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2,4-Dihydroxy-3-nitropyridine

2,4-Dihydroxy-3-nitropyridine structure

CAS No.: 89282-12-2

Chemical Name:: 2,4-Dihydroxy-3-nitropyridine

Synonyms: 3-NITRO-2,4-PYRIDINEDIOL;Dihydroxy-3-nitropyridine;4-Dihydroxy-3-nitropyridine;2,4-Dihyroxy-3-nitropyridine;2,4-Hydroxy-3-nitropyridine.;4-Hydroxy-3-nitro-2-pyridone;2,4-Diydroxy-3-nitropyridine;2,4-DIHYDROXY-3-NITROPYRIDINE;4,6-DIHYDROXY-5-NITRO PYRIDINE;2,4-Dihydroxy-3-nitropyridine-1

CBNumber:: CB7405853

Molecular Formula:: C5H4N2O4

Molecular Weight:: 156.1

MDL Number:: MFCD01075671

MOL File:: 89282-12-2.mol

MSDS File:: SDS

Last updated:2026-05-28 03:04:21

Product description	Number	Pack Size	Price
2,4-DIHYDROXY-3-NITROPYRIDINE Aldrich^CPR	R436798	1 unit	$32.7
2,4-DIHYDROXY-3-NITROPYRIDINE AldrichCPR	R436798	1G	$29.8
2,4-Dihydroxy-3-nitropyridine >98.0%(GC)	D4002	5g	$36
2,4-Dihydroxy-3-nitropyridine >98.0%(GC)	D4002	25g	$106
2,4-Dihydroxy-3-nitropyridine Asreported	270653	50g	$366
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2,4-Dihydroxy-3-nitropyridine Properties

Melting point	265°C (dec.)
Boiling point	305.6±42.0 °C(Predicted)
Density	1.65±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
form	powder to crystal
pka	4.50±1.00(Predicted)
color	Light yellow to Yellow to Green
BRN	149558
InChI	InChI=1S/C5H4N2O4/c8-3-1-2-6-5(9)4(3)7(10)11/h1-2H,(H2,6,8,9)
InChIKey	BKYGVGWYPFVKTK-UHFFFAOYSA-N
SMILES	C1(=O)NC=CC(O)=C1[N+]([O-])=O
CAS DataBase Reference	89282-12-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37/39-37

RIDADR

3335

HS Code

29333990

NFPA 704

	1
2		0

2,4-Dihydroxy-3-nitropyridine price More Price(75)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	R436798	2,4-DIHYDROXY-3-NITROPYRIDINE Aldrich^CPR	89282-12-2	1 unit	$32.7	2026-04-30	Buy
Sigma-Aldrich	R436798	2,4-DIHYDROXY-3-NITROPYRIDINE AldrichCPR	89282-12-2	1G	$29.8	2024-03-01	Buy
TCI Chemical	D4002	2,4-Dihydroxy-3-nitropyridine >98.0%(GC)	89282-12-2	5g	$36	2026-04-30	Buy
TCI Chemical	D4002	2,4-Dihydroxy-3-nitropyridine >98.0%(GC)	89282-12-2	25g	$106	2026-04-30	Buy
Usbiological	270653	2,4-Dihydroxy-3-nitropyridine Asreported	89282-12-2	50g	$366	2026-06-03	Buy

Product number	Packaging	Price	Buy
R436798	1 unit	$32.7	Buy
R436798	1G	$29.8	Buy
D4002	5g	$36	Buy
D4002	25g	$106	Buy
270653	50g	$366	Buy

2,4-Dihydroxy-3-nitropyridine Chemical Properties,Uses,Production

Uses

2,4-Dihydroxy-3-nitropyridine can be used as a material additive, pharmaceutical chemical, and organic synthesis intermediate. During synthetic transformation, the hydroxyl groups in the structure can be easily converted into halogen atoms due to the influence of the pyridine ring and nitro group. It should be noted that by changing the reaction conditions, one of the two hydroxyl groups can be selectively halogenated, or both can be converted simultaneously. Furthermore, under acidic conditions, a bromine atom can be introduced at the 5-position of the pyridine using liquid bromine.

