7-BROMO-4-METHOXYINDOLE
- CAS No.
- 81224-16-0
- Chemical Name:
- 7-BROMO-4-METHOXYINDOLE
- Synonyms
- 7-BROMO-4-METHOXYINDOLE;bromo-7 methoxy-4 indole;1H-Indole, 7-broMo-4-Methoxy-
- CBNumber:
- CB7263107
- Molecular Formula:
- C9H8BrNO
- Molecular Weight:
- 226.07
- MDL Number:
- MFCD04037872
- MOL File:
- 81224-16-0.mol
- MSDS File:
- SDS
7-BROMO-4-METHOXYINDOLE price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B292900 | 7-Bromo-4-methoxy-1H-indole | 81224-16-0 | 100mg | $220 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB142289 | 7-Bromo-4-methoxyindole | 81224-16-0 | 100mg | $162 | 2021-12-16 | Buy |
| AK Scientific | 2615AC | 7-Bromo-4-methoxyindole | 81224-16-0 | 5g | $2723 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB142289 | 7-Bromo-4-methoxyindole | 81224-16-0 | 500mg | $565 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB142289 | 7-Bromo-4-methoxyindole | 81224-16-0 | 25mg | $53 | 2021-12-16 | Buy |
7-BROMO-4-METHOXYINDOLE Chemical Properties,Uses,Production
Synthesis
59557-92-5
107-14-2
107-06-2
81224-16-0
(a) Synthesis of 4-methoxy-7-bromoindole. 2-Bromo-5-methoxyaniline (4.4 g, 21.8 mmol) was slowly added dropwise to a dichloromethane solution of boron trichloride (1.0 M, 24 mL, 24 mmol) cooled in an ice-water bath. The reaction mixture was gradually warmed to room temperature with continuous stirring for 30 minutes. Subsequently, chloroacetonitrile (4.01 mL, 26.2 mmol), aluminum chloride (4.01 g, 24.0 mmol) and 1,2-dichloroethane (28.5 mL) were added sequentially. The reaction system was heated to 70 °C to evaporate the dichloromethane and then warmed to reflux for 24 hours. Upon completion of the reaction, it was cooled to 0-5 °C and 2.5 M HCl (38.4 mL) was slowly added, followed by heating to 80 °C for 1 h until the solid was completely dissolved. The aqueous phase was separated, the organic phase was extracted with dichloromethane, the organic layers were combined, washed with water and saturated saline in turn, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give a yellow solid crude product, which was used directly in the next reaction. The above crude product was dissolved in a solvent mixture of dioxane (37 mL) and water (4.2 mL), and sodium borohydride (0.91 g, 24.0 mmol) was added in batches. After stirring for 30 minutes at room temperature to confirm complete consumption of the ingredients, the reaction was heated to reflux for 14 hours. The reaction solution was cooled to room temperature, acidified with concentrated HCl and extracted with ethyl acetate. The organic phase was washed with water and saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to afford 4-methoxy-7-bromoindole (1.2 g, 24% yield).1H NMR (400 MHz, CDCl3) δ 3.94 (s, 3H), 6.44 (d, J = 8.21 Hz, 1H), 6.73 (m, 1H), 7.17 (t, J = 2.74 Hz, 1H), 7.22-7H). 1H), 7.22-7.26 (m, 1H), 8.32 (br, 1H); MS (ES, m/z): C9H8BrNO: 227.99 (M+ (79Br)+1), 230.0 (M+ (81Br)+1).
References
[1] Patent: US2004/48915, 2004, A1
7-BROMO-4-METHOXYINDOLE Preparation Products And Raw materials
7-BROMO-4-METHOXYINDOLE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29801 | 58 |
| KARMEL TECHNOLOGY (HK) CO.,LIMITED | +8618795957998 | karmelhk@126.com | CHINA | 2886 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8647 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53900 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai TuZhi Chemical Co., Ltd. | 19542790274 | 2119559397@qq.com | China | 1000 | 50 |
View Lastest Price from 7-BROMO-4-METHOXYINDOLE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-23 | 7-BROMO-4-METHOXYINDOLE
81224-16-0
|
US $1.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 7-BROMO-4-METHOXYINDOLE
81224-16-0
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
