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SCOULERIN

SCOULERIN structure

CAS No.: 6451-73-6

Chemical Name:: SCOULERIN

Synonyms: SCOULERIN;Scoreline;l-skoulerine;l-scoulerine;SCOULERIN(SH);Alkaloid HF-1;SCOULERIN(RG);(-)-Scoulerin;(-)-scoulerine;2,9-DIOXY-3,10-DIMETHOXYBERBINE

CBNumber:: CB7382903

Molecular Formula:: C19H21NO4

Molecular Weight:: 327.37

MDL Number:: MFCD00221721

MOL File:: 6451-73-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

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SCOULERIN Properties

Melting point	192°C
Boiling point	503.3±50.0 °C(Predicted)
Density	1.37±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	A crystalline solid
pka	9.88±0.20(Predicted)
color	Off-white to pink
InChI	InChI=1S/C19H21NO4/c1-23-17-4-3-11-7-15-13-9-16(21)18(24-2)8-12(13)5-6-20(15)10-14(11)19(17)22/h3-4,8-9,15,21-22H,5-7,10H2,1-2H3/t15-/m0/s1
InChIKey	KNWVMRVOBAFFMH-HNNXBMFYSA-N
SMILES	C12=CC(O)=C(OC)C=C1CCN1[C@@]2([H])CC2=CC=C(OC)C(O)=C2C1

SCOULERIN price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	35140	Scoulerine ≥95%	6451-73-6	1mg	$54	2026-04-30	Buy
Cayman Chemical	35140	Scoulerine ≥95%	6451-73-6	5mg	$209	2026-04-30	Buy
Cayman Chemical	35140	Scoulerine ≥95%	6451-73-6	10mg	$367	2026-04-30	Buy
Biosynth	S-2120	(-)-Scoulerin	6451-73-6	5g	$364.15	2026-06-05	Buy
Biosynth	S-2120	(-)-Scoulerin	6451-73-6	10g	$606.9	2026-06-05	Buy

Product number	Packaging	Price	Buy
35140	1mg	$54	Buy
35140	5mg	$209	Buy
35140	10mg	$367	Buy
S-2120	5g	$364.15	Buy
S-2120	10g	$606.9	Buy

SCOULERIN Chemical Properties, Uses, Production

Description

This form of the alkaloid is more widespread than the d-form, occurring in Corydalis caseana, C. micrantha, C. montana, C. scouleri, C. sibirica and Papaver somniferum. It has [α]²⁶_D - 318° (c 0.41, MeOH) or - 289° (c 0.62, MeOH). It forms pale grey needles when crystallized from MeOH. The hydrochloride has m.p. 268-9°C; the picrate, m.p. 206°C (dec.) and the diethyl ether, m.p. 155°C. The oxidation products are the same as for the preceding base.

Chemical Properties

Off-White to Pale Pink Solid

Uses

The S-(+)-enantiomer of Scoulerine, an alkaloid found in the opium poppy.

Uses

(S)-Scoulerine is an alkaloid found in the opium poppy. (S)-Scoulerine acts as an antagonist at the α2-adrenoceptor, α1D-adrenoceptor and 5-HT receptor.

Definition

ChEBI: A berberine alkaloid isolated from Corydalis saxicola.

IC 50

BACE1

References

Manske., Can. J. Res., 14B, 347, 354 (1936)
Manske., ibid, 17B, 57 (1939)
Manske., ibid, 18B, 414 (1940)
Manske., ibid, 20B, 49 (1942)
Brochmann-Hanssen, Nielsen., Tetrahedron Lett., 2261 (1966)
Synthesis:
Kametani., Japanese Patent, 70, 37,976, 10 December 1970

SCOULERIN Preparation Products And Raw materials

Raw materials

Preparation Products

SCOULERIN Suppliers

Global Suppliers ( 117)