Chemical Properties

Yellow powder

Reactions

2,4-Dihydroxy-3-nitropyridine could be quickly transformed into 5-bromo-2,4-dihydroxy-3-nitropyridine by the action of a solution of bromine. 3.5 g of 2,4-Dihydroxy-3-nitropyridine were heated with a mixture of 1.15 ml of bromine and 30 ml of acetic acid at 70℃ for 15 minutes. When the reaction mixture was cooled with ice, 3.7 g of 5-bromo-2,4-dihydroxy-3-nitropyridine separated out[1]. Yield: 70 %

Synthesis

626-03-9

89282-12-2

Step 59a. Synthesis of 2,4-dihydroxy-3-nitropyridine (compound 0108): fuming nitric acid (90 mL) was slowly added to a stirring solution of 2,4-dihydroxypyridine (0601) (100 g, 0.9 mol) dissolved in ethyl acetate (300 mL) at 0 °C. After 45 minutes of reaction, the reaction solution was carefully poured into crushed ice and the mixture was cooled in a refrigerator. The resulting precipitate was collected by filtration, washed with cold water and dried to give 4-hydroxy-3-nitropyridin-2(1H)-one (0108) (135 g, 96% yield) as a light yellow solid.LCMS: 157 [M + 1]+; 1H NMR (DMSO-d6) δ 6.05 (d, 1H, J = 7.2 Hz), 7.47 (d, 1H, J = 7.2 Hz), 11.91 (s, 1H), 12.47 (s, 1H).

References

[1] Kolder, C. R. , and H. J. D. Hertog . Migration of halogen atoms in halogeno-derivatives of 2,4-dihydroxypyridine (II). Recueil des Travaux Chimiques des Pays-Bas 72.10(2010):853-858.

2,4-Dihydroxy-3-nitropyridine Preparation Products And Raw materials

Raw materials

NITRIC ACID 2,4-Dihydroxypyridine Nitric acid Sulfuric acid 4,6-Dihydroxynicotinic acid

Preparation Products

2,4-Dichloro-3-nitropyridine 2,4-DICHLORO-3-AMINO-6-BROMOPYRIDINE 2,4-DICHLORO-3-AMINOPYRIDINE 4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE 2(1H)-Pyridinone,3-amino-4-hydroxy-(9CI)

4-Chloro-2-hydroxy-3-nitropyridine

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2,4-Dihydroxy-3-nitropyridine Suppliers

Global( 294)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21533	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2949	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759	marketing1@neostarunited.com	China	8827	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17339	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1059@dideu.com	China	29096	58
Finetech Industry Limited	+86-27-8746-5837 +86-18627785180	info@finetechnology-ind.com	China	9539	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52693	58
CD Chemical Group Limited	+86-13651442114	info@codchem.com	China	17253	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Jinan Finer Chemical Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
SIMAGCHEM CORP	58
Dideu Industries Group Limited	58
Finetech Industry Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
CD Chemical Group Limited	58

View Lastest Price from 2,4-Dihydroxy-3-nitropyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	2,4-Dihydroxy-3-nitropyridine 89282-12-2	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2025-04-04	2,4-Dihydroxy-3-nitropyridine 89282-12-2		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2019-07-06	2,4-Dihydroxy-3-nitropyridine 89282-12-2	$1.00	1kg	99%		Career Henan Chemical Co

2,4-Dihydroxy-3-nitropyridine
89282-12-2
$1.10
99.00%
Dideu Industries Group Limited

2,4-Dihydroxy-3-nitropyridine
89282-12-2
98%
Henan Aochuang Chemical Co.,Ltd.

2,4-Dihydroxy-3-nitropyridine
89282-12-2
$1.00
99%
Career Henan Chemical Co

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4-Hydroxy-3-nitropyridine 2,4-DICHLORO-5-NITROPYRIDINE NITROGEN DIOXIDE

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2,4-DIHYDROXY-3-NITROPYRIDINE 4,6-DIHYDROXY-5-NITRO PYRIDINE 3-NITRO-2,4-PYRIDINEDIOL 4-Hydroxy-3-nitro-2-pyridone 2,4-Hydroxy-3-nitropyridine. 2(1H)-Pyridinone, 4-hydroxy-3-nitro- 2,4-Dihydroxy-3-nitropyridine ,99% 4-Dihydroxy-3-nitropyridine 3-Nitro-2,4-pyridinediol 4-Hydroxy-3-nitro-2-pyridone 4-Hydroxy-3-nitro-2(1H)-pyridinone 2,4-Dihyroxy-3-nitropyridine 2-hydroxy-3-nitro-1H-pyridin-4-one Dihydroxy-3-nitropyridine 4-hydroxy-3-nitro-2(1H)-pyridone 2,4-Diydroxy-3-nitropyridine 2,4-Dihydroxy-3-nitropyridine-1 2,4-Dihydroxy-3-nitropyridine> 4-Hydroxy-3-nitro-2(1H)-pyridinone 2,4-Dihydroxy-3-nitropyridine ISO 9001：2015 REACH 4-Hydroxy-3-nitropyridin-2(1H)-one 4-hydroxy-3-nitro-1H-pyridin-2-one 89282-12-2 Pyridine Series Heterocycle-Pyridine series Pyridine Heterocycles