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N-Boc-Piperidine-4-carboxylic acid methyl ester

N-Boc-Piperidine-4-carboxylic acid methyl ester Structure
N-Boc-Piperidine-4-carboxylic acid methyl ester structure
CAS No.
124443-68-1
Chemical Name:
N-Boc-Piperidine-4-carboxylic acid methyl ester
Synonyms
1-TERT-BUTYL 4-METHYL PIPERIDINE-1,4-DICARBOXYLATE;tert-Butyl methyl piperidine-1,4-dicarboxylate;ic acid methyL;N-Boc-4-Methylpiperidine;N-boc-4-methylpiperidinate;N-Boc-Piperidine-4-carboxyL;N-Boc- Piperidine-4-carboxylate;Methyl-boc-piperidine-4-carboxylate;N-Boc-Isonipecotic acid methyl ester;N-BOC-4-METHYL PIPERIDINECARBOXYLATE
CBNumber:
CB7146350
Molecular Formula:
C12H21NO4
Molecular Weight:
243.3
MDL Number:
MFCD02183584
MOL File:
124443-68-1.mol
MSDS File:
SDS
Last updated:2026-05-28 02:53:22
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N-Boc-Piperidine-4-carboxylic acid methyl ester Properties

Melting point 33.0 to 37.0 °C
Boiling point 307.4±35.0 °C(Predicted)
Density 1.094±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
solubility soluble in Methanol
form powder to lump
pka -2.29±0.40(Predicted)
color White to Light yellow
InChI InChI=1S/C12H21NO4/c1-12(2,3)17-11(15)13-7-5-9(6-8-13)10(14)16-4/h9H,5-8H2,1-4H3
InChIKey PTZNCCIULVXFIJ-UHFFFAOYSA-N
SMILES N1(C(OC(C)(C)C)=O)CCC(C(OC)=O)CC1
CAS DataBase Reference 124443-68-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H317
Precautionary statements  P501-P261-P272-P280-P302+P352-P362+P364-P333+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
HazardClass  IRRITANT
HS Code  29333990
REACH Registrations Active

N-Boc-Piperidine-4-carboxylic acid methyl ester price More Price(67)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical M2227 Methyl 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylate >98.0%(GC) 124443-68-1 1g $20 2026-04-30 Buy
TCI Chemical M2227 Methyl 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylate >98.0%(GC) 124443-68-1 5g $46 2026-04-30 Buy
AstaTech B56857 1-BOC-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER 97% 124443-68-1 50G $34 2026-04-30 Buy
AstaTech B56857 1-BOC-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER 97% 124443-68-1 100G $59 2026-04-30 Buy
AstaTech B56857 1-BOC-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER 97% 124443-68-1 200G $76 2026-04-30 Buy
Product number Packaging Price Buy
M2227 1g $20 Buy
M2227 5g $46 Buy
B56857 50G $34 Buy
B56857 100G $59 Buy
B56857 200G $76 Buy

N-Boc-Piperidine-4-carboxylic acid methyl ester Chemical Properties, Uses, Production

Chemical Properties

White solid

Uses

Methyl (1-BOC-piperidin-4-yl)carboxylate can be used as orexin type-2 receptor agonist.

Synthesis

Methanol

67-56-1

N-BOC-piperidine-4-carboxylic acid

84358-13-4

N-Boc-Piperidine-4-carboxylic acid methyl ester

124443-68-1

General procedure for the synthesis of methyl 1-tert-butoxycarbonyl-4-piperidinecarboxylate from methanol and 1-Boc-4-piperidinecarboxylic acid: a hexane solution of trimethylmethylsilyl diazomethane (2.00 M, 52.9 mL, 106 mmol) was added slowly and dropwise at 0 °C to a 1-tert-butoxycarbonyl-piperidine-4-carboxylic acid (12.14 g, 52.95 mmol) acetonitrile ( 100 mL) suspension. Methanol (10 mL) was then added. The reaction mixture was allowed to stand at 0 °C for 30 min and then stirred at room temperature for 3 h. The reaction was carried out under reduced pressure. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was purified by column chromatography [hexane/ethyl acetate (4.5:1, v/v)] to afford 1-tert-butyl 4-methylpiperidine-1,4-dicarboxylate as a colorless oil (11.5 g, 90% yield). The structure of the product was confirmed by 1H NMR (400 MHz, d6-DMSO): δ 4.02 (dt, 2H, J = 3.5, 13.7 Hz), 3.69 (s, 3H), 2.82 (ddd, 2H, J = 3, 11.5, 14.5 Hz), 2.45 (tt, 1H, J = 3.9, 11.5 Hz), 1.90-1.84 ( m, 2H), 1.67-1.57 (m, 2H), 1.45 (s, 9H). Mass spectral analysis (ES) showed m/z 265.8 (MNa+); calculated value: 243.1 (M).

