWQUMJIR-LURJTMIESA-N
SMILES C(O)(=O)[C@H](COC)NC(OC(C)(C)C)=O
CAS DataBase Reference 51293-47-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HazardClass  IRRITANT
HS Code  2924297099
NFPA 704
1
0 0

Boc-Ser(Me)-OH price More Price(81)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 263738 Boc-Ser(Me)-OH 51293-47-1 100g $1692 2026-06-03 Buy
Usbiological 263738 Boc-Ser(Me)-OH 51293-47-1 250g $3186 2026-06-03 Buy
Usbiological 263738 Boc-Ser(Me)-OH 51293-47-1 500g $4962 2026-06-03 Buy
Usbiological 263738 Boc-Ser(Me)-OH 51293-47-1 1kg $7568 2026-06-03 Buy
Usbiological 263738 Boc-Ser(Me)-OH 51293-47-1 2kg $13499 2026-06-03 Buy
Product number Packaging Price Buy
263738 100g $1692 Buy
263738 250g $3186 Buy
263738 500g $4962 Buy
263738 1kg $7568 Buy
263738 2kg $13499 Buy

Boc-Ser(Me)-OH Chemical Properties, Uses, Production

Chemical Properties

White to off-white crystals

Uses

BOC-SER(ME)-OH, also known as Boc-Ser-OMe or N-tert-butyloxycarbonyl-L-serine methyl ester, is an amino acid derivative commonly used in peptide synthesis.

Synthesis

O-methylserine

4219-94-7

Di-tert-butyl dicarbonate

24424-99-5

BOC-SER(ME)-OH

51293-47-1

General procedure for the synthesis of N-Boc-O-methyl-L-serine from O-methyl DL-serine and di-tert-butyl dicarbonate: 35 mL of aqueous 1 N sodium hydroxide solution and 35 mL of tetrahydrofuran (THF) were added to 2.0 g (17 mmol) of O-methyl DL-serine. With stirring at 0 °C, a solution of di-tert-butyl dicarbonate (4.03 g, 18.5 mmol) in THF (15 mL) was added slowly. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction mixture was concentrated by evaporation under reduced pressure. The aqueous phase was acidified to pH 4-5 with 10% aqueous citric acid and then extracted with ethyl acetate. The organic phase was washed with saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give 3.6 g of N-Boc-O-methyl-L-serine (98% yield). Mass spectrum (ESI) m/z: 220.1 (M + H)+.

References

[1] Chemistry - A European Journal, 2011, vol. 17, # 15, p. 4183 - 4194
[2] Patent: WO2016/11088, 2016, A2. Location in patent: Paragraph 00238; 00239

Boc-Ser(Me)-OH synthesis

75-18-3
3262-72-4
51293-47-1
Synthesis of Boc-Ser(Me)-OH from Dimethyl sulfide and BOC-L-Serine

Boc-Ser(Me)-OH Preparation Products And Raw materials

Raw materials

L-?Serine, N-?[(1,?1-?dimethylethoxy)?carbonyl]?-?O-?methyl-?, phenylmethyl ester L-Serine, N-[(1,1-diMethylethoxy)carbonyl]-O-Methyl-, Methyl ester L-Serine, N-[(1,1-diMethylethoxy)carbonyl]-O-Methyl-, coMpd. with N-cyclohexylcyclohexanaMine (1:1) Boc-L-serine methyl ester BOC-L-Serine
Di-tert-butyl dicarbonate Iodomethane tert-butyl azidoformate O-methylserine Dimethyl sulfide

1of2

Preparation Products

Carbamic acid, [(1R)-2-hydroxy-1-(methoxymethyl)ethyl]-, 1,1-dimethylethyl

Boc-Ser(Me)-OH Suppliers

Global Suppliers ( 232)
Supplier Tel Email Country ProdList Advantage
Sichuan jiayinglai technology CO.,LTD 9018 15982359653 1394531348@qq.com China 2271 55
Chengdu Dorher Pharmaceutical CO.,Ltd 028-64259743 19983537320 wangmin@focuspharm.com China 498 58
Chengdu Chuangkecheng Biological Technology Co., Ltd. 028-028-0000000 13008177686 sales@ckcbiotech.com China 899 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Supplier Advantage
Sichuan jiayinglai technology CO.,LTD 55
Chengdu Dorher Pharmaceutical CO.,Ltd 58
Chengdu Chuangkecheng Biological Technology Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Chembest Research Laboratories Limited 61
Alfa Aesar 84
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
GL Biochem (Shanghai) Ltd 64
Jia Xing Isenchem Co.,Ltd 66

