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2,6-Difluorobenzaldehyde

2,6-Difluorobenzaldehyde Structure
2,6-Difluorobenzaldehyde structure
CAS No.
437-81-0
Chemical Name:
2,6-Difluorobenzaldehyde
Synonyms
TIMTEC-BB SBB006685;2,6-Difluorobenzalde;2-6-Difluorbenzaldehyd;2,6-fluorobenzaldehyde;2,6-DIFLUOROBENZALDEHYDE;2,6-difluorobenzaledehyde;2,6-DIFLUORLOBENZALDEHYDE;2,12-Difluoroacetophenone;2,6-Difluorobenzaldehyde98%;2,6-Difluorobenzaldehyde>
CBNumber:
CB3126149
Molecular Formula:
C7H4F2O
Molecular Weight:
142.1
MDL Number:
MFCD00010293
MOL File:
437-81-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:56:36
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2,6-Difluorobenzaldehyde Properties

Melting point 15-17 °C (lit.)
Boiling point 82-84 °C/15 mmHg (lit.)
Density 1.317 g/mL at 25 °C (lit.)
vapor pressure 40.1-900hPa at 94.5-189℃
refractive index n20/D 1.502(lit.)
Flash point 164 °F
storage temp. 2-8°C
form Liquid
Specific Gravity 1.317
color Clear light yellow to bright yellow
Sensitive Air Sensitive
BRN 1935273
InChI 1S/C7H4F2O/c8-6-2-1-3-7(9)5(6)4-10/h1-4H
InChIKey SOWRUJSGHKNOKN-UHFFFAOYSA-N
SMILES Fc1cccc(F)c1C=O
LogP 1.46 at 25℃ and pH2
Surface tension 73.1mN/m at 1g/L and 20℃
CAS DataBase Reference 437-81-0(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H335-H227-H315-H319
Precautionary statements  P210-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P403+P235-P501-P210e-P261-P280a-P305+P351+P338-P405-P501a
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37/39-37/39-36/37
WGK Germany  2
F  10-23
HazardClass  IRRITANT
HS Code  29130000
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Aquatic Chronic 3
Eye Dam. 1
Skin Corr. 1C
REACH Registrations Inactive
NFPA 704
2
2 0

2,6-Difluorobenzaldehyde price More Price(70)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 265152 2,6-Difluorobenzaldehyde 98% 437-81-0 5g $29.3 2026-04-30 Buy
Sigma-Aldrich 265152 2,6-Difluorobenzaldehyde 98% 437-81-0 25g $140 2026-04-30 Buy
TCI Chemical D2452 2,6-Difluorobenzaldehyde >98.0%(GC) 437-81-0 5g $42 2026-04-30 Buy
TCI Chemical D2452 2,6-Difluorobenzaldehyde >98.0%(GC) 437-81-0 25g $143 2026-04-30 Buy
Usbiological 273188 2.6-Difluorobenzaldehyde ≥98% 437-81-0 100g $295 2026-06-03 Buy
Product number Packaging Price Buy
265152 5g $29.3 Buy
265152 25g $140 Buy
D2452 5g $42 Buy
D2452 25g $143 Buy
273188 100g $295 Buy

2,6-Difluorobenzaldehyde Chemical Properties,Uses,Production

Chemical Properties

clear light yellow to bright yellow liquid

Uses

2,6-Difluorobenzaldehyde can be used as a reactant to synthesize:

  • 5-Cyano-6-(2,6-difluorophenyl)-5,6-dihydro-2-thiouracil via one-pot cyclocondensation reaction with ethyl cyanoacetate and thiourea.
  • 1-(2,6-Difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazole by reacting with 1,2-phenylenediamine in the presence of a catalytic amount of p-toluenesulfonic acid.
  • (3E)-4-(2,6-Difluorophenyl)-3-buten-2-one by Wittig olefination reaction with acetylmethylidenetriphenyl phosphorane.
  • Methyl 4-fluorobenzo[b]thiophene-2-carboxylate by treating with methyl thioglycolate in the presence of K2CO3.

Synthesis

2,6-Dichlorobenzaldehyde

83-38-5

2,6-Difluorobenzaldehyde

437-81-0

The general procedure for the synthesis of 2,6-dichlorobenzaldehyde from 2,6-dichlorobenzaldehyde was as follows: first, 34.8 g (0.6 mol) of potassium fluoride (KF) was dissolved in 250 mL of cyclobutanesulfone under nitrogen protection and stirred at 100 °C for 2 h. The water was removed by azeotropic distillation. Subsequently, 20 g (0.11 mol) of 2,6-dichlorobenzaldehyde and 2.8 g (6.68 mmol) of tetraphenylphosphonium bromide were added to this anhydrous mixture and the reaction mixture was heated to 180 °C and kept overnight. Upon completion of the reaction, the solid product was washed with ethyl acetate and the solvent was removed by aqueous pressure evaporation. Finally, the target product 2,6-difluorobenzaldehyde was purified by vacuum evaporation (24 mbar, 85-86 °C) in 77% yield.

