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6,7-Dihydro-4(5H)-benzofuranone

6,7-Dihydro-4(5H)-benzofuranone structure

CAS No.: 16806-93-2

Chemical Name:: 6,7-Dihydro-4(5H)-benzofuranone

Synonyms: 6,7-dihydrobenzofuran-4(5H)-one;6,7-Dihydro-4(5H)-be;7-Dihydro-4(5H)-benzofuranone;6,7-DIHYDRO-4(5H)-BENZOFURANONE;2,3-Dihydro-4(5H)-benzofuranone;6,7-dihydro-5H-benzofuran-4-one;4(5H)-Benzofuranone,6,7-dihydro-;6,7-dihydro-5H-1-benzofuran-4-one;6,7-DIHYDRO-1-BENZOFURAN-4(5H)-ONE;4-oxo-4,5,6,7-tetrahydrobenzofuran

CBNumber:: CB7753154

Molecular Formula:: C8H8O2

Molecular Weight:: 136.15

MDL Number:: MFCD00215511

MOL File:: 16806-93-2.mol

MSDS File:: SDS

Last updated:2026-05-28 03:26:18

Product description	Number	Pack Size	Price
6,7-Dihydro-4(5H)-benzofuranone 98%	476773	5g	$149
4,5,6,7-Tetrahydro-1-benzofuran-4-one >99%	OR32842	5g	$21
4,5,6,7-Tetrahydro-1-benzofuran-4-one >99%	OR32842	25g	$85
4,5,6,7-Tetrahydro-1-benzofuran-4-one >99%	OR32842	100g	$332
4,5,6,7-Tetrahydro-1-benzofuran-4-one >99%	OR32842	500g	$1536
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6,7-Dihydro-4(5H)-benzofuranone Properties

Melting point	30-34 °C (lit.)
Boiling point	115-118 °C/16 mmHg (lit.)
Density	1.162 g/mL at 25 °C (lit.)
refractive index	1.53-1.532
Flash point	>230 °F
storage temp.	Sealed in dry,Store in freezer, under -20°C
form	Liquid
Specific Gravity	1.162
color	Clear yellow to brown
InChI	InChI=1S/C8H8O2/c9-7-2-1-3-8-6(7)4-5-10-8/h4-5H,1-3H2
InChIKey	DXWQOYPYNPSVRL-UHFFFAOYSA-N
SMILES	O1C2CCCC(=O)C=2C=C1
CAS DataBase Reference	16806-93-2(CAS DataBase Reference)
UNSPSC Code	12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
PPE	Eyeshields, Gloves, type N95 (US)
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	37/39-26
WGK Germany	3
HS Code	29143900
Storage Class	11 - Combustible Solids

6,7-Dihydro-4(5H)-benzofuranone price More Price(56)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	476773	6,7-Dihydro-4(5H)-benzofuranone 98%	16806-93-2	5g	$149	2023-06-20	Buy
Apolloscientific	OR32842	4,5,6,7-Tetrahydro-1-benzofuran-4-one >99%	16806-93-2	5g	$21	2026-06-04	Buy
Apolloscientific	OR32842	4,5,6,7-Tetrahydro-1-benzofuran-4-one >99%	16806-93-2	25g	$85	2026-06-04	Buy
Apolloscientific	OR32842	4,5,6,7-Tetrahydro-1-benzofuran-4-one >99%	16806-93-2	100g	$332	2026-06-04	Buy
Apolloscientific	OR32842	4,5,6,7-Tetrahydro-1-benzofuran-4-one >99%	16806-93-2	500g	$1536	2026-06-04	Buy

Product number	Packaging	Price	Buy
476773	5g	$149	Buy
OR32842	5g	$21	Buy
OR32842	25g	$85	Buy
OR32842	100g	$332	Buy
OR32842	500g	$1536	Buy

6,7-Dihydro-4(5H)-benzofuranone Chemical Properties,Uses,Production

Chemical Properties

clear yellow to brown low melting solid or liquid

Uses

6,7-Dihydro-4(5H)-benzofuranone may be used in the synthesis of furacridone ring skeleton.

Definition

ChEBI: 6,7-Dihydro-4(5H)-benzofuranone is a member of benzofurans.

Synthesis Reference(s)

Tetrahedron, 51, p. 3087, 1995 DOI: 10.1016/0040-4020(95)00070-O
Tetrahedron Letters, 27, p. 1127, 1986 DOI: 10.1016/S0040-4039(00)84195-7

General Description

6,7-Dihydro-4(5H)-benzofuranone is a benzofuran derivative that consists of fused benzene and furan ring. Its standard molar enthalpy of formation by static bomb calorimetry and standard molar enthalpy of vaporization using Calvet microcalorimetry has been measured. These values have been used to derive the standard molar enthalpy of formation in gaseous phase.

Synthesis

107-20-0

504-02-9

16806-93-2

Under argon protection, 1,3-cyclohexanedione (20.71 g, 0.18 mol) was dissolved in methanol (100 mL) and the solution was cooled to 0 °C. Subsequently, potassium hydroxide (12.2 g, 0.18 mol) was added to the solution and stirred continuously for 30 minutes at 0 °C. Next, 50% aqueous chloroacetaldehyde solution (26.3 mL, 0.203 mol) was slowly added. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the solution was acidified to pH < 7 with 1N hydrochloric acid and then extracted with ethyl acetate. The organic layers were combined, washed sequentially with water and saturated saline, and dried over anhydrous magnesium sulfate. Finally, the solvent was removed by concentration under reduced pressure to give the crude 6,7-dihydro-4(5H)-benzofuranone product (16.5 g), which was pure enough to be used directly in the next step of the reaction.

