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Tubulysin B

Tubulysin B Structure
Tubulysin B structure
CAS No.
205304-87-6
Chemical Name:
Tubulysin B
Synonyms
Tubulysin B;(2S,4R)-4-({2-[(1R,3R)-1-(acetyloxy)-3-[(2S,3S)-N-[(butanoyloxy)methyl]-3-methyl-2-{[(2R)-1-methylpiperidin-2-yl]formamido}pentanamido]-4-methylpentyl]-1,3-thiazol-4-yl}formamido)-5-(4-hydroxyphenyl)-2-methylpentanoic acid;Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)-
CBNumber:
CB73339922
Molecular Formula:
C42H63N5O10S
Molecular Weight:
830.05
MDL Number:
MFCD29477701
MOL File:
205304-87-6.mol
MSDS File:
SDS
Last updated:2026-07-13 19:59:05
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Tubulysin B Properties

Boiling point 978.0±65.0 °C(Predicted)
Density 1.204±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
pka 4.52±0.23(Predicted)
color White to off-white
InChIKey HWCIETDQUHYHGQ-OSGLCLOFNA-N
FDA UNII 44D2D2M50T

Tubulysin B price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FIA30487 Tubulysin B 205304-87-6 1mg $4997.3 2026-06-04 Buy
ChemScene CS-0016644 Tubulysin B 99.88% 205304-87-6 1mg $758 2026-06-04 Buy
ChemScene CS-0016644 Tubulysin B 99.88% 205304-87-6 5mg $1896 2026-06-04 Buy
ChemScene CS-0016644 Tubulysin B 99.88% 205304-87-6 10mg $3033 2026-06-04 Buy
Arctom HY-N1243 Tubulysin B 99.88% 205304-87-6 1mg $665 2026-05-26 Buy
Product number Packaging Price Buy
FIA30487 1mg $4997.3 Buy
CS-0016644 1mg $758 Buy
CS-0016644 5mg $1896 Buy
CS-0016644 10mg $3033 Buy
HY-N1243 1mg $665 Buy

Tubulysin B Chemical Properties, Uses, Production

Description

Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agent isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC50 values in the picomolar range against many cancer cell lines, including those with multidrug-resistant properties. It is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis.

Uses

Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties[1].Tubulysin B is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2].

Definition

ChEBI: Tubulysin B is a butyrate ester.

in vitro

Tubulysin B has IC50s of 0.6 and 0.9 nM against KB and A549 tumors cell lines, respectively.

References

[1] Leamon CP, et al. Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate. Bioconjug Chem. 2019 Jun 19;30(6):1805-1813. DOI:10.1021/acs.bioconjchem.9b00335
[2] Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81. DOI:10.1016/j.bmcl.2011.09.041

Tubulysin B Preparation Products And Raw materials

Raw materials

Preparation Products

Tubulysin B Suppliers

Global Suppliers ( 20)
Supplier Tel Email Country ProdList Advantage
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9699 58
Angel Pharmatech, Ltd. 17317130613 3358272972@qq.com China 3307 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9718 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Tianjin Shangde Medicine Edge Technology Co., Ltd 13370460931 sales@accendatech.com China 11 58
Hangzhou FuRun Pharmaceutical Technology Co., Ltd 15658004993 1900830611@qq.com China 980 58
NewCan Biotech Limited +86-0571-86912261 +86-15658003402 sales@newcanbio.com China 1980 58
Hunan ravel Biotechnology Co.,Ltd 18086085632 435918333@qq.com China 1927 58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. +86-027-59232304 15387063101 1276242629@qq.com China 9977 58
Supplier Advantage
Shanghai Chaolan Chemical Technology Center 58
Angel Pharmatech, Ltd. 58
Fan De(Beijing) Biotechnology Co., Ltd. 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
Tianjin Shangde Medicine Edge Technology Co., Ltd 58
Hangzhou FuRun Pharmaceutical Technology Co., Ltd 58
NewCan Biotech Limited 58
Hunan ravel Biotechnology Co.,Ltd 58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. 58

View Latest Price from Tubulysin B manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tubulysin B pictures 2026-07-13 Tubulysin B
205304-87-6
 1g 98 1000g Shaanxi Dideu New Materials Co. Ltd
  • Tubulysin B pictures
  • Tubulysin B
    205304-87-6
  • $0.00
  • 98
  • Shaanxi Dideu New Materials Co. Ltd

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Tubulysin B Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)- (2S,4R)-4-({2-[(1R,3R)-1-(acetyloxy)-3-[(2S,3S)-N-[(butanoyloxy)methyl]-3-methyl-2-{[(2R)-1-methylpiperidin-2-yl]formamido}pentanamido]-4-methylpentyl]-1,3-thiazol-4-yl}formamido)-5-(4-hydroxyphenyl)-2-methylpentanoic acid 205304-87-6 C42H63N5O10S