Supplier	Tel	Email	Country	ProdList	Advantage
BioBioPha Co., Ltd.	0871-65217109	y.liu@mail.biobiopha.com	China	5641	65
Shanghai Taopu Industrial Co., LTD	15900573766 18018507602	3165608826@qq.com	China	4403	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Chengdu Biopurify Phytochemicals Ltd.	+86-028-82633397 18982077548	cwb1@biopurify.cn	China	2376	60
Shanghai Tauto Biotech Co., Ltd.	021-51320588	tauto@tautobiotech.com	China	3984	66
Wuxi Zhongkun Biochemical Technology Co., Ltd.	0510-85629785 18013409632;	sales@reading-chemicals.com	China	15165	58
Finetech Industry Limited	027-87465837 19945049750	sales@finetechnology-ind.com	China	9331	58
Shanghai Yongye Biotechnology Co., Ltd.	86-021-61559134 15921386130	3423497944@qq.com	China	8135	55
Hunan Cangood Medical Technology Ltd.	400-026-9899		China	71	50

Supplier	Advantage
BioBioPha Co., Ltd.	65
Shanghai Taopu Industrial Co., LTD	58
J & K SCIENTIFIC LTD.	76
Chemsky（shanghai）International Co.,Ltd.	50
Chengdu Biopurify Phytochemicals Ltd.	60
Shanghai Tauto Biotech Co., Ltd.	66
Wuxi Zhongkun Biochemical Technology Co., Ltd.	58
Finetech Industry Limited	58
Shanghai Yongye Biotechnology Co., Ltd.	55
Hunan Cangood Medical Technology Ltd.	50

View Latest Price from SCOULERIN manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	Scoulerine 6451-73-6	$44.00-289.00		99.64%	10g	TargetMol Chemicals Inc.
	2020-01-05	SCOULERIN 6451-73-6	$1.00	1KG	95-99%	1ton	Career Henan Chemical Co

Scoulerine
6451-73-6
$44.00-289.00
99.64%
TargetMol Chemicals Inc.

SCOULERIN
6451-73-6
$1.00
95-99%
Career Henan Chemical Co

SCOULERIN Spectrum

SCOULERIN(6451-73-6)¹HNMR

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SCOULERIN SCOULERIN(SH) (13aS)-5,8,13,13a-tTtrahydro-3,10-diMethoxy-6H-dibenzo[a,g]quinolizine-2,9-diol (S)-5,8,13,13a-Tetrahydro-3,10-diMethoxy-6H-Dibenzo[a,g]quinolizine-2,9-diol Alkaloid HF 1, froM HunneMannia fuMariaefolia (-)-scoulerine 3,10-dimethoxy-13a-alpha-berbine-2,9-diol 3,10-dimethoxy-13a-alpha-berbine-9-diol g)quinolizine-2,9-diol,5,8,13,13a-tetrahydro-3,10-dimethoxy-6h-dibenzo(( l-scoulerine l-skoulerine 2,9-DIOXY-3,10-DIMETHOXYBERBINE (13aR)-5,8,13,13a-Tetrahydro-3,10-dimethoxy-6H-dibenzo[a,g]quinolizine-2,9-diol [13aR,(+)]-5,8,13,13aβ-Tetrahydro-3,10-dimethoxy-6H-dibenzo[a,g]quinolizine-2,9-diol 3,10-Dimethoxy-13aα-berbine-2,9-diol Alkaloid HF-1 SCOULERIN(RG) 6H-Dibenzo[a,g]quinolizine-2,9-diol, 5,8,13,13a-tetrahydro-3,10-dimethoxy-, (13aS)- Scoreline (13aS)-3,10-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,9-diol (S)-3,10-Dimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline-2,9-diol proliferation,Inhibitor,cancer,Beta-secretase,Scoulerine,Apoptosis,inhibit,microtubule,cycle,β-Secretase,Microtubule/Tubulin,leukemic,BACE,cells,division,mitotic,Discretamine (-)-Scoulerin 6451-73-6 Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Alkaloids