References

[1] Arkivoc, 2011, vol. 2011, # 9, p. 1 - 14
[2] Heterocycles, 2004, vol. 62, p. 807 - 813
[3] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 4, p. 1966 - 1982
[4] Journal of Organic Chemistry, 1988, vol. 53, # 17, p. 4135 - 4137
[5] Chemical and Pharmaceutical Bulletin, 1994, vol. 42, # 10, p. 2167 - 2169

6,7-Dihydro-4(5H)-benzofuranone synthesis

Synthesis of 6,7-Dihydro-4(5H)-benzofuranone from Chloroacetaldehyde and 1,3-Cyclohexanedione

6,7-Dihydro-4(5H)-benzofuranone Preparation Products And Raw materials

Raw materials

1,3-Cyclohexanedione, 2-diazo- 2-Furanbutanoyl chloride 4(2H)-Benzofuranone, 3,5,6,7-tetrahydro-3-hydroxy- 3-hydroxycyclohex-2-en-1-one Chloroacetaldehyde

1,4-Dimethoxybenzene Potassium hydroxide Methanol VINYLIDENE CHLORIDE 1,3-Cyclohexanedione

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Preparation Products

Methyl 4-Oxo-4,5,6,7-Tetrahydrobenzofuran-5-Carboxylate

6,7-Dihydro-4(5H)-benzofuranone Suppliers

Global( 170)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5228	58
Springchem New Material Technology Co.,Limited	+86-021-62885108 +8613917661608	info@spring-chem.com	China	2068	57
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Shaanxi Dideu Medichem Co. Ltd	+8617392709771	1097@dideu.com	China	3992	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	9542	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10236	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co,.LTD	58
Springchem New Material Technology Co.,Limited	57
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Alchem Pharmtech,Inc.	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
Zhengzhou Alfa Chemical Co.,Ltd	58
Hubei Ipure Biology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from 6,7-Dihydro-4(5H)-benzofuranone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-28	6,7-Dihydro-4(5H)-benzofuranone 16806-93-2	$9.00	1KG	99.8%	100tons	Hebei Chuanghai Biotechnology Co,.LTD
2026-05-05	6,7-Dihydro-4(5H)-benzofuranone 16806-93-2	$80.00-800.00	10kg	0.99	20tons	Zibo Hangyu Biotechnology Development Co., Ltd
2025-12-24	6,7-Dihydro-4(5H)-benzofuranone 16806-93-2	$980.00	1KG	98%	1T	Shaanxi Dideu Medichem Co. Ltd

6,7-Dihydro-4(5H)-benzofuranone
16806-93-2
$9.00
99.8%
Hebei Chuanghai Biotechnology Co,.LTD

6,7-Dihydro-4(5H)-benzofuranone
16806-93-2
$80.00-800.00
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

6,7-Dihydro-4(5H)-benzofuranone
16806-93-2
$980.00
98%
Shaanxi Dideu Medichem Co. Ltd

6,7-Dihydro-4(5H)-benzofuranone Spectrum

6,7-Dihydro-4(5H)-benzofuranone(16806-93-2)¹HNMR 6,7-Dihydro-4(5H)-benzofuranone(16806-93-2)IR

16806-93-2(6,7-Dihydro-4(5H)-benzofuranone)Related Search:

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Dibenzofuran POLY(TETRAHYDROFURAN) STANDARD 15000 4-OXO-4,5,6,7-TETRAHYDROBENZO[B]FURAN-3-CARBOXYLIC ACID 6,6-DIMETHYL-6,7-DIHYDRO-1-BENZOFURAN-4(5H)-ONE 3-ACETYL-2,6,6-TRIMETHYL-5,6,7-TRIHYDROOXAINDEN-4-ONE

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6,7-DIHYDRO-1-BENZOFURAN-4(5H)-ONE 6,7-DIHYDRO-4(5H)-BENZOFURANONE 6,7-Dihydro-4(5H)-benzofuranone, GC 98% 6,7-DIHYDRO-4(5H)-BENZOFURANONE 98% 6,7-Dihydro-4(5H)-benzofuranone,98% 2,3-Dihydro-4(5H)-benzofuranone 6,7-Dihydro-4(5H)-be 3,4-dihydro-2H-cyclopenta[b]pyran-5-one 4-oxo-4,5,6,7-tetrahydrobenzofuran 6,7-dihydro-5H-1-benzofuran-4-one 4(5H)-Benzofuranone,6,7-dihydro- 4,?5,?6,?7-?TETRAHYDRO-?4-?OXOBENZO[B]?FURAN 7-Dihydro-4(5H)-benzofuranone 6,7-dihydro-5H-benzofuran-4-one 6,7-Dihydro-4(5H)-benzofuranone 6,7-dihydrobenzofuran-4(5H)-one 16806-93-2 16906-93-2 KETONE Heterocyclic Building Blocks Benzofurans Building Blocks Benzofurans Building Blocks Heterocyclic Building Blocks