N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
![N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide Structure](CAS/20180601/GIF/1362151-42-5.gif)
- CAS No.
- 1362151-42-5
- Chemical Name:
- N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
- Synonyms
- GNE-618;GNE618,GNE 618;N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide;1H-Pyrazolo[3,4-b]pyridine-5-carboxamide, N-[[4-[[3-(trifluoromethyl)phenyl]sulfonyl]phenyl]methyl]-
- CBNumber:
- CB73373023
- Molecular Formula:
- C21H15F3N4O3S
- Molecular Weight:
- 460.4290096
- MDL Number:
- MFCD28411709
- MOL File:
- 1362151-42-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 37223 | GNE-618 ≥98% | 1362151-42-5 | 1mg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 37223 | GNE-618 ≥98% | 1362151-42-5 | 5mg | $184 | 2026-04-30 | Buy |
| Cayman Chemical | 37223 | GNE-618 ≥98% | 1362151-42-5 | 10mg | $306 | 2026-04-30 | Buy |
| ChemScene | CS-0012107 | GNE-618 99.89% | 1362151-42-5 | 5mg | $195 | 2026-06-04 | Buy |
| ChemScene | CS-0012107 | GNE-618 99.89% | 1362151-42-5 | 10mg | $292 | 2026-06-04 | Buy |
N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide Chemical Properties,Uses,Production
Description
GNE-618 is an inhibitor of nicotinamide phosphoribosyl transferase (NAMPT).
Uses
GNE-618 is a potent, orally active nicotinamide phosphoribosyl transferase (NAMPT) inhibitor with an IC50 of 6 nM. GNE-618 depletes NAD levels and induces tumor cell death. Anti-tumor activity[1].
in vivo
GNE-618 (100 mg/kg; p.o.; twice daily for 5 days) significantly inhibits tumor growth by 88% and has minimal effects on body weight in STO#81 patient-derived gastric model[1].
References
[1] Xiao Y, et al. Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway rendersthem sensitive to NAMPT inhibition with GNE-618. Neoplasia. 2013 Oct;15(10):1151-60. DOI:10.1593/neo.131304
[2] XIAOZHANG ZHENG . Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23 20: Pages 5488-5497. DOI: 10.1016/j.bmcl.2013.08.074
N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 955 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai Lingfei Pharmaceutical Technology Co., Ltd | 15618928656 | 771909552@qq.com | China | 1265 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50089 | 58 |