References

[1] Patent: WO2016/102207, 2016, A1. Location in patent: Page/Page column 32
[2] Journal of Fluorine Chemistry, 2004, vol. 125, # 6, p. 1031 - 1038
[3] Chemistry Letters, 1988, # 9, p. 1355 - 1358
[4] Angewandte Chemie - International Edition, 2006, vol. 45, # 17, p. 2720 - 2725
[5] Patent: US6103659, 2000, A

2,6-Difluorobenzaldehyde Preparation Products And Raw materials

Raw materials

2-Chloro-6-fluorobenzaldehyde 2,6-Difluorobenzonitrile 2,6-Dichlorobenzaldehyde 2,6-Difluorotoluene 1,3-Difluorobenzene
Methanol N-Methylformanilide Ethyl formate N,N-Dimethylformamide Tetraphenylphosphonium bromide

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Preparation Products

2,6-Difluorobenzyl bromide 2,6-Difluorobenzoic acid Benzo[b]thiophene, 4-fluoro- (9CI) 4-Fluoro (1H)indazole 2,6-Difluorophenol

2,6-Difluorobenzaldehyde Suppliers

Global( 438)Suppliers
Supplier Tel Email Country ProdList Advantage
Zaozhuang Benefit Chemical Co., Ltd. 0531-69958783 15508681609 1948129184@qq.com China 208 60
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Supplier Advantage
Zaozhuang Benefit Chemical Co., Ltd. 60
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
future industrial shanghai co., ltd 65
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60

View Lastest Price from 2,6-Difluorobenzaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,6-Difluorobenzaldehyde pictures 2026-09-02 2,6-Difluorobenzaldehyde
437-81-0
 $5.00 1KG 99% Henan Fengda Chemical Co., Ltd
2,6-Difluorobenzaldehyde pictures 2026-06-30 2,6-Difluorobenzaldehyde
437-81-0
 1KG 99.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2, 6-Difluoro-Benzaldehyde pictures 2026-05-28 2, 6-Difluoro-Benzaldehyde
437-81-0
 $9.00 1KG 99% 10 ton Hebei Chuanghai Biotechnology Co,.LTD

2,6-Difluorobenzaldehyde Spectrum

2,6-Difluorobenzaldehyde(437-81-0)1HNMR2,6-Difluorobenzaldehyde(437-81-0)IR2,6-Difluorobenzaldehyde(437-81-0)Raman

437-81-0(2,6-Difluorobenzaldehyde)Related Search:

4-Fluorobenzaldehyde Transfluthrin 1,2-Difluorobenzene 1,3-Difluorobenzene Florfenicol
1-(2,6-Difluorophenyl)ethan-1-one 2,3,5,6-Tetrafluorobenzoic acid Tetrafluoroterephthalic acid 2,6-Difluorobenzoyl chloride 3,4-Difluorobenzaldehyde
2,3-Difluorobenzaldehyde 2,4-Difluorobenzaldehyde 2,3,4,5,6-Pentafluorobenzamide 4-Amino-2,3,5,6-tetrafluorobenzoic acid 2,6-Difluorobenzophenone
2,3,6-Trifluorobenzoic acid 2,3,4,5,6-Pentafluorobenzophenone 2,6-Difluorobenzoic acid

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TIMTEC-BB SBB006685 2,6-Difluorobenzaldehyde,97% 2,6-DIFLUOROBENZALDEHYDE 3,4,5-triflurobenzenenitrile 2,6-Difluorobenzaldehyde 98% 2,6-Difluorobenzaldehyde98% 2,6-DIFLUORLOBENZALDEHYDE 2-6-Difluorbenzaldehyd 2,6-Difluorobenzalde 2,6-difluorobenzaledehyde 2,6-fluorobenzaldehyde 2,6-Difluorobenzaldehyde, 98% 5GR 2,6-Difluorobenzaldehyde Vetec(TM) reagent grade, 98% 2,6-Difluorobenzaldehyde> Benzaldehyde, 2,6-difluoro- 2,6-Difluorobenzaldehyde ISO 9001：2015 REACH 2,12-Difluoroacetophenone 437-81-0 Organic Building Blocks Aldehydes Building Blocks Carbonyl Compounds C7 Fluorine series Building Blocks Chemical Synthesis Fluorinated Building Blocks Organic Building Blocks Organic Fluorinated Building Blocks Other Fluorinated Organic Building Blocks Aromatic Aldehydes & Derivatives (substituted) Benzaldehyde API intermediates Fluorobenzene Carbonyl Compounds Miscellaneous Aldehydes C7 Carbonyl Compounds Aryl Fluorinated Building Blocks