View Latest Price from Boc-Ser(Me)-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Boc-ser(me)-OH pictures 2020-01-06 Boc-ser(me)-OH
51293-47-1
 $1.00 1g 98% 100KG Sichuan Jiaying Lai Technology Co.,LTD
BOC-SER(ME)-OH pictures 2019-07-06 BOC-SER(ME)-OH
51293-47-1
 $100.00 1KG 99% Career Henan Chemical Co
  • Boc-ser(me)-OH pictures
  • Boc-ser(me)-OH
    51293-47-1
  • $1.00
  • 98%
  • Sichuan Jiaying Lai Technology Co.,LTD

Boc-Ser(Me)-OH Spectrum

BOC-SER(ME)-OH(51293-47-1)1HNMR

51293-47-1 (Boc-Ser(Me)-OH) Related Search:

Boc-O-tert-butyl-L-threonine Boc-Ser(tBu)-OH (dicyclohexylammonium) salt,Boc-Ser(tBu)-OH Dicyclohexylamine Salt,Boc-Ser(Tbu)-Ohcha,Boc-Ser(tBu)-OH•,BOC-SER(TBU)-OH DCHA Boc-Thr(Bzl)-OH BOC-Ser (Obzl) OH,BOC-SER(BUT)-OH,BOC-SER(BU)-OH,BOC-SER(TBU)-OH Boc-O-tert-butyl-L-serine
L-Serine BOC-L-Serine Boc-D-Ser(Bzl)-OH Boc-Thr(Me)-OH 3-Fluoro-5-(trifluoromethyl)phenol
Boc-O-benzyl-L-homoserine Boc-Ser(Me)-OH (S)-(-)-3-tert-Butoxycarbonyl-4-methoxycarbonyl-2,2-dimethyl-1,3-oxazolidine Bpoc-Ser(tBu)-OH cha Boc-Thr(Bzl)-OSu
Boc-O-benzyl-L-serine N-carboxy anhydride Boc-allo-Thr(tBu)-OH dcha Boc-L-Thr(Alloc)-OH dcha

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BOC-L-Ser（Me）-OH (2S)-2-(tert-Butoxycarbonylamino)-3-methoxy-propanoic acid (S)-N-BOC-2-AMINO-3-METHOXY-PROPIONIC ACID N-ALPHA-T-BUTOXYCARBONYL-O-METHYL-L-SERINE N-ALPHA-T-BUTOXYCARBONYL-O-METHYL-L-SERINE DICYCLOHEXYLAMMONIUM SALT N-ALPHA-T-BOC-O-METHYL-L-SERINE BOC-(S)-2-AMINO-3-METHOXYLPROPANOIC ACID BOC-(S)-2-AMINO-3-METHOXYPROPIONIC ACID BOC-SER(ME)-OH DCHA BOC-SERINE(ME)-OH DCHA Boc-O-methyl-L-serine dicyclohexylammonium salt≥ 98.5% (HPLC) BOC-L-SERINE(METHYL ETHER) BOC-O-METHYL-L-SER BOC-O-METHYL-L-SERINE DCHA BOC-O-METHYL-L-SERINE DICYCLOHEXYLAMMONIUM SALT Boc-O-methyl-L-Serinedicyclohexylamine salt Boc-O-Methyl-L-Se N-tert-Butoxycarbonyl-O-methyl-L-serine (S)-2-(tert-butoxycarbonylamino)-3-methoxypropanoicacid L-Serine, N-[(1,1-diMethylethoxy)carbonyl]-O-Methyl- Boc-Ser(Me)-OH·DCHA Boc-O-Methyl-L-SerinedicyclohexylaMine salt N-Boc-O-Methyl-L-serine, 97% (2S)-2-Amino-3-methoxypropanoic acid, N-BOC protected N-Boc-O-methyl-L-serine,97% (S)-N-Boc-2-Amino-3-Methoxy-PropionicAci N-α-(t-Butoxycarbonyl)-O-methyl-L-serine N-tert-butoxycarbonyl-(S)-O-methyl-serin N-[(1,1-Dimethylethoxy)carbonyl]-O-methyl-L-serine (2S)-3-methoxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid N-Boc-O-methyl-L-serine BOC-O-METHYL-L-SERINE HRBSM/Boc-Ser(me) Boc-Ser(Me)-OH 51293-47-1 C9H17NO5C12H23N unnatural amino acids Boc-Amino acid series Serine [Ser, S] Boc-Amino Acids and Derivative API