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2,5-Difluorobenzaldehyde

2,5-Difluorobenzaldehyde Structure
2,5-Difluorobenzaldehyde structure
CAS No.
2646-90-4
Chemical Name:
2,5-Difluorobenzaldehyde
Synonyms
TIMTEC-BB SBB006570;2,5-Difluorobenzalde;Difluorobenzaldehyde;2,5-fluorobenzaldehyde;2-CHLORO-4-ETHOXYANILINE;2,5-DIFLUOROBENZALDEHYDE;2,9-Difluoroacetophenone;2,5-Diffuorobenzaldehyde;2,5-Difluoro Benzaldehydes;2,5-Difluorobenzaldehyde>
CBNumber:
CB7310342
Molecular Formula:
C7H4F2O
Molecular Weight:
142.1
MDL Number:
MFCD00010327
MOL File:
2646-90-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-12 19:08:34
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2,5-Difluorobenzaldehyde Properties

Melting point 67-69 °C
Boiling point 67-69 °C/17 mmHg (lit.)
Density 1.308 g/mL at 25 °C (lit.)
refractive index n20/D 1.498(lit.)
Flash point 138 °F
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form Liquid
Specific Gravity 1.308
color Clear colorless to yellow
Sensitive Air Sensitive
BRN 2573664
InChI InChI=1S/C7H4F2O/c8-6-1-2-7(9)5(3-6)4-10/h1-4H
InChIKey VVVOJODFBWBNBI-UHFFFAOYSA-N
SMILES C(=O)C1=CC(F)=CC=C1F
CAS DataBase Reference 2646-90-4(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Warning
Hazard statements  H226-H315-H319-H335
Precautionary statements  P210-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39-36/37
RIDADR  UN 1989 3/PG 3
WGK Germany  3
Hazard Note  Irritant
HazardClass  3.2
PackingGroup  III
HS Code  29130000
Storage Class 3 - Flammable liquids
Hazard Classifications Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3
Limited Quantities 5.0 L (1.3 gallons) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
2 0

2,5-Difluorobenzaldehyde price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 265187 2,5-Difluorobenzaldehyde 98% 2646-90-4 5g $51.9 2026-04-30 Buy
Sigma-Aldrich 265187 2,5-Difluorobenzaldehyde 98% 2646-90-4 1g $31.6 2023-06-20 Buy
TCI Chemical D2637 2,5-Difluorobenzaldehyde >96.0%(GC) 2646-90-4 5g $93 2026-04-30 Buy
TCI Chemical D2637 2,5-Difluorobenzaldehyde >96.0%(GC) 2646-90-4 25g $279 2026-04-30 Buy
Biosynth FD64014 2,5-Difluorobenzaldehyde 2646-90-4 1000g $5440 2026-06-04 Buy
Product number Packaging Price Buy
265187 5g $51.9 Buy
265187 1g $31.6 Buy
D2637 5g $93 Buy
D2637 25g $279 Buy
FD64014 1000g $5440 Buy

2,5-Difluorobenzaldehyde Chemical Properties, Uses, Production

Chemical Properties

clear light yellow liquid

Uses

2,5-Difluorobenzaldehyde was used in the synthesis of fluorinated analog by Henry condensation with nitroethane.

General Description

The emission and absorption spectra of 2,5-difluorobenzaldehyde were studied.

Synthesis

1,4-Difluorobenzene

540-36-3

N-Methylformanilide

93-61-8

2,5-Difluorobenzaldehyde

2646-90-4

Example 3 Synthesis of 2,5-difluorobenzaldehyde Procedure: to a stirred solution of 194.5 g (1.70 mol) of 1,4-difluorobenzene dissolved in 2 ml of anhydrous tetrahydrofuran was added dropwise 1.70 mol (2.2 M hexane solution) of n-butyllithium at -60°C, at a rate maintaining the temperature below -55°C. The reaction mixture was stirred below -50°C for 45 minutes, followed by continued stirring in the range of -50°C to -45°C for 1.5 hours. The solution was cooled to -30°C and 230 g of N-methylformanilide dissolved in 300 ml of tetrahydrofuran was added dropwise over 30 minutes. The mixture was stirred at -50°C for 1 hour, followed by a slow warming to -30°C over 15 minutes. The reaction mixture was poured into ice water and neutralized to pH 6-7 with 10% sulfuric acid solution, followed by three extractions with hexane. The combined organic phases were sequentially washed once each with 1N sulfuric acid solution and saturated sodium chloride solution and concentrated to give an oil. Purification by reduced pressure distillation (64°-65°C, 20 mm Hg) gave 187.5 g (77.5%) of 2,5-difluorobenzaldehyde.

