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7-BROMO-4-METHOXYINDOLE

7-BROMO-4-METHOXYINDOLE Structure
7-BROMO-4-METHOXYINDOLE structure
CAS No.
81224-16-0
Chemical Name:
7-BROMO-4-METHOXYINDOLE
Synonyms
7-BROMO-4-METHOXYINDOLE;bromo-7 methoxy-4 indole;1H-Indole, 7-broMo-4-Methoxy-
CBNumber:
CB7263107
Molecular Formula:
C9H8BrNO
Molecular Weight:
226.07
MDL Number:
MFCD04037872
MOL File:
81224-16-0.mol
MSDS File:
SDS
Last updated:2026-05-28 05:13:58
Product description Number Pack Size Price
7-Bromo-4-methoxy-1H-indole 312275 250.00mg $73
7-Bromo-4-methoxy-1H-indole 312275 1.00g $222
7-Bromo-4-methoxy-1H-indole 312275 5.00g $678
7-Bromo-4-methoxyindole 009814 250.00mg $71
7-Bromo-4-methoxyindole 009814 1.00g $218
Request For Quotation

7-BROMO-4-METHOXYINDOLE Properties

storage temp. 2-8°C
Appearance Off-white to light brown Solid
InChI InChI=1S/C9H8BrNO/c1-12-8-3-2-7(10)9-6(8)4-5-11-9/h2-5,11H,1H3
InChIKey WWKHWWGUJPWWDF-UHFFFAOYSA-N
SMILES N1C2=C(C(OC)=CC=C2Br)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H317
Precautionary statements  P280
Hazard Codes  Xi
HazardClass  IRRITANT

7-BROMO-4-METHOXYINDOLE price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 312275 7-Bromo-4-methoxy-1H-indole 81224-16-0 250.00mg $73 2026-05-19 Buy
Matrix Scientific 312275 7-Bromo-4-methoxy-1H-indole 81224-16-0 1.00g $222 2026-05-19 Buy
Matrix Scientific 312275 7-Bromo-4-methoxy-1H-indole 81224-16-0 5.00g $678 2026-05-19 Buy
Matrix Scientific 009814 7-Bromo-4-methoxyindole 81224-16-0 250.00mg $71 2026-05-18 Buy
Matrix Scientific 009814 7-Bromo-4-methoxyindole 81224-16-0 1.00g $218 2026-05-18 Buy
Product number Packaging Price Buy
312275 250.00mg $73 Buy
312275 1.00g $222 Buy
312275 5.00g $678 Buy
009814 250.00mg $71 Buy
009814 1.00g $218 Buy

7-BROMO-4-METHOXYINDOLE Chemical Properties,Uses,Production

Synthesis

2-BROMO-5-METHOXYANILINE

59557-92-5

Chloroacetonitrile

107-14-2

1,2-Dichloroethane

107-06-2

7-BROMO-4-METHOXYINDOLE

81224-16-0

(a) Synthesis of 4-methoxy-7-bromoindole. 2-Bromo-5-methoxyaniline (4.4 g, 21.8 mmol) was slowly added dropwise to a dichloromethane solution of boron trichloride (1.0 M, 24 mL, 24 mmol) cooled in an ice-water bath. The reaction mixture was gradually warmed to room temperature with continuous stirring for 30 minutes. Subsequently, chloroacetonitrile (4.01 mL, 26.2 mmol), aluminum chloride (4.01 g, 24.0 mmol) and 1,2-dichloroethane (28.5 mL) were added sequentially. The reaction system was heated to 70 °C to evaporate the dichloromethane and then warmed to reflux for 24 hours. Upon completion of the reaction, it was cooled to 0-5 °C and 2.5 M HCl (38.4 mL) was slowly added, followed by heating to 80 °C for 1 h until the solid was completely dissolved. The aqueous phase was separated, the organic phase was extracted with dichloromethane, the organic layers were combined, washed with water and saturated saline in turn, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give a yellow solid crude product, which was used directly in the next reaction. The above crude product was dissolved in a solvent mixture of dioxane (37 mL) and water (4.2 mL), and sodium borohydride (0.91 g, 24.0 mmol) was added in batches. After stirring for 30 minutes at room temperature to confirm complete consumption of the ingredients, the reaction was heated to reflux for 14 hours. The reaction solution was cooled to room temperature, acidified with concentrated HCl and extracted with ethyl acetate. The organic phase was washed with water and saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to afford 4-methoxy-7-bromoindole (1.2 g, 24% yield).1H NMR (400 MHz, CDCl3) δ 3.94 (s, 3H), 6.44 (d, J = 8.21 Hz, 1H), 6.73 (m, 1H), 7.17 (t, J = 2.74 Hz, 1H), 7.22-7H). 1H), 7.22-7.26 (m, 1H), 8.32 (br, 1H); MS (ES, m/z): C9H8BrNO: 227.99 (M+ (79Br)+1), 230.0 (M+ (81Br)+1).

References

[1] Patent: US2004/48915, 2004, A1

7-BROMO-4-METHOXYINDOLE synthesis

81224-15-9
81224-16-0
Synthesis of 7-BROMO-4-METHOXYINDOLE from 1H-Indole-2-carboxylic acid, 7-bromo-4-methoxy-

7-BROMO-4-METHOXYINDOLE Preparation Products And Raw materials

Raw materials

2-BROMO-5-METHOXYANILINE 1H-Indole-2-carboxylic acid, 7-bromo-4-methoxy- Vinylmagnesium bromide 4-Bromo-3-nitroanisole Boron trichloride
Chloroacetonitrile Water 1,2-Dichloroethane Hydrochloric acid Dichloromethane

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Preparation Products

7-BROMO-4-METHOXYINDOLE Suppliers

Global( 66)Suppliers
Supplier Tel Email Country ProdList Advantage
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
KARMEL TECHNOLOGY (HK) CO.,LIMITED 		+8618795957998 karmelhk@126.com CHINA 2886 58
CR Corporation Limited 		+8613062833949 fred.wen@crcorporation.cn China 8645 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19987 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
DAYANG CHEM (HANGZHOU) CO.,LTD 		+86-88938639 +86-17705817739 info@dycnchem.com China 53803 58
NANJING YINGWEN BIOTECHNOLOGY CO LTD 		+8613382787392 sales@aeechem.com China 10002 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131956 58
Supplier Advantage
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
KARMEL TECHNOLOGY (HK) CO.,LIMITED 		58
CR Corporation Limited 		58
Labnetwork lnc. 		58
Aladdin Scientific 		58
DAYANG CHEM (HANGZHOU) CO.,LTD 		58
NANJING YINGWEN BIOTECHNOLOGY CO LTD 		58
Amadis Chemical Company Limited 		58

View Lastest Price from 7-BROMO-4-METHOXYINDOLE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
7-BROMO-4-METHOXYINDOLE pictures 2019-12-23 7-BROMO-4-METHOXYINDOLE
81224-16-0
 $1.00 1KG 99% 100KG Career Henan Chemical Co

7-BROMO-4-METHOXYINDOLE Spectrum

7-BROMO-4-METHOXYINDOLE(81224-16-0)1HNMR

81224-16-0(7-BROMO-4-METHOXYINDOLE)Related Search:

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7-BROMO-4-METHOXYINDOLE 1H-Indole, 7-broMo-4-Methoxy- bromo-7 methoxy-4 indole 81224-16-0