Leucettine L41
- CAS No.
- 1112978-84-3
- Chemical Name:
- Leucettine L41
- Synonyms
- Leucettine L41;Leucettine L41,Leucettine L-41;(Z)-4-(Benzo[d][1,3]dioxol-5-ylmethylene)-2-(phenylamino)-1H-imidazol-5(4H)-one;4H-Imidazol-4-one, 5-(1,3-benzodioxol-5-ylmethylene)-3,5-dihydro-2-(phenylamino)-, (5Z)-
- CBNumber:
- CB73152956
- Molecular Formula:
- C17H13N3O3
- Molecular Weight:
- 307.3
- MDL Number:
- MOL File:
- 1112978-84-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >260 °C(Solvent: Ethanol) |
|---|---|
| Boiling point | 475.009±55.00 °C(Press: 760.00 Torr)(predicted) |
| Density | 1.419±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: soluble; Ethanol: soluble |
| form | A solid |
| pka | -0.429±0.20(predicted) |
| color | Light yellow to yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| NFPA 704 |
|
Leucettine L41 price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29225 | Leucettine L41 ≥98% | 1112978-84-3 | 1mg | $69 | 2026-04-30 | Buy |
| Cayman Chemical | 29225 | Leucettine L41 ≥98% | 1112978-84-3 | 5mg | $263 | 2026-04-30 | Buy |
| Cayman Chemical | 29225 | Leucettine L41 ≥98% | 1112978-84-3 | 10mg | $493 | 2026-04-30 | Buy |
| Usbiological | 207259 | Leucettine L41 ((5Z)-5-(1,3-Benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4one) ~98%(NMR) | 1112978-84-3 | 1mg | $295 | 2026-06-03 | Buy |
| Usbiological | 207259 | Leucettine L41 ((5Z)-5-(1,3-Benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4one) ~98%(NMR) | 1112978-84-3 | 5mg | $505 | 2026-06-03 | Buy |
Leucettine L41 Chemical Properties, Uses, Production
Description
Leucettine L41 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), DYRK2, CDC-like kinase 1 (CLK1), and CLK3 (IC50s = 0.04, 0.035, 0.015, and 4.5 μM, respectively).1 It also inhibits GSK3α/β and Pim1 with IC50 values of 0.41 and 4.1 μM, respectively. It inhibits phosphorylation of the serine/arginine (SR) protein 9G8 by DYRK2, DYRK3, CLK1, CLK2, and CLK4 and inhibits TNF-α-induced SRp75 and SRp55 phosphorylation in human microvascular endothelial cells when used at concentrations ranging from 0.1 to 10 μM. Leucettine L41 modulates alternative pre-RNA splicing of a synthetic CLK1 minigene in a reporter model. It prevents lipid peroxidation and the accumulation of reactive oxygen species (ROS) induced by amyloid-β 25-35 in the hippocampus in a mouse model of Alzheimer’s disease-like toxicity.2 Leucettine L41 (0.4, 1.2, and 4 μg, i.c.v.) also prevents memory deficits induced by amyloid-β 25-35 in the same model.
Uses
Leucettine L41 is a potent inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), DYRK2, CDC-like kinase 1 (CLK1), and CLK3 (IC50s = 0.04, 0.035, 0.015, and 4.5 μM, respectively)[1]. Leucettine L41 prevents lipid peroxidation and the accumulation of reactive oxygen species (ROS) induced by Aβ25-35 in the hippocampus in a mouse model of Alzheimer’s disease-like toxicity. Leucettine L41 also prevents memory deficits induced by Aβ25-35 in the same model[2].
References
1. Debdab, M., Carreaux, F., Renault, S., et al. Leucettines, a class of potent inhibitors of cdc2-
2. Naert, G., Ferré, V., Meunier, J., et al. Leucettine L41, a DYRK1A-
Leucettine L41 Preparation Products And Raw materials
Raw materials
Preparation Products
Leucettine L41 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 959 | 58 |
| Suzhou Chenrui Biotechnology Co. LTD | 17625585511 | 1580084073@qq.com | China | 992 | 58 |
View Latest Price from Leucettine L41 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Leucettine L41
1112978-84-3
|
$78.00-355.00 | 99.08% | 10g | TargetMol Chemicals Inc. |
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- Leucettine L41
1112978-84-3
- $78.00-355.00
- 99.08%
- TargetMol Chemicals Inc.
