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2-Acetyl-5-chlorothiophene

2-Acetyl-5-chlorothiophene Structure
2-Acetyl-5-chlorothiophene structure
CAS No.
6310-09-4
Chemical Name:
2-Acetyl-5-chlorothiophene
Synonyms
ba11044;BA 11044;AKOS 93296;2-Acetyl-5-chlorothi;2-Acetyl-5-chlorthiophen;Rivaroxaban Impurity 124;5-chlor-2-acetylthiophen;5-Chlor-2-acetyl thiophen;5-chloro-2-acetylthiophen;5-CHLORO-2-ACETYLTHIOPHENE
CBNumber:
CB7290079
Molecular Formula:
C6H5ClOS
Molecular Weight:
160.62
MDL Number:
MFCD00005444
MOL File:
6310-09-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:54:54
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2-Acetyl-5-chlorothiophene Properties

Melting point 46-49 °C (lit.)
Boiling point 117-118 °C/17 mmHg (lit.)
Density 1.3240 (estimate)
Flash point 227 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form Crystals or Crystalline Powder
color White to light yellow
Sensitive Light Sensitive
BRN 113936
InChI InChI=1S/C6H5ClOS/c1-4(8)5-2-3-6(7)9-5/h2-3H,1H3
InChIKey HTZGPEHWQCRXGZ-UHFFFAOYSA-N
SMILES C(=O)(C1SC(Cl)=CC=1)C
CAS DataBase Reference 6310-09-4(CAS DataBase Reference)
EWG's Food Scores 1
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H300-H319
Precautionary statements  P264-P270-P280-P301+P310-P305+P351+P338-P337+P313
PPE Eyeshields, Gloves, type N95 (US)
Risk Statements  20/21/22
Safety Statements  24/25-36/37
RIDADR  UN2811
WGK Germany  3
RTECS  OB1745000
HazardClass  6.1
PackingGroup  III
HS Code  29349990
Storage Class 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
Hazard Classifications Acute Tox. 2 Oral
Eye Irrit. 2
REACH Registrations Active
NFPA 704
1
0 0

2-Acetyl-5-chlorothiophene price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 247073 2-Acetyl-5-chlorothiophene 99% 6310-09-4 5g $34 2023-06-20 Buy
Sigma-Aldrich 247073 2-Acetyl-5-chlorothiophene 99% 6310-09-4 25g $115 2022-05-15 Buy
TCI Chemical A1471 2-Acetyl-5-chlorothiophene >99.0%(GC) 6310-09-4 5g $43 2026-04-30 Buy
TCI Chemical A1471 2-Acetyl-5-chlorothiophene >99.0%(GC) 6310-09-4 25g $171 2026-04-30 Buy
Activate Scientific AS33135 2-Acetyl-5-chlorothiophene 98% 5g $20 2026-06-04 Buy
Product number Packaging Price Buy
247073 5g $34 Buy
247073 25g $115 Buy
A1471 5g $43 Buy
A1471 25g $171 Buy
AS33135 5g $20 Buy

2-Acetyl-5-chlorothiophene Chemical Properties, Uses, Production

Chemical Properties

white to light yellow crystal powder

Uses

2-Acetyl-5-chlorothiophene serves as a precursor for synthesizing thiophene chalcones via Claisen-Schmidt condensation with heterocyclic or aromatic aldehydes, such as benzaldehyde, 4-chlorobenzaldehyde, and 2,4-dimethoxybenzaldehyde, in the presence of sodium hydroxide[6-8].

Synthesis

2-Chlorothiophene

96-43-5

Acetic anhydride

108-24-7

2-ACETYL-5-CHLOROTHIOPHENE

6310-09-4

Example 8: In a 100 mL four-necked flask equipped with a stirrer, a condenser, a thermometer, and a dropping funnel, 5.9 g of activated white clay (a product of Nacalai Tesque, Inc.) and 25.5 g (0.25 mol) of acetic anhydride were added sequentially. The temperature of the reaction system was maintained at 45 °C to 55 °C and 29.6 g (0.25 mol) of 2-chlorothiophene was slowly added dropwise over 1 h in this temperature range. After the dropwise addition was completed, the reaction was continued with stirring at 50 °C for 72 hours. Upon completion of the reaction, the activated white clay was removed by filtration to give a dark brown filtrate. Subsequently, unreacted 2-chlorothiophene, acetic anhydride and the by-product acetic acid were removed from the filtrate by distillation, resulting in 20.9 g (0.13 mol) of 2-acetyl-5-chlorothiophene.