References

[1] Patent: WO2006/86609, 2006, A2. Location in patent: Page/Page column 160
[2] Tetrahedron Letters, 2004, vol. 45, # 12, p. 2663 - 2665
[3] Tetrahedron Letters, 2011, vol. 52, # 8, p. 849 - 852

N-Boc-Piperidine-4-carboxylic acid methyl ester synthesis

2971-79-1
24424-99-5
124443-68-1
Synthesis of N-Boc-Piperidine-4-carboxylic acid methyl ester from Methyl isonipecotate and Di-tert-butyl dicarbonate

N-Boc-Piperidine-4-carboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Methanol Methyl isonipecotate Di-tert-butyl dicarbonate N-BOC-piperidine-4-carboxylic acid Isonipecotic acid
(Trimethylsilyl)diazomethane petroleum ether 40 60 Acetonitrile

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Preparation Products

tert-Butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate 2-(4-Piperidyl)-2-propanol 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine 1-tert-butyl 4-methyl 4-(chloromethyl)piperidine-1,4-dicarboxylate tert-Butyl 4-(aminocarbonyl)tetrahydropyridine-1(2H)-carboxylate
1,4-Piperidinedicarboxylic acid, 4-ethyl-, 1-(1,1-dimethylethyl) 4-methyl ester 1-Boc-4-ethyl-4-formyl-piperidine N-BOC-piperidine-4-carboxylic acid

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N-Boc-Piperidine-4-carboxylic acid methyl ester Suppliers

Global Suppliers ( 280)
Supplier Tel Email Country ProdList Advantage
Anhui Dexinjia Biopharm Co., Ltd 0531-82375893 15553111391 phoebe@jndxj.com China 285 58
Beijing Jianuode Pharmaceutical Technology Co., Ltd. 010-67267894 18611880885 gianord@163.com China 33 58
YuChen Biological Medicine 0535-7295056 15692356085 sdycc1234@163.com China 133 58
Shanghai Hobor Chemical Co., Ltd 13918007836 sales@hoborchem.com China 423 60
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Supplier Advantage
Anhui Dexinjia Biopharm Co., Ltd 58
Beijing Jianuode Pharmaceutical Technology Co., Ltd. 58
YuChen Biological Medicine 58
Shanghai Hobor Chemical Co., Ltd 60
J & K SCIENTIFIC LTD. 76
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Wuhan Chemwish Technology Co., Ltd 56

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View Latest Price from N-Boc-Piperidine-4-carboxylic acid methyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Boc-Piperidine-4-carboxylic acid methyl ester pictures 2024-04-02 N-Boc-Piperidine-4-carboxylic acid methyl ester
124443-68-1
 $10.00-100.00 1kg 99% 5000 Metric Ton/Month Wuhan Xinhao Biotechnology Co., Ltd
N-Boc-Piperidine-4-carboxylic acid methyl ester pictures 2023-11-03 N-Boc-Piperidine-4-carboxylic acid methyl ester
124443-68-1
 $10.00 1kg 99% 100tons Anhui Zhongda Biotechnology Co., Ltd
N-Boc-Piperidine-4-carboxylic acid methyl ester pictures 2023-06-26 N-Boc-Piperidine-4-carboxylic acid methyl ester
124443-68-1
 $200.00 10g 99% 500kg/month Hebei Mingeng Biotechnology Co., Ltd

N-Boc-Piperidine-4-carboxylic acid methyl ester Spectrum

N-Boc-Piperidine-4-carboxylic acid methyl ester(124443-68-1)1HNMR

124443-68-1 (N-Boc-Piperidine-4-carboxylic acid methyl ester) Related Search:

