Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Palonosetron

Palonosetron

Palonosetron Structure
Palonosetron structure
CAS No.
135729-56-5
Chemical Name:
Palonosetron
Synonyms
PALMATINE(P);RS 25233-198;Palonosteron;Unii-5D06587D6r;(S)-2-(1-Azabicyclo[2.2.2]oct-3-yl)-2,4,5,6-tetrahydro-1H-benz[de]isoquinolin-1-one;1H-Benz[de]isoquinolin-1-one, 2-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,4,5,6-tetrahydro-;(3AS)-2-(S)-1-AZABICYCLO[2,2,2]OCT-3-YL)-2,3,3A,4,5,6-HEXAHYDRO-1H-BENZ(D)ISOQUINOLIN-1-ONE;(3AS)-2-[(3S)-1-AZABICYCLO[2.2.2]OCT-3-YL]-2,3,3A,4,5,6-HEXAHYDRO-1H-BENZ[DE]ISOQUINOLIN-1-ONE;Palonosetron (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one
CBNumber:
CB7257940
Molecular Formula:
C19H22N2O
Molecular Weight:
294.39
MDL Number:
MFCD07783848
MOL File:
135729-56-5.mol
TDS File:
TDS
Last updated:2026-05-20 15:45:26
Request For Quotation

Palonosetron Properties

Boiling point 511.0±50.0 °C(Predicted)
Density 1.24
pka 9.77±0.33(Predicted)
FDA UNII 29WVV1OJ05

Palonosetron Chemical Properties, Uses, Production

Uses

Palonosetron can be used to Anti-emetic; antinauseant.

brand name

Aloxi (Helsinn).

in vivo

In anesthetized rats, Dehydro Palonosetron (RS 42358-197), administered by the intravenous, intraduodenal or transdermal route, dose-dependently inhibited the Bezold-Jarisch reflex induced by 2-methyl 5-HT (ID50:0.05 μg/kg; i.v., 5.7 μg/kg; i.d., and 11.6 μg/chamber, respectively)[1].
Dehydro Palonosetron (RS 42358-197; 0.01 ng/kg-10 mg/kg; oral administration; once) disinhibits behaviour in the mouse suppressed by the aversive situation of the light/dark test box[2].

Animal Model:Male albino BKW mice (30-35 g)[2]
Dosage:0.01 ng/kg, 0.1 ng/kg, 1 ng/kg, 100 ng/kg, 1 μg/kg, 100 μg/kg, 1 mg/kg, 10 mg/kg
Administration: Oral administration; once
Result:Increased the proportion of time mice spent and the number of rearings and line crossings in the light area of the test chamber.

IC 50

5-HT3 Receptor

Palonosetron synthesis

135729-78-1
135729-56-5
Synthesis of Palonosetron from (S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide

Palonosetron Preparation Products And Raw materials

Raw materials

1-Naphthalenecarboxamide, N,N-diethyl-8-formyl-5,6,7,8-tetrahydro- 5,6,7,8-Tetrahydro-naphthalene-1-carbonyl chloride 5,6,7,8-Tetrahydronaphthalene-1-carboxylic acid (S)-quinuclidin-3-aMine N,N-Diethyl-5,6,7,8-tetrahydronaphthalene-1-carboxamide
(S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide 5,6-Dihydro-1H,4H-naphtho[1,8-cd]pyran-1-one

1of2

Preparation Products

Palonosetron Suppliers

Global Suppliers ( 55)
Supplier Tel Email Country ProdList Advantage
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 7909 65
Shanghai Holy Biohemdeviser Co., Ltd 021-61551100 China 443 57
Chengdu DingDang Pharmaceutical Co., Ltd. 028-86040038 market@dingdangchem.com China 1853 55
Roark Standards 0755-83552066 15986688328 service@roarkstandards.com China 1442 58
Amatek Scientific Co. Ltd. 0512-56316828 400-867-5858;400-867-5858 info@amateksci.com China 28760 58
Jinan Yaoyan Pharmaceutical Co., Ltd. jnyaoyan@163.com China 3057 58
Henan Alfachem Co.,Ltd. 0371-55051623 18137891487 3983243027@qq.com China 9974 58
Alchemist-pharm chemical Technology Co. Ltd. 0371-67991738 13783628208 carl@alchemist-pharm.com China 1867 58
Shenzhen Botel Biotechnology Co. Ltd. 13316949107 13316968096 1979313431@qq.com China 9619 58
TOSUN PHARM 020-66392521-118 18922260391 3004261881@qq.com China 7994 58
Supplier Advantage
Daicel Chiral Technologies (China)CO.,LTD 65
Shanghai Holy Biohemdeviser Co., Ltd 57
Chengdu DingDang Pharmaceutical Co., Ltd. 55
Roark Standards 58
Amatek Scientific Co. Ltd. 58
Jinan Yaoyan Pharmaceutical Co., Ltd. 58
Henan Alfachem Co.,Ltd. 58
Alchemist-pharm chemical Technology Co. Ltd. 58
Shenzhen Botel Biotechnology Co. Ltd. 58
TOSUN PHARM 58

View Latest Price from Palonosetron manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Palonosetron pictures 2020-02-01 Palonosetron
135729-56-5
 $1.00 1KG 98% 200kgs Career Henan Chemical Co

135729-56-5 (Palonosetron) Related Search:

Tropisetron Palmatine Palmatine chloride PALMATINE CHLORIDE HYDRATE Palonosetron
Palonosetron Hydrochloride (S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide N-Methyl-N-(4-piperidinylmethyl)-acetamide N-Methyl-N-(phenylmethyl)-4-piperidinemethanamine 2-(piperidin-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline
Palmatine chloride std.,PALMATINE CHLORIDE(RG) PALMATINE(P) N-Methyl-N-(4-piperidinylmethyl)-benzamide N-Methyl-N-(2-phenylethyl)-4-piperidinemethanamine (S)-(S)-2-(1-Aza-bicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-benzo[de]isoquinolin-1-one
1,8-Dimethyltetraline PALMATINE IODIDE PALMATINE CHLORID

1of4

Palonosteron RS 25233-198 PALMATINE(P) (3AS)-2-(S)-1-AZABICYCLO[2,2,2]OCT-3-YL)-2,3,3A,4,5,6-HEXAHYDRO-1H-BENZ(D)ISOQUINOLIN-1-ONE (S)-2-(1-Azabicyclo[2.2.2]oct-3-yl)-2,4,5,6-tetrahydro-1H-benz[de]isoquinolin-1-one Unii-5D06587D6r Palonosetron (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one (3AS)-2-[(3S)-1-AZABICYCLO[2.2.2]OCT-3-YL]-2,3,3A,4,5,6-HEXAHYDRO-1H-BENZ[DE]ISOQUINOLIN-1-ONE 1H-Benz[de]isoquinolin-1-one, 2-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,4,5,6-tetrahydro- 135729-56-5