Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>3,4-Dihydroquinolin-2(1H)-one

3,4-Dihydroquinolin-2(1H)-one

3,4-Dihydroquinolin-2(1H)-one Structure
3,4-Dihydroquinolin-2(1H)-one structure
CAS No.
553-03-7
Chemical Name:
3,4-Dihydroquinolin-2(1H)-one
Synonyms
HYDROCARBOSTYRIL;3,4-DIHYDRO-1H-QUINOLIN-2-ONE;3,4-DIHYDRO-2(1H)-QUINOLINONE;3,4-Dihydro-2-quinolinone;1,2,3,4-Tetrahydroquinolin-2-one;2-OXO-1,2,3,4-TETRAHYDROQUINOLINE;inone;DIHYDROCARBOSTYRIL;dihydro-α-quinolone;3,4-Dihydrocarbostyril
CBNumber:
CB5772351
Molecular Formula:
C9H9NO
Molecular Weight:
147.17
MDL Number:
MFCD00016722
MOL File:
553-03-7.mol
MSDS File:
SDS
Last updated:2026-09-12 18:53:41
Request For Quotation

3,4-Dihydroquinolin-2(1H)-one Properties

Melting point 165-167 °C (lit.)
Boiling point 267.28°C (rough estimate)
Density 1.1135 (rough estimate)
refractive index 1.5200 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
form Crystalline Powder
pka 14.76±0.20(Predicted)
color Off-white
Water Solubility Slightly soluble in water.
Sensitive Light Sensitive
Merck 13,4800
InChI InChI=1S/C9H9NO/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-4H,5-6H2,(H,10,11)
InChIKey TZOYXRMEFDYWDQ-UHFFFAOYSA-N
SMILES N1C2=C(C=CC=C2)CCC1=O
CAS DataBase Reference 553-03-7(CAS DataBase Reference)
FDA UNII 2CKG6TX32F
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Skull and Crossbones (GHS06)
GHS07,GHS06
Signal word  Warning
Hazard statements  H301-H302-H315-H317-H319-H335
Precautionary statements  P280a-P301+P310a-P405-P501a-P261-P280-P305+P351+P338
target organs Respiratory system
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38-43
Safety Statements  26-36/37
RIDADR  2811
WGK Germany  2
Hazard Note  Irritant
HazardClass  6.1(b)
PackingGroup  III
HS Code  29337900
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
STOT SE 3
NFPA 704
0
2 0

3,4-Dihydroquinolin-2(1H)-one price More Price(71)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 415936 3,4-Dihydro-2(1H)-quinolinone 98% 553-03-7 10g $171 2023-06-20 Buy
Sigma-Aldrich 415936 3,4-Dihydro-2(1H)-quinolinone 98% 553-03-7 1g $39.4 2023-01-07 Buy
Cayman Chemical 31701 3,4-Dihydroquinolin-2(1H)-one ≥98% 553-03-7 1g $40 2026-04-30 Buy
Cayman Chemical 31701 3,4-Dihydroquinolin-2(1H)-one ≥98% 553-03-7 5g $132 2026-04-30 Buy
Cayman Chemical 31701 3,4-Dihydroquinolin-2(1H)-one ≥98% 553-03-7 10g $246 2026-04-30 Buy
Product number Packaging Price Buy
415936 10g $171 Buy
415936 1g $39.4 Buy
31701 1g $40 Buy
31701 5g $132 Buy
31701 10g $246 Buy

3,4-Dihydroquinolin-2(1H)-one Chemical Properties,Uses,Production

Chemical Properties

Off-white crystalline powder

Uses

3,4-Dihydro-2-(1H)-quinolinone may be employed as medium supplement in the culture medium of Pseudomonas ayucida during enrichment culture experiments. It is used to prepare potent bicyclic peptide deformylase inhibitors with antibacterial effects. It is also used to synthesize substituted iminopiperidines as inhibitors of human nitric oxide synthase isoforms.

Uses

3,4-Dihydro-2(1H)-quinolinone may be employed as medium supplement in the culture medium of Pseudomonas ayucida during enrichment culture experiments.

Definition

ChEBI: 3,4-Dihydro-2(1H)-quinolinone is a member of quinolines.

Synthesis Reference(s)

Journal of the American Chemical Society, 89, p. 7131, 1967 DOI: 10.1021/ja01002a061
Tetrahedron Letters, 36, p. 125, 1995 DOI: 10.1016/0040-4039(94)02191-D

General Description

Series of 3,4-dihydro-2(1H)-quinolinone derivatives having sigma-1 receptor (σ1R) antagonist activity have been synthesized. 3,4-dihydro-2((1)H)-quinolinones have been synthesized using N-(1′-alkoxy)cyclopropyl-2-haloanilines as starting reagent. Cyclopropane ring expansion in the presence of palladium catalyst is the major step involved in the synthesis. Library of 3,4-dihydro-2(1H)-quinolinones have been synthesized through the rearrangement of β-lactam intermediates on the solid-phase