Tribenuron methyl tert-Butyl acetate Isonipecotic acid tert-Butyl peroxyacetate Kresoxim-methyl
Methyl anthranilate Methyl benzoate Methyl salicylate Methylparaben Methyl formate
Methyl isonipecotate Methyl acrylate Methyl carbamate N-BOC-piperidine-4-carboxylic acid Ethyl N-Boc-piperidine-4-carboxylate
Thiophanate-methyl tert-Butanol Ethyl N-Boc-piperidine-2-carboxylate

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tert-Butyl methyl piperidine-1,4-dicarboxylate N-Boc-Isonipecotic acid methyl ester 1-(tert-butyl) 4-methyl tetrahydro-1,4(2H)-pyridinedicarboxylate N-Boc- Piperidine-4-carboxylate 1-Boc-Piperidine-4-carboxylic acid methyl ester 1,4-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 4-methyl ester Methyl-boc-piperidine-4-carboxylate Methyl 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylate 1-[(tert-butoxy)carbonyl]-4-Methylpiperidine-2-carboxylate tert-Butyl Methyl piperidine-1,5-dicarboxylate tert-Butyl Methyl piperidine-1,6-dicarboxylate tert-Butyl Methyl piperidine-1,7-dicarboxylate tert-Butyl Methyl piperidine-1,8-dicarboxylate 1-Boc-4-piperidinecarboxylic Acid Methyl Ester 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic Acid Methyl Ester 1-tert-Butyl 4-Methyl Piperidine-1,4-dicarboxylate Methyl 1-Boc-4-piperidinecarboxylate tert-Butyl Methyl piperidine-1,9-dicarboxylate N-Boc-Piperidine-4-carboxylate or 1-N-BOC-4-piperidinecarboxylic acid Methyl ester 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate, 1-(tert-Butoxycarbonyl)-4-(methoxycarbonyl)piperidine N-BOC-PIPERIDINE-4-CARBOXYLIC ACID METHYL ESTER N-BOC-4-METHYL PIPERIDINECARBOXYLATE PIPERIDINE-1,4-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 4-METHYL ESTER 1-N-BOC-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER Methyl 1-N-Boc-4-piperidinecarboxylate Methyl1-tert-butoxycarbonylpiperidine-4-carboxyla MethylN-Boc-4-piperidinecarboxylateG Methyl N-Boc-piperidine-4-carboxylate N-BOC-Piperidine-4-carboxylicacidmethyl Methyl piperidine-4-carboxylate, N-BOC protected N-BOC-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER METHYL N-BOC-4-PIPERIDINECARBOXYLATE METHYL N-BOC-PIPERIDIN-4-CARBOXYLATE 1-(tert-Butyl) 4-Methyl tetrahydro-1,4(2H)-pyridinedicarboxylate, 95+% Methyl 1-(tert-butoxycarbonyl)-4-piperidinecarboxylate 1-tert-Butyl 4-methyl 1,4-piperidinedicarboxylate O1-tert-butyl O4-methyl piperidine-1,4-dicarboxylate piperidine-1,4-dicarboxylic acid O1-tert-butyl O4-methyl ester 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic Acid Methyl Ester Methyl1-(tert-Butoxycarbonyl)-4-piperidinecarboxylate> ic acid methyL N-Boc-Piperidine-4-carboxyL N-Boc-piperidine-4-carboxylate, methyl ester 1-Boc-4-piperidinecarboxylic Acid Methyl Ester Methyl 1-Boc-4-piperidinecarboxylate Piperidine-1,4-dicarboxylic Acid 1-tert-Butyl 4-Methyl 1-O-tert-butyl 4-O-methyl piperidine-1,4-dicarboxylate 1-(1,1-Dimethylethyl) 4-methyl 1,4-piperidinedicarboxylate N-boc-4-methylpiperidinate N-Boc-Piperidine-4-Carboxylic Aacid Methyl Ester Methyl N-Boc-4-piperidinecarboxylate, 95% N-Boc-4-Methylpiperidine 1-TERT-BUTYL 4-METHYL PIPERIDINE-1,4-DICARBOXYLATE 124443-68-1 24443-68-1 124443-68-2 124443-68-6 124443-68-5 124443-68-4 124443-68-3 12443-68-1