References

[1] Patent: US4654336, 1987, A

2,5-Difluorobenzaldehyde Preparation Products And Raw materials

Raw materials

1,4-Difluorobenzene N-Methylformanilide n-Butyllithium Hexane Tetrahydrofuran

Preparation Products

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine 2,5-Difluorobenzyl alcohol 5-Fluoro-2-(pyrrolidin-1-yl)benzaldehyde Benzo[b]thiophene-2-carboxylic acid, 5-fluoro-, ethyl ester 5-Fluoro-benzo[b]thiophene-2-carboxylic acid methyl ester
3-Amino-3-(2,5-difluoro-phenyl)-propionic acid 1-(2,5-Difluorophenyl)ethanol

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2,5-Difluorobenzaldehyde Suppliers

Global Suppliers ( 355)
Supplier Tel Email Country ProdList Advantage
Beijing Bankchem Pharmatech Co.,Ltd. 010-80236392 17600588818 bankchem@163.com China 247 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Liaoning Tianhua Chemical Co., Ltd. 0418-6530555 2855550 China 338 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Supplier Advantage
Beijing Bankchem Pharmatech Co.,Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Liaoning Tianhua Chemical Co., Ltd. 69
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60

View Latest Price from 2,5-Difluorobenzaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,5-Difluorobenzaldehyde pictures 2026-06-13 2,5-Difluorobenzaldehyde
2646-90-4
 $1.10 1g 99.0% Min 100 Tons Shaanxi Didu New Materials Co. Ltd
2,5-Difluorobenzaldehyde pictures 2025-05-23 2,5-Difluorobenzaldehyde
2646-90-4
 $10.00 1kg 99% 20 ton Hebei Zhuanglai Chemical Trading Co Ltd
2,5-Difluorobenzaldehyde pictures 2019-07-06 2,5-Difluorobenzaldehyde
2646-90-4
 $100.00 1KG 99% Career Henan Chemical Co

2,5-Difluorobenzaldehyde Spectrum

2,5-Difluorobenzaldehyde(2646-90-4)MS2,5-Difluorobenzaldehyde(2646-90-4)1HNMR2,5-Difluorobenzaldehyde(2646-90-4)13CNMR2,5-Difluorobenzaldehyde(2646-90-4)IR1

2646-90-4 (2,5-Difluorobenzaldehyde ) Related Search:

1,3-Difluorobenzene Florfenicol 4-Fluorobenzaldehyde Transfluthrin 1,2-Difluorobenzene
Pentafluorobenzoyl chloride 2,3,4,5-Tetrafluorobenzoic acid Pentafluorobenzaldehyde 2,6-Difluorobenzaldehyde 2,3-Difluorobenzaldehyde
3,4-Difluorobenzaldehyde 2,4-Difluorobenzaldehyde Methyl pentafluorobenzoate 4-Amino-2,3,5,6-tetrafluorobenzoic acid 4-Amino-2,3,5,6-tetrafluorobenzamide
2,3,6-Trifluorobenzoic acid Pentafluorobenzoic acid 2,5-Difluorobenzoic acid

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2,5-DIFLUOROBENZALDEHYDE TIMTEC-BB SBB006570 2,5-Difluorobenzaldehyde 98% 2,5-Difluorobenzaldehyde98% 2,5-Difluoro Benzaldehydes 2,5-DIFLUOROBENZALDEHYDE 99+% 2,5-Difluorobenzalde 2,5-fluorobenzaldehyde Difluorobenzaldehyde 2-CHLORO-4-ETHOXYANILINE 2,5-Difluorobenzaldehyde> Benzaldehyde, 2,5-difluoro- 2,5-Difluorobenzaldehyde ISO 9001：2015 REACH 2,9-Difluoroacetophenone 2,5-Diffuorobenzaldehyde 2646-90-4 2664-90-4 Aldehydes Building Blocks C7 Carbonyl Compounds ALDEHYDE Organic Building Blocks Fluorine series Aromatic Aldehydes & Derivatives (substituted) Benzaldehyde Fluorobenzene Miscellaneous Adehydes, Acetals & Ketones Fluorine Compounds Fluorobenzaldehyde Series Aldehydes C7 Carbonyl Compounds Benzaldehyde series Fluorin-contained benzaldehyde series