3,4-Dihydroquinolin-2(1H)-one synthesis

83-33-0
553-03-7
Synthesis of 3,4-Dihydroquinolin-2(1H)-one from 1-Indanone

3,4-Dihydroquinolin-2(1H)-one Preparation Products And Raw materials

Raw materials

N-BOC-3,4-Dihydro-2(1H)-quinolinone 3-Chloro-N-phenylpropanamide 1-Indanone

Preparation Products

Cilostazol VESNARINONE 2-dioxaborolan-2-yl)quinolin-2(1H)-one 6,8-Dinitro-3,4-dihydro-1H-quinolin-2-one 6,8-Dichloro-3,4-dihydro-1H-quinolin-2-one
6,8-Dibromo-3,4-dihydroquinolin-2(1H)-one

1of2

3,4-Dihydroquinolin-2(1H)-one Suppliers

Global( 201)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Jingmen Pharmaceutical Industry Technology Research Institute Co., Ltd. 18186973118 359311405@qq.com China 153 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Bridge Organics +1269-649-4200 ab@bridgeorganics.com United States 160 55
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Supplier Advantage
Hubei Jingmen Pharmaceutical Industry Technology Research Institute Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Bridge Organics 55
TAIYUAN RHF CO.,LTD. 56
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60
Pure Chemistry Scientific Inc. 62
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64

View Lastest Price from 3,4-Dihydroquinolin-2(1H)-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,2,3,4-Tetrahydroquinolin-2-one pictures 2026-08-20 1,2,3,4-Tetrahydroquinolin-2-one
553-03-7
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited
1,2,3,4-Tetrahydroquinolin-2-one pictures 2021-10-15 1,2,3,4-Tetrahydroquinolin-2-one
553-03-7
 $10.00 1KG 99% 20 tons Hebei Zhanyao Biotechnology Co. Ltd
1,2,3,4-Tetrahydroquinolin-2-one pictures 2020-02-14 1,2,3,4-Tetrahydroquinolin-2-one
553-03-7
 $1.00 1KG 99% 200kgs Career Henan Chemical Co

3,4-Dihydroquinolin-2(1H)-one Spectrum

3,4-DIHYDROQUINOLIN-2(1H)-ONE(553-03-7)IR

553-03-7(3,4-Dihydroquinolin-2(1H)-one)Related Search:

Tetrahydro-4H-pyran-4-one Naringin dihydrochalcone Isoquinoline Quinhydrone 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
Epiandrosterone acetate Dehydroepiandrosterone Dihydromyrcenol Quinclorac 3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone
7-HYDROXY-1,2,3,4-TETRAHYDROQUINOLIN-2-ONE 3,4-Dihydroquinolin-2(1H)-one AURORA KA-3413 AURORA KA-6039 AURORA KA-5523
3-BENZYL-1-BUTYL-3-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE-2,4-DIONE AURORA KA-3185 1-Butyl-3-chloro-3-methyl-1,2,3,4-tetrahydroquinoline-2,4-dione

1of4

DIHYDROCARBOSTYRIL 3,4-DIHYDRO-2(H)-QUINOLINE 3,4-DIHYDRO-2(1H)-QUINOLONE 3,4-DIHYDRO-1H-QUINOLIN-2-ONE 2-OXO-1,3,4-TRIHYDROQUINOLINE dihydro-α-quinolone o-aminohydrocinnamic acid lactam 3,4-Dihydrocarbostyril 3,4-DIHYDRO-1H-QUINOLIN-2-ONE, 99+% 2-Oxo-1,2,3,4-tetrahydroquinoline, 3,4-Dihydrocarbostyril 3,4-Dihydroquinolin-2(1H)-one 97% 4-Dihydro-2(1H)-quinolinone 3,4-Dihydro-2-quinolone 1,2,3,4-Tetrahydro-2(1H)-quinolinone 1,2,3,4-Tetrahydro-2-oxoquinoline 1,2,3,4-Tetrahydroquinoline-2-one 3,4-Dihydro-2(1H)-quinolinone,98% 3,4-Dihydro-2(1H)-quinolinoneHydrocarbostyril 2(1H)-Quinolinone, 3,4-dihydro- 3,4-Dihydro-2(1H)-quinolinone, 97+% 3,4-Dihydro-2(1H)-quinolinone 98% 3,4-Dihydro-2(1H)-quinoL inone 1,2,3,4-Tetrahydroquinolin-2-one ISO 9001：2015 REACH 4-Tetrahydroquinolin-2-one 3,4-Dihydro-2(1H)-quinolinone 1,2,3,4-Tetrahydroquinolin-2-one 2-OXO-1,2,3,4-TETRAHYDROQUINOLINE 3,4-DIHYDRO-2(1H)-QUINOLINONE 3,4-Dihydro-2-quinolinone HYDROCARBOSTYRIL 3,4-Dihydroquinolin-2(1H)-one 553-03-7 C6H4CH2CH2CONH Building Blocks Quinolines Heterocyclic Building Blocks Quinolines, Isoquinolines & Quinoxalines Heterocycles pharmacetical API intermediates