References

[1] Patent: EP1695972,  2006,  A1. Location in patent: Page/Page column 7
[2] Journal of the American Chemical Society,  1947,  vol. 69,  p. 3093,3095
[3] Journal of Organic Chemistry,  1948,  vol. 13,  p. 729,732
[4] Org. Synth. Coll. Vol. IV,<1963>980,
[5] Journal of the American Chemical Society,  1947,  vol. 69,  p. 1014
[6] Al-Maqtari, H. M., Jamalis, J., & Sirat, H. M. (2015). SYNTHESIS AND CHARACTERIZATION OF HETEROCYCLIC CHALCONES CONTAINING HALOGENATED THIOPHENES. Jurnal Teknologi, 77(3). https://doi.org/10.11113/jt.v77.6005
[7] Wulan, F. F., Astuti, E., Prasetyo, N., Kumar, N., Wahyuningsih, T. D. (2025). Investigating chlorothiophene-based chalcones as anticancer agents: Synthesis, biological evaluation, and computational insight via the p53-targeted pathway. Arabian Journal of Chemistry, 18, 312024. https://doi.org/10.25259/ajc_31_2024
[8] Gita, B., Rusydi, I. D., Astuti, E., Wahyuningsih, T. D. (2026). Synthesis of novel 2-acetyl-5-chlorothiophene-based pyrazoline as “turn-off” fluorescence sensors for Hg2+. AIP Conference Proceedings, 3358, 050004. https://doi.org/10.1063/5.0296571

2-Acetyl-5-chlorothiophene Preparation Products And Raw materials

Raw materials

2-Chlorothiophene Acetyl chloride Aluminum chloride Acetic anhydride

Preparation Products

4-broMo-5-chlorothiophene-2-carboxylic acid 5-Chlorothiophene-2-carbonyl chloride Ethyl 3-(5-chlorothiophen-2-yl)-3-oxopropanoate

2-Acetyl-5-chlorothiophene Suppliers

Global Suppliers ( 220)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
New Energy Chemicals 0515-82159099 13770142076 info@njuchem.com China 251 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Supplier Advantage
J & K SCIENTIFIC LTD. 76
New Energy Chemicals 65
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64

View Latest Price from 2-Acetyl-5-chlorothiophene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-ACETYL-5-CHLOROTHIOPHENE pictures 2026-08-20 2-ACETYL-5-CHLOROTHIOPHENE
6310-09-4
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited
2-ACETYL-5-CHLOROTHIOPHENE pictures 2026-08-13 2-ACETYL-5-CHLOROTHIOPHENE
6310-09-4
 1KG 98% 2000 Shenzhen Nexcon Pharmatechs Ltd.
2-ACETYL-5-CHLOROTHIOPHENE pictures 2019-07-06 2-ACETYL-5-CHLOROTHIOPHENE
6310-09-4
 $8.00 1kg 99% 10tons Career Henan Chemical Co

2-Acetyl-5-chlorothiophene Spectrum

2-ACETYL-5-CHLOROTHIOPHENE(6310-09-4)MS2-ACETYL-5-CHLOROTHIOPHENE(6310-09-4)1HNMR2-ACETYL-5-CHLOROTHIOPHENE(6310-09-4)13CNMR2-ACETYL-5-CHLOROTHIOPHENE(6310-09-4)IR12-ACETYL-5-CHLOROTHIOPHENE(6310-09-4)IR22-ACETYL-5-CHLOROTHIOPHENE(6310-09-4)Raman

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1-(5-chloro-2-thienyl)ethan-1-one 1-(5-Chloro-thiophen-2-yl)-ethanone 5-CHLORO-2-THIENYL METHYL KETONE 5-CHLORO-2-ACETYLTHIOPHENE 2-Acetyl-5-chlorothiophene ,99% 2-Acetyl-5-chlorothiophene,5-Chloro-2-thienyl methyl ketone 2-Acetyl-5-chlorothi 2-Acetyl-5-chlorothiophene 99% 1-(5-Chlorothien-2-yl)ethan-1-one Rivaroxaban Impurity 124 2-Acetyl-5-chlorthiophen 2-Chloro-5-acetylthiophene 5-Chlor-2-acetyl thiophen 5-chlor-2-acetylthiophen 5-Chloro-2-acetyl thiophen 5-chloro-2-acetylthiophen BA 11044 ba11044 Ethanone, 1-(5-chloro-2-thienyl)- Ethanone,1-(5-chloro-2-thienyl)- Ketone, 5-chloro-2-thienyl methyl ketone,5-chloro-2-thienylmethyl 1-(5-CHLORO-2-THIENYL)ETHANONE AKOS 93296 2-Acetyl-5-chlorothiophene> 2-ACETYL-5-CHLOROTHIOPHENE ISO 9001：2015 REACH 2-Acetyl-5-chlorothiophene(Rivaroxaban Impurity) 2-Acetyl-5-chlorothiophene 6310-09-4 1610-96-7 310-09-4 6310-19-4 CH3COC4H2SCl KETONE Heterocyclic Building Blocks Halogenated Heterocycles Thiophenes Building Blocks Heterocycle-oher series Heterocycles